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Bcr-Abl

Bcr-Abl

Gli inibitori di Bcr-Abl sono terapie mirate che inibiscono la proteina di fusione Bcr-Abl, formata a seguito della traslocazione del cromosoma Philadelphia e responsabile della leucemia mieloide cronica (CML). Questa proteina influenza anche l'angiogenesi, contribuendo alla progressione tumorale. Gli inibitori di Bcr-Abl sono cruciali nel trattamento della CML e sono oggetto di ricerca per il loro potenziale nell'inibire l'angiogenesi in vari tipi di cancro. Presso CymitQuimica, offriamo inibitori di Bcr-Abl di alta qualità per supportare la tua ricerca in biologia del cancro, angiogenesi e terapie mirate.

Trovati 117 prodotti di "Bcr-Abl"

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  • BCR-ABL-IN-5
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    BCR-ABL-IN-5

    CAS:
    BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.
    Formula:C25H21Cl2N5O2
    Colore e forma:Solid
    Peso molecolare:494.37

    Ref: TM-T63332

  • CHMFL-ABL-053
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    CHMFL-ABL-053

    CAS:
    CHMFL-ABL-053: potent, selective BCR-ABL/SRC/p38 inhibitor (IC50: 70/90/62 nM). Orally available, potential CML drug.
    Formula:C28H26F3N7O2
    Colore e forma:Solid
    Peso molecolare:549.55

    Ref: TM-T22067

  • AFG210
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    AFG210

    CAS:
    AFG210 is a novel first-generation “type II” FLT3 inhibitor.
    Formula:C19H14F3N3O2
    Colore e forma:Solid
    Peso molecolare:373.33

    Ref: TM-T69702

  • BCR-ABL1-IN-1
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    BCR-ABL1-IN-1

    CAS:
    BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.
    Formula:C18H12F3N3O2
    Colore e forma:Solid
    Peso molecolare:359.3

    Ref: TM-T61324

  • AP 24149
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    AP 24149

    CAS:
    AP 24149, a potent dual inhibitor targeting Src and Abl, exhibits IC50 values of 9.1 nM for Src and 3.6 nM for Abl, respectively.
    Formula:C23H24N5OP
    Colore e forma:Solid
    Peso molecolare:417.44

    Ref: TM-T73345

  • BCR-ABL-IN-2
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    BCR-ABL-IN-2

    CAS:
    BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).
    Formula:C24H25Cl2N5O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:502.39

    Ref: TM-T10489

  • BCR-ABL-IN-7
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    BCR-ABL-IN-7

    CAS:
    BCR-ABL-IN-7 is an inhibitor of ABL kinase activity in WT and T315I mutants.BCR-ABL-IN-7 can be used in chronic myeloid leukemia (CML) research.
    Formula:C19H16FN3O3S
    Purezza:98.28%
    Colore e forma:Solid
    Peso molecolare:385.41

    Ref: TM-T72958

  • CpCDPK1/TgCDPK1-IN-1
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    CpCDPK1/TgCDPK1-IN-1

    CAS:
    CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.
    Formula:C18H17N5
    Purezza:99.61%
    Colore e forma:Solid
    Peso molecolare:303.36

    Ref: TM-T78605

  • PF-06651481-00
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    PF-06651481-00

    CAS:
    <p>PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.</p>
    Formula:C26H29Cl2N5O3
    Purezza:97.01%
    Colore e forma:Solid
    Peso molecolare:530.45

    Ref: TM-T28374

  • BCR-ABL-IN-1
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    BCR-ABL-IN-1

    CAS:
    BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
    Formula:C23H21F4N5O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:459.44

    Ref: TM-T10488

  • Antiproliferative agent-30
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    Antiproliferative agent-30

    CAS:
    Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against
    Formula:C24H26N4O4
    Colore e forma:Solid
    Peso molecolare:434.49

    Ref: TM-T79322

  • c-ABL-IN-2
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    c-ABL-IN-2

    CAS:
    C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.
    Formula:C21H20N4O
    Colore e forma:Solid
    Peso molecolare:344.41

    Ref: TM-T61128

  • Debio 0617B
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    Debio 0617B

    CAS:
    Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.
    Formula:C28H23ClF3N7O2
    Colore e forma:Solid
    Peso molecolare:581.98

    Ref: TM-T64110

  • BGB659
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    BGB659

    CAS:
    BGB659 is effective inhibitor of RAF.
    Formula:C29H29F3N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:538.56

    Ref: TM-T23786

  • Tyrphostin AG 568
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    Tyrphostin AG 568

    CAS:
    Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.
    Formula:C13H9N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:267.24

    Ref: TM-T24912

  • ON 146040
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    ON 146040

    CAS:
    ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
    Formula:C24H23N7O3S
    Purezza:97.39%
    Colore e forma:Solid
    Peso molecolare:489.55

    Ref: TM-T12310

  • PD-173956
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    PD-173956

    CAS:
    PD-173956 is an inhibitor of the Src family tyrosine kinases.
    Formula:C20H13Cl2FN4O
    Colore e forma:Solid
    Peso molecolare:415.25

    Ref: TM-T28345

  • AN-019
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    AN-019

    CAS:
    AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.
    Formula:C25H17F6N5O
    Purezza:98.99%
    Colore e forma:Solid
    Peso molecolare:517.43

    Ref: TM-T26625

  • BCR-ABL-IN-6
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    BCR-ABL-IN-6

    CAS:
    BCR-ABL-IN-6, an imatinib derivative, inhibits Bcr-AblWT (4.6 nM IC50) and T315I (277 nM), for chronic myeloid leukemia study.
    Formula:C27H22F3N5O2
    Colore e forma:Solid
    Peso molecolare:505.49

    Ref: TM-T63450

  • Nilotinib hydrochloride
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    Nilotinib hydrochloride

    CAS:
    Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.
    Formula:C28H23ClF3N7O
    Purezza:99.98%
    Colore e forma:Solid
    Peso molecolare:565.98

    Ref: TM-T22378