CAS 99533-80-9

(+)-K 252a

Descrizione:

(+)-K 252a è un prodotto naturale derivato dalla fermentazione del batterio Streptomyces, noto per le sue potenti attività biologiche. È classificato come un inibitore della chinasi proteica, mirato specificamente a varie chinasi coinvolte nelle vie di segnalazione cellulare. Questo composto presenta una struttura complessa caratterizzata da un nucleo tetraciclico, che contribuisce alla sua capacità di modulare processi cellulari come crescita, differenziazione e apoptosi. (+)-K 252a ha mostrato promesse in varie applicazioni farmacologiche, inclusi effetti neuroprotettivi e potenziali proprietà antitumorali. Il suo meccanismo d'azione implica l'inibizione di chinasi specifiche, il che può portare a modifiche nelle cascades di segnalazione cellulare. Inoltre, è stato studiato per i suoi effetti sul rilascio di neurotrasmettitori e sulla sopravvivenza neuronale. A causa della sua importanza biologica, (+)-K 252a funge da strumento prezioso nella ricerca biochimica e ha potenziali implicazioni terapeutiche, sebbene siano necessari ulteriori studi per comprendere appieno la sua efficacia e sicurezza in contesti clinici.

Formula: C₂₇H₂₁N₃O₅

InChI: InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key: InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)O)[H])=CC=CC8

Sinonimi:

• (+)-K 252a
• 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-
• 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-
• Antibiotic K 252a
• Antibiotic SF 2370
• K 252
• K 252a Nocardiopsis sp.
• K252a
• Protein kinase inhibitor K252a
• Sf 2370
• methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate

K-252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purezza: 100.0%

Colore e forma: Yellowish amorphous solid

Peso molecolare: 467.0

Ref: 8R-JU0109

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 467.4727

Ref: IN-DA00655S

K252a

CAS: 99533-80-9

K252a

Formula: C₂₇H₂₁N₃O₅

Purezza: By hplc: 99.23% (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 467.47g/mol

Ref: 54-BIK1001

K-252a

CAS: 99533-80-9

K-252a, staurosporine analog, inhibits various kinases (PKC 470nM, PKA 140nM, CaMKII 270nM, PhK 1.7nM), from Nocardiopsis sp. soil fungi.

Formula: C₂₇H₂₁N₃O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 467.47

Ref: TM-T15636

K-252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 467.47

Ref: 7W-GL3770

K252a

Prodotto controllato

CAS: 99533-80-9

Applications K252a is a protein kinase inhibitor. It is an analogue of staurosporine (S685000). It shows potent antitumor activity but no antimicrobial activity in vitro, or in vivo toxicity in rodents.
References Kase, H., et al.: J. Antibiot., 39, 1059 (1986); Yasuzawa, T., et al.; J. Antibiot., 39, 1072 (1986)

Formula: C₂₇H₂₁N₃O₅

Colore e forma: Neat

Peso molecolare: 467.47

Ref: TR-K000500

K252a

CAS: 99533-80-9

Inhibitor of TRK family of kinases

Formula: C₂₇H₂₁N₃O₅

Purezza: Min. 95%

Peso molecolare: 467.47 g/mol

Ref: 3D-FK45548

K252a

CAS: 99533-80-9

Formula: C₂₇H₂₁N₃O₅

Peso molecolare: 467.48

Ref: 4Z-K-021001

K-252A

CAS: 99533-80-9

K-252A is an antimicrobial agent that inhibits the growth of bacteria. It binds to the response element in the promoter region of genes and blocks gene transcription, thereby preventing protein synthesis. K-252A has been shown to inhibit the growth of bacteria that are resistant to many other antibiotics, including ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin and kanamycin. This drug also induces significant up-regulation of cyclic nucleotide phosphodiesterases (PDE) and cytosolic Ca2+ in vitro. K-252A has been shown to cause neuronal death in vitro by inhibiting axonal growth. K-252A also inhibits leukemia inhibitory factor (LIF) from binding to its receptor on mouse lymphocytes.

Formula: C₂₇H₂₁N₃O₅

Purezza: Min. 95%

Peso molecolare: 467.49 g/mol

Ref: 3D-INK-3026-PI