CAS 936563-96-1

1-((3r)-3-(4-amino-3-(4-fenossifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-one

Descrizione:

La sostanza chimica nota come 1-((3r)-3-(4-amino-3-(4-fenossifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-one, con il numero CAS 936563-96-1, è un composto organico complesso caratterizzato dalla sua struttura multifunzionale. Presenta un nucleo di pirazolo-pirimidina, noto per la sua attività biologica, in particolare in chimica medicinale. La presenza di un gruppo amminico e di un moiety fenossifenilico suggerisce potenziali interazioni con bersagli biologici, rendendolo un candidato per applicazioni farmaceutiche. L'anello di piperidina contribuisce alla sua basicità e può influenzare le sue proprietà farmacocinetiche. Inoltre, il gruppo carbonilico α,β-insaturo (2-propen-1-one) è significativo per la reattività, consentendo potenzialmente ulteriori modifiche chimiche. In generale, la struttura intricata di questo composto indica un potenziale per diverse attività biologiche, giustificando ulteriori indagini nello sviluppo di farmaci e nelle applicazioni terapeutiche.

Formula: C₂₅H₂₄N₆O₂

InChI: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1

InChI key: InChIKey=XYFPWWZEPKGCCK-GOSISDBHSA-N

SMILES: NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1

Sinonimi:

• (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-propenone
• 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-
• Cra 032765
• Ibrutinib
• Imbruvica
• Jnj 02
• Pci 32765-00
• Pci-32765
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• PCI-32765 (Ibrutinib)
• Ibrutinib (PCI-32765)
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one

1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

CAS: 936563-96-1

Formula: C₂₅H₂₄N₆O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 440.4971

Ref: IN-DA003620

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Purezza: 98%

Peso molecolare: 440.5g/mol

Ref: 54-OR1029554

Ibrutinib (PCI-32765)

CAS: 936563-96-1

Formula: C₂₅H₂₄N₆O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 440.51

Ref: 4Z-I-061003

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Purezza: ≥98%

Peso molecolare: 440.5g/mol

Ref: 54-BUP15079

Ibrutinib

CAS: 936563-96-1

Formula: C₂₅H₂₄N₆O₂

Purezza: ≥ 98.0%

Colore e forma: White or almost white powder

Peso molecolare: 440.50

Ref: 7W-GP8742

Ibrutinib

Prodotto controllato

CAS: 936563-96-1

Formula: C₂₅H₂₄N₆O₂

Colore e forma: Neat

Peso molecolare: 440.50

Ref: 86-MM3746.00

Ibrutinib

CAS: 936563-96-1

Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.

Formula: C₂₅H₂₄N₆O₂

Purezza: 98% - 99.93%

Colore e forma: Solid

Peso molecolare: 440.5

Ref: TM-T1835

Ibrutinib

Prodotto controllato

CAS: 936563-96-1

Applications Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Formula: C₂₅H₂₄N₆O₂

Colore e forma: Off-White

Peso molecolare: 440.50

Ref: TR-I124970

Ibrutinib-d4 (Major)

Prodotto controllato

CAS: 936563-96-1

Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Formula: C₂₅H₂₀D₄N₆O₂

Colore e forma: Neat

Peso molecolare: 444.52

Ref: TR-I124971

Ibrutinib

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Formula: C₂₅H₂₄O₂N₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 440.5 g/mol

Ref: 3D-FA34130

Ibrutinib - Bio-X ™

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Formula: C₂₅H₂₄O₂N₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 440.5 g/mol

Ref: 3D-BI164531

Ibrutinib

CAS: 936563-96-1

Purezza: 99%

Peso molecolare: 440.51

Ref: 10-F799864