CAS 957230-65-8

Isofagomine D-Tartrate

CAS: 957230-65-8

Formula: C₆H₁₃NO₃·C₄H₆O₆

Peso molecolare: 147.17 150.09

Ref: 4Z-F-103003

Isofagomine D-Tartrate

CAS: 957230-65-8

Stability Very Hygroscopic
Applications Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.
References Zhou, Z., et al.: J. Biol. Chem., 274, 31123 (1999), Pandey, G., et al.: Tetrahedron lett., 41, 8821, (2000).

Formula: C₆H₁₃NO₃·C₄H₆O₆

Colore e forma: Neat

Peso molecolare: 297.26

Ref: TR-I816010

Isofagomine D-tartrate

CAS: 957230-65-8

Inhibitor of lysosomal acid β-glucosidase (GlcCerase/glucocerebrosidase) with IC50 in nanomolar range for wildtype and mutant enzyme. It behaves as pharmacological chaperon by binding to instable GlcCerase active site at neutral pH values and facilitating the protein folding. In acidic lysosomes, isofagomine gets release from the enzyme active site. This results in increased levels of functional glucocerebrosidase and brings therapeutic benefits to patients with Gaucher disease.

Formula: C₁₀H₁₉NO₉

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 297.26 g/mol

Ref: 3D-MI24675

Afegostat D-Tartrate

CAS: 957230-65-8

Afegostat D-Tartrate: pharmacological chaperone, reversibly binds acid-β-glucosidase in ER with high affinity.

Formula: C₁₀H₁₉NO₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 297.26

Ref: TM-T19182