EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 591 prodotti di "EGFR"
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EGFR-IN-28
CAS:EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formula:C31H39BrN10O3SColore e forma:SolidPeso molecolare:711.68RG 14467
CAS:RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formula:C14H14N2O3Colore e forma:SolidPeso molecolare:258.27UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formula:C18H14ClN3O2Colore e forma:SolidPeso molecolare:339.78BAY 2476568
CAS:BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formula:C24H27FN4O4Colore e forma:SolidPeso molecolare:454.49LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formula:C32H35N5O3Colore e forma:SolidPeso molecolare:537.65RG 14921
CAS:RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formula:C11H9NO3Colore e forma:SolidPeso molecolare:203.19AFN941
CAS:AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Formula:C28H30N4O3Colore e forma:SolidPeso molecolare:470.56CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formula:C29H25F3N6O3Colore e forma:SolidPeso molecolare:562.54Lavendustin C6
CAS:Lavendustin C6 is a effective tyrosine kinase inhibitor.Formula:C20H25NO5Colore e forma:SolidPeso molecolare:359.42PDZ1i
CAS:PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Formula:C28H26N8O4Colore e forma:SolidPeso molecolare:538.56Nazartinib mesylate
CAS:Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formula:C27H35ClN6O5SPurezza:98%Colore e forma:SolidPeso molecolare:591.12EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formula:C25H17ClN4O3SPeso molecolare:488.95DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formula:C32H31N5O3Purezza:99.25%Colore e forma:SolidPeso molecolare:533.62Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurezza:99.14%Colore e forma:SolidPeso molecolare:236.23SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Formula:C31H31FN8O3Colore e forma:SolidPeso molecolare:582.63EGFR/HER2-IN-9
CAS:EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFormula:C25H25ClFN5O4Colore e forma:SolidPeso molecolare:513.95Epertinib
CAS:<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formula:C30H27ClFN5O3Purezza:98%Colore e forma:SolidPeso molecolare:560.02RTC-5
CAS:RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formula:C24H22ClF3N2O3SPurezza:98.14%Colore e forma:SolidPeso molecolare:510.96Ref: TM-T12777
2mg35,00€5mg52,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€1mL*10mM (DMSO)55,00€HKI-357 dimaleate
CAS:HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formula:C39H37ClFN5O11Colore e forma:SolidPeso molecolare:806.2SDZ281-977
CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formula:C18H20O5Purezza:99.64%Colore e forma:SolidPeso molecolare:316.35MTX-531
CAS:MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Formula:C22H20ClN5O2SColore e forma:SoildPeso molecolare:453.94MS 39
CAS:MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Formula:C55H71ClFN9O7SColore e forma:SolidPeso molecolare:1056.72EGFR-IN-2
CAS:EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formula:C26H33N9O3SPurezza:98.52% - 99.79%Colore e forma:SolidPeso molecolare:551.66EGFR/C797S-IN-1
CAS:EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Formula:C28H30N4O3Colore e forma:SolidPeso molecolare:470.56EGFR T790M/L858R-IN-5
CAS:EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formula:C28H31N9OPeso molecolare:509.61Nimotuzumab
CAS:Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Purezza:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidGefitinib N-oxide
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formula:C22H24ClFN4O4Purezza:98%Colore e forma:SolidPeso molecolare:462.9BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formula:C23H27N7OColore e forma:SolidPeso molecolare:417.51PD 174265
CAS:PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formula:C17H15BrN4OPurezza:99.51%Colore e forma:SolidPeso molecolare:371.23Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formula:C18H19ClFN7Purezza:98.816%Colore e forma:SolidPeso molecolare:387.84Ref: TM-TQ0271
2mg42,00€5mg64,00€10mg101,00€25mg192,00€50mg335,00€100mg462,00€200mg645,00€1mL*10mM (DMSO)64,00€EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formula:C29H24N4O3Purezza:99.8%Colore e forma:SolidPeso molecolare:476.53Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formula:C27H30N6O3Purezza:99.26% - 99.98%Colore e forma:SolidPeso molecolare:486.57Ref: TM-T36644
1mg64,00€5mg137,00€10mg187,00€25mg344,00€50mg492,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)44,00€Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formula:C28H32N6O6Purezza:98.02% - 99.79%Colore e forma:SolidPeso molecolare:548.59Ref: TM-T35914
1mg75,00€2mg97,00€5mg170,00€10mg271,00€25mg449,00€50mg615,00€100mg843,00€500mg1.691,00€Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formula:C10H6N2O3Purezza:98.98%Colore e forma:Yellow Green Powder /Off-White SolidPeso molecolare:202.17EMI1
CAS:<p>EMI1 targets mutated EGFR in drug-resistant NSCLC research.</p>Formula:C20H18N2O3Purezza:99.96%Colore e forma:SolidPeso molecolare:334.37Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formula:C40H38ClNO5Purezza:99.97%Colore e forma:SolidPeso molecolare:648.19LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formula:C16H16ClN3O2Purezza:99.95%Colore e forma:SolidPeso molecolare:317.77PKI-166
CAS:PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formula:C20H18N4OPurezza:99.2%Colore e forma:SolidPeso molecolare:330.38Ref: TM-T16549
2mg42,00€5mg80,00€10mg117,00€25mg226,00€50mg378,00€100mg605,00€200mg810,00€1mL*10mM (DMSO)88,00€EGFR-IN-99
CAS:EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Formula:C25H22FN7O3Purezza:97.75%Colore e forma:SolidPeso molecolare:487.49A-935142
CAS:A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formula:C18H19F3N2O2Purezza:98.97% - 99.91%Colore e forma:SolidPeso molecolare:352.35Rocbrutinib
CAS:Rocbrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits antineoplastic properties [1].Formula:C42H51N9O5Colore e forma:SolidPeso molecolare:761.91EGFR-IN-32
CAS:EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.642′-Thioadenosine
CAS:2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormula:C10H13N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:283.31DZD1516
CAS:DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormula:C28H27F2N7O3Purezza:98%Colore e forma:SolidPeso molecolare:547.56JGK-068S
CAS:Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formula:C22H23BrFN5O2Purezza:98%Colore e forma:SolidPeso molecolare:488.35EGFR-IN-61
CAS:EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formula:C33H37ClN8O3Purezza:98%Colore e forma:SolidPeso molecolare:629.15EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFormula:C26H30N8O2Purezza:98%Colore e forma:SolidPeso molecolare:486.57EGFR-IN-1
CAS:<p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>Formula:C28H30N6O4Purezza:98%Colore e forma:SolidPeso molecolare:514.58EGFR/HER2-IN-13
CAS:EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.Formula:C27H36N8O3Peso molecolare:520.63EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFormula:C54H54Cl2FN7O7S2Purezza:98%Colore e forma:SolidPeso molecolare:1067.08
