EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 591 prodotti di "EGFR"
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EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Colore e forma:Odour SolidBefotertinib
CAS:Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Formula:C29H32F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:567.61Ref: TM-T39275
1mg88,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.026,00€1mL*10mM (DMSO)235,00€Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedColore e forma:Odour SolidRef: TM-L2200
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaHDS 029
CAS:HDS 029 has a wide range of applications in life science related research.Formula:C17H11ClFN5OColore e forma:SolidPeso molecolare:355.76Anti-ERBB3/HER3 (29Z6)
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor targeting human ERBB3/HER3.Colore e forma:Odour LiquidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidSJF 1528
CAS:Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).Formula:C55H57ClFN7O8SColore e forma:SolidPeso molecolare:1030.61CN009543V
CAS:CN009543V is an enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways.Formula:C12H12N4O6SColore e forma:SolidPeso molecolare:340.31ZM 449829
CAS:ZM 449829: Selective JAK3 inhibitor, binds to ATP site. pIC50: 6.8 for JAK3, others < 5.0.Formula:C13H10OPurezza:98%Colore e forma:SolidPeso molecolare:182.222MS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Formula:C50H59ClF4N8O14Colore e forma:SolidPeso molecolare:1107.5EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formula:C49H53ClFN5O5Colore e forma:SolidPeso molecolare:846.43MS9449
CAS:MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.Formula:C60H76ClFN10O8SPurezza:98%Colore e forma:SolidPeso molecolare:1151.82EP26
EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.Formula:C42H42ClFN4O5Peso molecolare:736.28278Modotuximab
CAS:Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Purezza:95.5% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.5% (SDS-PAGE); 99.3% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:146.45 kDaEGFR/VEGFR2-IN-5
EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.Formula:C17H15N7O5SColore e forma:SolidPeso molecolare:429.41Matuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Purezza:95%Colore e forma:LiquidPeso molecolare:145.9 kDaHER2-IN-14
CAS:HER2-IN-14 (Compound 34) is a potent inhibitor of HER2, achieving an inhibitory concentration (IC50) of 18 nM.Formula:C26H23ClF2N8O3Colore e forma:SolidPeso molecolare:568.96PROTAC EGFR degrader 3
CAS:Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Formula:C60H77N13O5SColore e forma:SolidPeso molecolare:1092.4Anticancer agent 158
Anticancer agent 158 (compound 7c) demonstrates potent efficacy against various cancer cell lines, with IC50 values of 7.93 μM for HepG-2, 9.28 μM for MDA-MB-Colore e forma:Odour SolidLyso-Monosialoganglioside GM3
CAS:Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.Formula:C41H74N2O20Colore e forma:SolidPeso molecolare:915.028
