CAS 92921-24-9

Sulfo-SMCC sodio

Descrizione:

Sulfo-SMCC sodio, con il numero CAS 92921-24-9, è un composto chimico comunemente usato come agente di reticolazione nella bioconjugazione e nella chimica delle proteine. È un reagente solubile in acqua che facilita la formazione di legami covalenti stabili tra proteine, peptidi e altre biomolecole, rendendolo prezioso in varie applicazioni come lo sviluppo di farmaci, la diagnostica e la creazione di coniugati anticorpo-farmaco. Il composto presenta un gruppo sulfonato, che ne migliora la solubilità in soluzioni acquose, e una parte di maleimide che reagisce selettivamente con gruppi tiolici nei residui di cisteina delle proteine. Questa specificità consente modifiche precise delle biomolecole, consentendo ai ricercatori di studiare interazioni, stabilità e funzione delle proteine. Inoltre, Sulfo-SMCC sodio è caratterizzato da condizioni di reazione delicate, rendendolo adatto per l'uso con molecole biologiche sensibili. Devono essere osservate precauzioni di sicurezza quando si maneggia questo reagente, come con qualsiasi sostanza chimica, per ridurre al minimo l'esposizione e garantire pratiche di laboratorio adeguate.

Formula: C₁₆H₁₇N₂NaO₉S

InChI: InChI=1/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1/rC16H17N2NaO9S/c19-28-29(25,26)11-7-14(22)18(15(11)23)27-16(24)10-3-1-9(2-4-10)8-17-12(20)5-6-13(17)21/h5-6,9-11H,1-4,7-8H2

InChI key: InChIKey=VRMVBDHSLMDJAD-UHFFFAOYSA-N

SMILES: O(C(=O)C1CCC(CN2C(=O)C=CC2=O)CC1)N3C(=O)C(S(=O)(=O)O)CC3=O.[Na]

Sinonimi:

• 3-Pyrrolidinesulfonic acid, 1-[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]oxy]-2,5-dioxo-, sodium salt
• Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt (1:1)
• SMCC, Water-Soluble
• Sulfo-SMCC sodium
• Sulfo-Smcc
• Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• [1-[4-[(2,5-Dioxopyrrol-1-Yl)Methyl]Cyclohexanecarbonyl]Oxy-2,5-Dioxo-Pyrrolidin-3-Yl]Sulfonyloxysodium
• SULFO-SMCC SulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)cyclohexane-1-carboxylate
• Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate
• 3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-Cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1)
• 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester
• SULFOSUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
• Sulpho SMCC sodium salt
• SULFO SUCCINIMIDYL-4-(N-MALEIMIDO METHYL) CYCLOHEXANE-1-CARBOXYLATE
• Sulfo-SMCCSulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)
• Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate
• 3-Sulfo-N-succiniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate SodiuM Salt
• 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID 3-SULFO-N-HYDROXYSUCCINIMIDE ESTER SODIUM SALT
• Sulfo-N-Succinimidyl-4-(malemidonethyl)cyclohexane-1-carboxylate,sodium salt
• Sulfo-SMCC SodiuM Salt
• 4-(MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)Methyl]cyclohexanecarboxylic Acid 2,5-Dioxo-3-sulfo-1-pyrrolidinyl Ester, SodiuM Salt
• SULFO-N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE, SODIUM SALT
• Sulfo-SMCC Crosslinker
• SulfosucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate(Sulfo-SMCC)

3-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt

CAS: 92921-24-9

Formula: C₁₆H₁₇N₂NaO₉S

Purezza: >97.0%(qNMR)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 436.37

Ref: 3B-S0883

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt, 97+%

CAS: 92921-24-9

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt is a cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second co

Formula: C₁₆H₁₇N₂NaO₉S

Purezza: 97+%

Colore e forma: Off-white to white, Solid

Peso molecolare: 436.37

Ref: 02-H54807

Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate, Sodium Salt

CAS: 92921-24-9

Formula: C₁₆H₁₇N₂NaO₉S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 436.3689

Ref: IN-DA006K94

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

CAS: 92921-24-9

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

Purezza: 95%

Peso molecolare: 436.37g/mol

Ref: 54-OR1030515

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium

Purezza: ≥98%

Peso molecolare: 436.37g/mol

Ref: 54-BUP11004

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

CAS: 92921-24-9

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

Formula: C₁₆H₁₇N₂O₉S·Na

Purezza: 98% (Typical Value in Batch COA)

Colore e forma: white solid

Peso molecolare: 436.37g/mol

Ref: 54-BICL207

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium: hetero-bifunctional ADC crosslinker with NHS ester and maleimide for amines and sulfhydryls.

Formula: C₁₆H₁₇N₂NaO₉S

Purezza: 98.07% - 99.9%

Colore e forma: Solid

Peso molecolare: 436.37

Ref: TM-T18728

Sulfo-SMCC sodium

CAS: 92921-24-9

Crosslinker reacting rapidly with primary amines.  It is used as a protein crosslinker where it reacts with cysteine to yield specific conjugates.  The cyclohexane bridge confers added stability to the maleimide group making it ideal for maleimide activation of proteins.  It is soluble in water and many other aqueous buffers although it is less stable then in DMSO or DMF.

Formula: C₁₆H₁₇N₂O₉SNa

Purezza: Min. 95 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 436.37 g/mol

Ref: 3D-FS27953

Sulfo-SMCC sodium

CAS: 92921-24-9

Purezza: 96%

Peso molecolare: 436.3699951

Ref: 10-F869416