EGFR
Gli inibitori del recettore del fattore di crescita epidermico (EGFR) sono composti che bloccano la segnalazione dell'EGFR, un recettore spesso sovraespresso in vari tipi di cancro e che svolge un ruolo cruciale nell'angiogenesi. Gli inibitori dell'EGFR sono utilizzati per prevenire la crescita tumorale e le metastasi interrompendo le vie che promuovono la formazione di vasi sanguigni nei tumori. Questi inibitori sono ampiamente utilizzati nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta selezione di inibitori dell'EGFR di alta qualità per supportare la tua ricerca in oncologia e angiogenesi.
Trovati 593 prodotti di "EGFR"
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TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formula:C26H25ClF3N5O3Purezza:99.73%Colore e forma:SolidPeso molecolare:547.96Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formula:C22H22ClN3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:427.88Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formula:C19H18BrClN6OPurezza:97.03%Colore e forma:SolidPeso molecolare:461.74EGFR-IN-39
CAS:EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Formula:C24H25ClN6O3Colore e forma:SolidPeso molecolare:480.95Tyrphostin 51
CAS:Tyrphostin 51 is an effective inhibitor of EGFR kinase.Formula:C13H8N4O3Purezza:98%Colore e forma:SolidPeso molecolare:268.23BIBX 1382 Dihydrochloride
CAS:BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formula:C18H21Cl3FN7Colore e forma:SolidPeso molecolare:460.76EGFR-IN-69
CAS:EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formula:C31H37Cl2N7O3SColore e forma:SolidPeso molecolare:658.64EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formula:C18H17N3SColore e forma:SolidPeso molecolare:307.41EMI48
CAS:EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formula:C21H20N2O3Colore e forma:SolidPeso molecolare:348.4EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formula:C17H14N4O4S3Colore e forma:SolidPeso molecolare:434.51EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formula:C36H44BrN10O2PColore e forma:SolidPeso molecolare:759.68SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Formula:C31H31FN8O3Colore e forma:SolidPeso molecolare:582.63EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formula:C25H17ClN4O3SPeso molecolare:488.95EGFR mutant-IN-2
CAS:EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Formula:C27H27F3N6O2SColore e forma:SolidPeso molecolare:556.6EGFR-IN-5
CAS:<p>EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>Formula:C31H38FN9OPurezza:98.17%Colore e forma:SolidPeso molecolare:571.69EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formula:C19H17ClFN3O4Purezza:98%Colore e forma:SolidPeso molecolare:405.81Antiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formula:C27H27N7O5Purezza:98%Colore e forma:SolidPeso molecolare:529.55EGFR-IN-89
CAS:EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormula:C26H31FN8O2SPurezza:98%Colore e forma:SolidPeso molecolare:538.64EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formula:C16H12Cl2N4O2Colore e forma:SolidPeso molecolare:363.2EGFR/HER2-IN-3
CAS:EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Formula:C26H23N5O3Colore e forma:SolidPeso molecolare:453.49
