Canale ionico

Voltage-dependent K+ channel opener; insulinotropic sulfonylurea receptor ligand

Oxcarbazepine metabolite; anticonvulsant; sodium channel blocker

Amlodipine is a calcium channel blocker that is used to treat hypertension and angina. This drug inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle.

Nateglinide is used to treat type 2 diabetes mellitus as an oral hypoglycemic, insulinotropic agent. It is a blocker of ATP-dependent potassium channels and works by increasing the body's production of insulin, which lowers blood glucose levels. Nateglinide has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes who have not responded well to other treatments. The effects of nateglinide are reversible.

Amiodarone a class III anti-arrhythmic agent, used to treat and prevent certain types of irregular heartbeats. It is a competitor for natural ligands of alpha and beta adrenergic receptors, muscarinic acetylcholine receptors, histamine H1 receptors, and serotonin 5HT2A/5HT2C receptors. Amiodarone has been shown to reduce the number of atrial and ventricular arrhythmias in patients with structural heart disease, and has been used to treat atrial fibrillation, ventricular tachycardia, and Wolff-Parkinson-White Syndrome. It has also been used in the prevention of myocardial infarcts due to its ability to modify blood pressure and maintain cardiac function. In addition, amiodarone inhibits prostaglandin synthesis by inhibiting cyclooxygenase enzymes. This prevents inflammation in the gastrointestinal tract and reduces bowel disease symptoms such as cramping or diarrhea.

Antagonist of NMDA glutamate receptor at glycine binding site

Sodium channel blocker; anti-arrhythmic agent

Antagonist of serotonin receptors 5-HT3

Suzetrigine is a novel compound classified as a synthetic ligand, which is derived through advanced chemical synthesis techniques. This compound engages specific targets within biological systems, acting primarily as a selective modulator of ion channels.

Sodium channel inhibitor; inhibitor of urokinase-type plasminogen activator

Oxcarbazepine is an anti-epileptic drug that is used for the treatment of partial-onset seizures. Although, the mechanism of action for this drug is unclear, it is said to involve the blockage of voltage-gated sodium channels. As a result, the firing of the action potentials which lead to seizures are reduced and so seizure activity is inhibited.

nAChRs nicotinic receptor antagonist; neuromuscular-blocking agent