BTK
Gli inibitori della tirosina chinasi di Bruton (BTK) sono composti che mirano specificamente a inibire la BTK, un enzima cruciale coinvolto nella segnalazione del recettore delle cellule B e nella regolazione dell'angiogenesi. La BTK svolge un ruolo significativo nella proliferazione e nella sopravvivenza delle cellule cancerose, in particolare nelle malignità ematologiche. Inibendo la BTK, questi composti possono interrompere l'angiogenesi e la crescita tumorale, rendendoli preziosi nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori della BTK di alta qualità per supportare la tua ricerca in oncologia, immunologia e angiogenesi.
Trovati 162 prodotti di "BTK"
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MT-802
CAS:MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).Formula:C41H41N9O8Purezza:95.93% - 97%Colore e forma:SolidPeso molecolare:787.82Ref: TM-T16157
1mg96,00€5mg187,00€10mg284,00€25mg538,00€50mg730,00€100mg938,00€200mg1.320,00€1mL*10mM (DMSO)245,00€Tirabrutinib hydrochloride
CAS:Tirabrutinib hydrochloride is a potent, highly selective, irreversible oral BTK inhibitor.Cost-effective and quality-assured.Formula:C25H23ClN6O3Purezza:99.27% - 99.95%Colore e forma:SolidPeso molecolare:490.94Orelabrutinib
CAS:<p>Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).</p>Formula:C26H25N3O3Purezza:97.77% - 99.54%Colore e forma:SolidPeso molecolare:427.49Rilzabrutinib
CAS:Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Formula:C36H40FN9O3Purezza:98.28% - 99.76%Colore e forma:SolidPeso molecolare:665.76Ref: TM-T12542
1mg99,00€5mg235,00€10mg376,00€25mg655,00€50mg944,00€100mg1.320,00€500mg2.642,00€1mL*10mM (DMSO)344,00€ARQ 531
CAS:<p>ARQ-531: potent oral BTK inhibitor, anti-cancer potential, IC50 of 0.85/0.39 nM for WT/C481S-BTK.</p>Formula:C25H23ClN4O4Purezza:98.68% - 99.63%Colore e forma:SolidPeso molecolare:478.93IBT6A
CAS:<p>IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Formula:C22H22N6OPurezza:99.8% - 99.88%Colore e forma:SolidPeso molecolare:386.45Btk inhibitor 2
CAS:Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.Formula:C24H25N5O3Purezza:99.94%Colore e forma:SolidPeso molecolare:431.49Ref: TM-T10629
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg227,00€50mg376,00€100mg457,00€1mL*10mM (DMSO)87,00€AS-1763
CAS:AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.Formula:C33H31FN6O3Purezza:≥95%Colore e forma:SolidPeso molecolare:578.64TLT8
TLT8 is a ByeTAC protein degrader that targets BTK. It induces BTK degradation by non-covalently binding to Rpn-13 and BTK. TLT8 is applicable in research on chronic lymphocytic leukemia.Colore e forma:Odour SolidPROTAC BTK Degrader-5
PROTAC BTK Degraders-5 (Compound 3e) is a selective Bruton's tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity byFormula:C52H57ClFN9O6Purezza:98%Colore e forma:SolidPeso molecolare:958.52FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidDD 03-171
CAS:<p>Potent BTK Degrader, IC50=5.1nM, CRBN-dependent, suppresses MCL; degrades Ibrutinib-resistant BTK, no kinases binding, reduces tumors in models.</p>Formula:C55H62N10O8Colore e forma:SolidPeso molecolare:991.163Acalabrutinib enantiomer
CAS:<p>R-Acalabrutinib, a BTK inhibitor,enantiomer, is researched for cancer, autoimmune diseases, and inflammation.</p>Formula:C26H23N7O2Purezza:97.27%Colore e forma:SolidPeso molecolare:465.51PROTAC BTK Degrader-13
<p>PROTAC BTK Degrader-13 (Compound 25) is a targeted BTK PROTAC degrader with a DC50 of 0.27 μM. It inhibits BTK activity with an IC50 of 0.44 μM and suppresses IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. This compound also inhibits the p38 MAPK signaling pathway, thereby blocking the activation of the BCR (B cell receptor) signaling pathway. [Pink: ligand for target protein BTK ligand 15; Black: linker; Blue: ligand for E3 ligase cereblon]</p>Formula:C33H30N6O7Colore e forma:SolidPeso molecolare:622.63Ibrutinib-biotin
