CAS 98796-51-1

Timidina, 5'-O-[bis(4-metossifenil)fenilmetile]-, 3'-[2-cianoetile N,N-bis(1-metiletil)fosforamidite]

Descrizione:

Timidina, 5'-O-[bis(4-metossifenil)fenilmetile]-, 3'-[2-cianoetile N,N-bis(1-metiletil)fosforamidite], comunemente riferito con il suo numero CAS 98796-51-1, è un derivato nucleosidico sintetico utilizzato principalmente nel campo della biologia molecolare e della biochimica. Questo composto presenta una base di timidina, che è un componente del DNA, modificata nelle posizioni 5' e 3'. La posizione 5' è sostituita da un gruppo bis(4-metossifenile)fenilmetile, che ne migliora la stabilità e la solubilità, mentre la posizione 3' è modificata con un moiety di fosforamidito cianoetilico, che è cruciale per il suo ruolo nella sintesi di oligonucleotidi. La presenza del gruppo fosforamidito consente l'incorporazione di questo composto in catene di DNA durante la sintesi in fase solida, rendendolo prezioso per la produzione di oligonucleotidi personalizzati per applicazioni di ricerca e terapeutiche. Le sue caratteristiche strutturali contribuiscono alla sua reattività e utilità in vari processi biochimici, in particolare nella sintesi di analoghi di DNA e RNA.

Formula: C₄₀H₄₉N₄O₈P

InChI: InChI=1/C10H14N2O5.C3H6N2O2P/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8;1-3(2-4)7-8(5)6/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16);3H,5H2,1H3/q;-1/t6-,7+,8+;/m0./s1

InChI key: InChIKey=UNOTXUFIWPRZJX-CEXSRUIHSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@@H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Sinonimi:

• 5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-cyanoethyl Phosphoramidite
• 5′-O-(4,4′-Dimethoxytrityl)thymidine 3′-(2-cyanoethyl-N,N-diisopropylphosphoramidite)
• 5′-O-(4,4′-Dimethoxytriyl)thymidine 3′-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
• 5′-O-DMT-thymidine 3′-CE phosphoramidite
• DMT-dT phosphoramidite
• DNA T Phosphoramidite
• DT-CE phosphoramidite
• Deoxythymidine phosphoramidite
• Thymidine phosphoramidite
• Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• dT Phosphoramidite
• DMT-dT Amidite 1g, 60ml vial, 12 Pack
• DMT-dT amidite
• T-CE phosphoramidite
• 5'-DMT-dT phosphoramidite
• 5'-O-(4,4'-Dimethoxytrityl)thymidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
• thymidine-ce phosphoramidite for*biosearch 8000
• 3'-O-P-5'-O-DMT-2'-DEOXY-THYRIDINE [DT PHOSPHORAMIDITE]
• 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-thymidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• DMT-DT AMIDITE 1G AB 12 PACK
• 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
• 5'-O-DMT-2'-deoxythymidine-3'-CE Phosphoramidite
• DMT-dT Amidite 2g, 60ml vial, 12 Pack
• 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• DMT-DT AMIDITE 2G 89 12 PACK
• REF DUPL: dT Phosphoramidite
• 5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-thyMidine 3'-[2-cyanoethyl N,N-bis(1-Methylethyl)phosphoraMidite]
• 5'-O-Dimethoxytrityl-2'-deoxy-thymidine-3'-O-(2-cyanoethyl)-Phosphoramidite
• N-blocked-5'-O-DMT 3'-CED thymidine phosphoramidite
• DMT-dT-CE-Phosphoramidite
• DMT-DT AMIDITE 10G SINGLE
• (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-de5'-O-DMT-Thymidine 3'-CE phosphoramidite
• DMT-dT Amidite 6.85g, 6 Pack
• 5'-O-DMT- 2'-Deoxy Thymidine Phosphoramidite
• DMT-DT AMIDITE 5G SINGLE
• DMT-DT AMIDITE 4G 60ML VIAL 12 PACK
• 5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• DMT-DT AMIDITE 2G AB 12 PACK
• DMT-dT Pharmadite
• Thymidine-3'-phosphoramidite
• DMT-DT AMIDITE 5G 6 PACK
• DMT-THYMIDINE CED PHOSPHORAMIDITE
• 5''-O-(4,4''-Dimethoxytrityl)-thymidine-3''-N,N-diisopropyl-(2-cyanoethyl)-pho
• DNAT-PHOSPHORAMIDITE
• 5'-O-(DIMETHOXYTRITYL)-THYMIDINE-3'-N,N-DIISOPROPYL(CYANOETHYL)PHOSPHORAMIDITE
• DMT-DT AMIDITE 20G 6 PACK

DMT-dT Phosphoramidite

CAS: 98796-51-1

Formula: C₄₀H₄₉N₄O₈P

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 744.83

Ref: 3B-D5702

T β-Cyanoethyl Phosphoramidite (5'-O-Dimethoxytritylthymidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)

CAS: 98796-51-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₄₀H₄₉N₄O₈P

Colore e forma: White Powder

Peso molecolare: 744.3288

Ref: 45-1152031

Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]

CAS: 98796-51-1

Formula: C₄₀H₄₉N₄O₈P

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 744.8128

Ref: IN-DA00IMLR

5''-O-DMT-thymidine 3''-CE phosphoramidite

CAS: 98796-51-1

Ref: 7W-GN6430

Dmt-dT Phosphoramidite

CAS: 98796-51-1

Dmt-dT Phosphoramidite

Purezza: 98%

Peso molecolare: 744.81g/mol

Ref: 54-OR1013057

DMT-dT Phosphoramidite

CAS: 98796-51-1

DMT-dT Phosphoramidite is typically used in the synthesis of DNA.

Formula: C₄₀H₄₉N₄O₈P

Colore e forma: Solid

Peso molecolare: 744.81

Ref: TM-T41131

5'-O-DMT-thymidine 3'-CE phosphoramidite

CAS: 98796-51-1

5'-O-DMT-thymidine 3'-CE phosphoramidite is a building block for the introduction of thymidine units into oligonucleotides. 5'-O-DMT-thymidine 3'-CE phosphoramidite is utilised in a broad range of applications, including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.

Formula: C₄₀H₄₉N₄O₈P

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 744.83 g/mol

Ref: 3D-PD09152

DMT-dT Phosphoramidite

CAS: 98796-51-1

Purezza: 97%

Peso molecolare: 744.826

Ref: 10-F988390

DMT-dT Phosphoramidite

CAS: 98796-51-1

Formula: C₄₀H₄₉N₄O₈P

Peso molecolare: 744.81

Ref: ST-EA-CP-C151019