CAS 96736-12-8

L-Leucinamide, D-arginil-L-prolil-L-lisil-L-prolil-D-fenilalanil-L-glutaminil-D-triptofanil-L-fenilalanil-D-triptofanil-L-leucil-

Descrizione:

L-Leucinamide, D-arginil-L-prolil-L-lisina-L-prolil-D-fenilalanina-L-glutamina-D-triptofano-L-fenilalanina-D-triptofano-L-leucina è un peptide complesso composto da vari aminoacidi, inclusi sia enantiomeri L che D. Questa struttura suggerisce che potrebbe presentare proprietà biologiche uniche a causa della presenza di entrambe le forme di aminoacidi, che possono influenzare le sue interazioni con i sistemi biologici. La presenza di più residui di prolina può contribuire alla sua stabilità strutturale e al potenziale di formare conformazioni specifiche. La sequenza del peptide indica un potenziale ruolo nei processi biologici, possibilmente legato a funzioni di segnalazione o strutturali nelle proteine. Il suo numero CAS, 96736-12-8, consente un'identificazione precisa nei database chimici. Tuttavia, informazioni dettagliate sulla sua solubilità, stabilità e attività biologiche specifiche richiederebbero studi empirici, poiché queste caratteristiche possono variare significativamente in base alla conformazione e all'ambiente del peptide. In generale, questo composto rappresenta un'area affascinante di studio nella chimica dei peptidi e nella biochimica.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Sinonimi:

• SubstanceP,1-D-arginine-5-D-phenylalanine-7-D-tryptophan-9-D-tryptophan-11-L-leucinamide-
• L 756867
• [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
• D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 96736-12-8

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC₅₀ = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity. So, Asakawa et al. found that peripherally administered H-6395 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purezza: 98.2%

Colore e forma: White Lyophilisate

Peso molecolare: 1516.86

Ref: 01-4013823

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1516.85

Ref: TM-TP1931

[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P

CAS: 96736-12-8

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purezza: ≥ 95.0%

Colore e forma: White powder

Peso molecolare: 1516.83

Ref: 7W-GL9471

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that belongs to the Feeding Regulatory Peptides family. It is synthesized in the hypothalamus and secreted by neurons in the spinal cord, brainstem, and gut. Substance P has been shown to regulate feeding behavior through its interaction with opioid receptors and the release of other neurotransmitters. The synthetic form of this peptide has been shown to reduce body fat in animal models and increased sensitivity to insulin in diabetic patients. This peptide also reduces camp levels in rats, which may be due to its ability to stimulate secretion of camp from pancreatic cells.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purezza: Min. 95%

Peso molecolare: 1,516.87 g/mol

Ref: 3D-PGH-3652-PI

(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that binds to the tachykinin receptor NK1. It has potent anti-inflammatory and mitogenic activities, which are mediated through its binding to the NK1 receptor. Substance P can stimulate lung cancer cells to proliferate and inhibit their apoptosis, which may be due to an autocrine mechanism. In addition, it has been shown that substance P can potentiate the growth of some cancers such as colon cancer in vitro and in vivo by increasing DNA synthesis and cell proliferation. This peptide also has a dose-dependent effect on cell growth, with high doses inhibiting cell proliferation at higher levels than low doses.

Formula: C₇₉H₁₀₉N₁₉O₁₂

Purezza: Min. 95%

Peso molecolare: 1,516.83 g/mol

Ref: 3D-FA109992