CAS 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Descrizione:

Suc-Leu-Leu-Val-Tyr-AMC, noto anche come substrato peptidico, è un composto sintetico che consiste in una sequenza di amminoacidi: leucina succinilata, leucina, valina, tirosina e 7-amido-4-metilcumarina (AMC). Questo composto è utilizzato principalmente in saggi biochimici per studiare enzimi proteolitici, in particolare quelli che rompono legami peptidici. Il gruppo succinilico migliora la solubilità e la stabilità del peptide, mentre la parte AMC funge da reporter fluorescente, consentendo la rilevazione dell'attività enzimatica attraverso misurazioni di fluorescenza. Le caratteristiche di questa sostanza includono la sua capacità di subire idrolisi da parte di proteasi specifiche, con conseguente rilascio di AMC, che può essere misurato quantitativamente. Questa proprietà la rende preziosa nelle applicazioni di ricerca, in particolare nei campi dell'enzimologia e della scoperta di farmaci. Inoltre, la struttura di Suc-Leu-Leu-Val-Tyr-AMC contribuisce alla sua specificità per alcune enzimi, rendendola uno strumento utile per studiare la cinetica enzimatica e l'inibizione.

Formula: C₄₀H₅₃N₅O₁₀

InChI: InChI=1/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29?,30?,31-,36-/m0/s1

SMILES: CC(C)CC(C(=NC(CC(C)C)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)O)N=C(CCC(=O)O)O

Sinonimi:

• N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma
• Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
• Llvy-mca
• N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin
• Sllvt-mca
• Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin
• Suc-leu-leu-val-tyr-mca
• Suc-llvy-mca
• L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

Formula: C₄₀H₅₃N₅O₁₀

Purezza: > 98%

Colore e forma: White

Peso molecolare: 763.89

Ref: 01-4011369

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Formula: C₄₀H₅₃N₅O₁₀

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 763.8763

Ref: IN-DA01E5Y8

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.

Formula: C₄₀H₅₃N₅O₁₀

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 763.88

Ref: TM-TP1308

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS: 94367-21-2

Formula: C₄₀H₅₃N₅O₁₀

Purezza: ≥ 95.0%

Colore e forma: White to off-white powder

Peso molecolare: 763.89

Ref: 7W-GL1880

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a peptide that is an activator of ion channels. It can be used to study the effects of ion channel activation on various cells and tissues. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to inhibit ligand binding to some receptors, such as the acetylcholine receptor. This peptide can also be used as a research tool for pharmacology, protein interactions, and antibody production.

Formula: C₄₀H₅₃N₅O₁₀

Purezza: Min. 95%

Peso molecolare: 763.88 g/mol

Ref: 3D-MLL-3120-V

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a cyclin D2 inhibitor that binds to the proteasome and inhibits its function. It has been shown to be useful for the treatment of cancerous tissues as it inhibits the production of prostaglandin J2, which is involved in the progression of cancer cells. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to have antioxidant properties and can inhibit oxidative injury. This drug may be used to prevent or treat various diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, diabetes mellitus type II, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and septic shock.

Formula: C₄₀H₅₃N₅O₁₀

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 763.88 g/mol

Ref: 3D-FS110535