CAS:<p>Ibrutinib-biotin probe links Ibrutinib to biotin, with IC50 0.755-1.02 nM for BTK (patent WO2014059368A1).</p>Formula:C56H80N12O9SPurezza:98%Colore e forma:SolidPeso molecolare:1097.39BTK-IN-40
CAS:BTK-IN-40 (compound 375) is an inhibitor of BTK.Formula:C20H25N7O2Colore e forma:SolidPeso molecolare:395.46PTD10
CAS:PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM.Formula:C49H51N11O8Purezza:99.12%Colore e forma:SolidPeso molecolare:922Ref: TM-T79201
1mgPrezzo su richiesta5mg540,00€10mgPrezzo su richiesta25mgPrezzo su richiesta50mg1.730,00€100mgPrezzo su richiestaPROTAC BTK Degrader-6
CAS:<p>PROTAC BTK Degrader-6 (Compound 15), with a DC50 of 3.18 nM, exhibits anti-inflammatory properties by inhibiting NF-κB activation and suppressing the expression</p>Formula:C45H47N11O6Purezza:98%Colore e forma:SolidPeso molecolare:837.92BCPyr
CAS:BCPyr is a new candidate BTK degrader ( DC 50 = 800 nM).Formula:C58H65F2N11O8Colore e forma:SolidPeso molecolare:1082.224I-As-1
I-As-1 is a potent inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 2.35 nM. It exhibits antiproliferative activity against Ramos cells and OCI-LY10 cells, with IC50 values of 0.52 μM and 0.11 μM, respectively.Formula:C26H27AsN6O2S2Peso molecolare:594.08529BTK inhibitor 17
CAS:BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.Formula:C25H24N6O3Purezza:99.57% - 99.88%Colore e forma:SolidPeso molecolare:456.5Ref: TM-T9706
1mg94,00€5mg170,00€10mg264,00€25mg424,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)170,00€PROTAC BTK Degrader-8
PROTACBTK Degrader-8 (compound 3) is an efficient PROTAC BTK degrader with a linker that can couple with ADC antibodies to form PAC.Formula:C80H94F2N14O20P2Peso molecolare:1670.62121Ibrutinib dimer
CAS:Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM).Formula:C50H48N12O4Purezza:98%Colore e forma:SolidPeso molecolare:880.99PROTAC BTK Degrader-11
CAS:PROTAC BTK Degrader-11 is a PROTAC degrader that targets and degrades BTK with a DC50 of 1.7 nM. It is utilized in oncological research.Formula:C48H55N11O4Colore e forma:SolidPeso molecolare:850.02GBD-9
CAS:GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN).Formula:C44H47N9O6Purezza:98%Colore e forma:SolidPeso molecolare:797.9BTK-IN-5
CAS:<p>BTK-IN-5 is a covalent inhibitor of Bruton's tyrosine kinase (BTK) designed for the treatment of medical conditions including cardiovascular diseases,</p>Formula:C23H32N4O5Colore e forma:SolidPeso molecolare:444.532PROTAC BTK Degrader-2
CAS:PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].Formula:C47H54F2N8O13Colore e forma:SolidPeso molecolare:976.97PROTAC BTK Degrader-10
CAS:PROTAC BTK Degrader-10 (Example 1P) is a PROTAC compound that targets BTK for degradation. It is applicable in the research of chronic lymphocytic leukemia (CLL). [Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon].Formula:C42H49N11O4Colore e forma:SolidPeso molecolare:771.91PROTAC BTK Degrader-1
CAS:<p>Potent, selective oral PROTAC BTK Degrader-1; IC50: 34.51 nM (WT), 64.56 nM (BTK-481S); reduces BTK protein, inhibits tumors.</p>Formula:C43H43N9O4Colore e forma:SolidPeso molecolare:749.86QL-X-138 HCl
QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.Formula:C25H20ClN5O2Purezza:99.25%Colore e forma:SoildPeso molecolare:457.91CNX-500
CAS:CNX-500: covalent Btk inhibitor linked to biotin, IC50 0.5 nM, low effect on EGFR and Src kinases.Formula:C48H68N10O9SPurezza:98%Colore e forma:SolidPeso molecolare:961.18SJF620 hydrochloride
CAS:SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].Formula:C41H45ClN8O7Purezza:98%Colore e forma:SolidPeso molecolare:797.3BIIB091
CAS:BIIB091 is a highly selective, reversible BTK inhibitor for treating autoimmune diseases.Formula:C28H34N10O2Colore e forma:SolidPeso molecolare:542.648FDU73
<p>FDU73 is a potent and selective BTK PROTAC degrader with a DC50 of 2.9 nM in JeKo-1 cells. It inhibits tumor cell proliferation and exhibits antitumor activity.</p>Colore e forma:Odour SolidTyrosinase-IN-16
