EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 581 prodotti di "EGFR"
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Tyrphostin AG 528
CAS:Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Formula:C18H14N2O3Purezza:99.64%Colore e forma:SolidPeso molecolare:306.32Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purezza:97.18%Colore e forma:SolidPeso molecolare:308.33Ref: TM-T22450
1mg39,00€5mg82,00€10mg115,00€25mg192,00€50mg264,00€100mg380,00€200mg515,00€1mL*10mM (DMSO)90,00€AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purezza:98% - >99.99%Colore e forma:SolidPeso molecolare:440.58Ref: TM-T2116
2mg47,00€5mg70,00€10mg103,00€25mg188,00€50mg325,00€100mg490,00€500mg1.103,00€1mL*10mM (DMSO)77,00€Derazantinib dihydrochloride
CAS:Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Formula:C29H31Cl2FN4OColore e forma:SolidPeso molecolare:541.49Olafertinib
CAS:Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.Formula:C29H28F2N6O2Purezza:98.62% - 99.706%Colore e forma:SolidPeso molecolare:530.57Allitinib tosylate
CAS:Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Formula:C31H26ClFN4O5SPurezza:98.46% - 98.68%Colore e forma:SolidPeso molecolare:621.08CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Formula:C18H13BrN4OPurezza:99.56% - 99.62%Colore e forma:SolidPeso molecolare:381.23E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurezza:99.31% - 99.87%Colore e forma:SolidPeso molecolare:474.44WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purezza:97.93% - 99.94%Colore e forma:SolidPeso molecolare:569.58WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purezza:99.21%Colore e forma:SolidPeso molecolare:297.31Naquotinib
CAS:Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFormula:C30H42N8O3Purezza:97.49%Colore e forma:SolidPeso molecolare:562.71PD153035 hydrochloride
CAS:PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.
Formula:C16H15BrClN3O2Purezza:99.39% - ≥95%Colore e forma:SolidPeso molecolare:396.67NRC-2694 hydrochloride
CAS:NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Formula:C24H27ClN4O3Colore e forma:SolidPeso molecolare:454.95Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purezza:99.22%Colore e forma:SolidPeso molecolare:561.03Ref: TM-T9072
2mg38,00€5mg57,00€10mg90,00€25mg178,00€50mg334,00€100mg497,00€200mg712,00€1mL*10mM (DMSO)71,00€AG1557
CAS:AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
Formula:C16H14IN3O2Purezza:98.61% - 99.23%Colore e forma:SolidPeso molecolare:407.21WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C29H31F3N6O3Purezza:97.65% - 99.95%Colore e forma:SolidPeso molecolare:568.59TAS6417
CAS:Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C23H20N6OPurezza:99.71%Colore e forma:SolidPeso molecolare:396.44Ref: TM-T16996
1mg93,00€2mg117,00€5mg178,00€10mg295,00€25mg595,00€50mg795,00€100mg1.071,00€200mg1.468,00€1mL*10mM (DMSO)203,00€CP-724714
CAS:CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2
Formula:C27H27N5O3Purezza:97.1% - 98.82%Colore e forma:SolidPeso molecolare:469.54(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formula:C29H35ClFN7O3Purezza:99.64%Colore e forma:SolidPeso molecolare:584.08PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Formula:C18H14ClFN4O2Purezza:97.71%Colore e forma:SolidPeso molecolare:372.78Ref: TM-T22396
2mg38,00€5mg57,00€10mg96,00€25mg177,00€50mg333,00€100mg495,00€500mg1.071,00€1mL*10mM (DMSO)63,00€