CAS:Tyrosinase-IN-16 inhibited tyrosinase.Formula:C8H6BrN3SPurezza:99.94%Colore e forma:SolidPeso molecolare:256.12NRX-0492
CAS:NRX-0492: orally active BTK degrader, induces ubiquitylation/proteasomal breakdown, potent with DC50 ≤0.2 nM, DC90 ≤0.5 nM, disrupts BCR signaling.Formula:C43H51N11O6Colore e forma:SolidPeso molecolare:817.94BRK inhibitor P21d hydrochloride
CAS:BRK inhibitor P21d HCl targets breast tumor kinase with 30 nM IC50, suppresses p-SAM68 at 52 nM, useful for in vivo breast cancer research.Formula:C23H23ClFN7O2Colore e forma:SolidPeso molecolare:483.93BTK ligand-14
BTKligand-14 is a PROTAC-targeting ligand for BTK, suitable for the synthesis of FDU73.Colore e forma:Odour Solidevobrutinib
CAS:Evobrutinib(M2951) , also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK), which is important in theFormula:C25H27N5O2Purezza:98.03% - 99.58%Colore e forma:SolidPeso molecolare:429.51Ref: TM-T4387
1mg42,00€5mg88,00€10mg127,00€25mg227,00€50mg329,00€100mg472,00€500mg1.017,00€1mL*10mM (DMSO)87,00€DBt-10
DBt-10 is a potent Bruton's tyrosine kinase (BTK) degrader [1].Formula:C68H86ClFN16O6Purezza:98%Colore e forma:SolidPeso molecolare:1277.96BTK inhibitor 19
CAS:BTK inhibitor 19 is a highly selective, covalent BTK inhibitor ( IC 50 = 2.7 nM).Formula:C25H24F3N7O3Colore e forma:SolidPeso molecolare:527.508PROTAC BTK Degrader-12
CAS:<p>PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader, featuring a structure where the BTK ligand and linker are highlighted in pink and black, the linker in black, and the VHL ligand in blue.</p>Formula:C47H54N12O4Colore e forma:SolidPeso molecolare:851.01PCI-33380
CAS:PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.Formula:C46H52BF2N11O3Purezza:98%Colore e forma:SolidPeso molecolare:855.8L18I
L18I is a PROTAC (Proteolysis Targeting Chimera) that targets Btk to mitigate inflammation in autoimmune diseases. The components of L18I include the PROTAC target protein ligand IBT6A, the PROTAC linker Propargyl-PEG3-alcohol, and the E3 ubiquitin ligase ligand Lenalidomide-Br. Notably, the active control for the target protein ligand is IBT6A-CO-ethyne, while the conjugate of the E3 ubiquitin ligase ligand with the linker is Lenalidomide-C3-PEG3-N3.Formula:C47H51N11O8Colore e forma:SolidPeso molecolare:897.98PROTAC BTK Degrader-9
PROTACBTK Degrader-9 (compound 23) is a potent PROTACs degrader that specifically targets BTK. It effectively downregulates the RANKL-activated BTK-PLCγ2-Ca2+-NFATc1 signaling pathway. Consequently, PROTACBTK Degrader-9 inhibits osteoclastogenesis and reduces alveolar bone resorption in a mouse model of periodontitis.Formula:C46H52FN13O5Peso molecolare:885.41984Anti-BTK Antibody (3G585)
Anti-BTK Antibody (3G585) is an antibody targeting BTK. Anti-BTK Antibody (3G585) can be used in ELISA, IHC.Colore e forma:Odour LiquidPoseltinib
CAS:Poseltinib is an oral, irreversible BTK inhibitor (IC50 1.95 nM) with higher selectivity over BMX, TEC, and TXK, blocking BCR, FcR, and TLR signaling.Formula:C26H26N6O3Purezza:99.98%Colore e forma:SolidPeso molecolare:470.52Ref: TM-T4413
2mg35,00€5mg52,00€10mg80,00€25mg155,00€50mg274,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)49,00€IBT6A hydrochloride
CAS:IBT6A hydrochloride: Ibrutinib impurity, Btk inhibitor IC50: 0.5 nM, used in dimer/adduct synthesis.Formula:C22H23ClN6OColore e forma:SolidPeso molecolare:422.91Elsubrutinib
CAS:Elsubrutinib (ABBV-105) is an orally active, selective, and irreversible BTK inhibitor with an IC50 of 0.18 μM for the catalytic domain of BTK.Formula:C17H19N3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:297.36Ref: TM-T39130
1mg154,00€5mgPrezzo su richiesta10mg359,00€25mg605,00€50mg929,00€100mg1.388,00€1mL*10mM (DMSO)376,00€GDC-0834
CAS:GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse andFormula:C33H36N6O3SColore e forma:SolidPeso molecolare:596.74
