BTK
Gli inibitori della tirosina chinasi di Bruton (BTK) sono composti che mirano specificamente a inibire la BTK, un enzima cruciale coinvolto nella segnalazione del recettore delle cellule B e nella regolazione dell'angiogenesi. La BTK svolge un ruolo significativo nella proliferazione e nella sopravvivenza delle cellule cancerose, in particolare nelle malignità ematologiche. Inibendo la BTK, questi composti possono interrompere l'angiogenesi e la crescita tumorale, rendendoli preziosi nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori della BTK di alta qualità per supportare la tua ricerca in oncologia, immunologia e angiogenesi.
Trovati 159 prodotti di "BTK"
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IBT6A hydrochloride
CAS:IBT6A hydrochloride: Ibrutinib impurity, Btk inhibitor IC50: 0.5 nM, used in dimer/adduct synthesis.Formula:C22H23ClN6OColore e forma:SolidPeso molecolare:422.91Zanubrutinib-d5
Zanubrutinib-d5 (BGB-3111-d5) is a deuterium-labeled Zanubrutinib, an orally available Bruton's tyrosine kinase inhibitor for the study of B-cell malignancies.Formula:C27H29N5O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:476.58CNX-774
CAS:CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).Formula:C26H22FN7O3Purezza:97.35% - 99.11%Colore e forma:SolidPeso molecolare:499.5CHMFL-BMX-078
CAS:CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.Formula:C33H35N7O6Purezza:>99.99%Colore e forma:SolidPeso molecolare:625.67Larotinib mesylate hydrate
CAS:Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nMFormula:C26H36ClFN4O11S2Colore e forma:SolidPeso molecolare:699.17BIIB068
CAS:BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.Formula:C23H29N7O2Purezza:97.98%Colore e forma:SolidPeso molecolare:435.52PCI 29732
CAS:PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.Formula:C22H21N5OPurezza:99.81%Colore e forma:SolidPeso molecolare:371.43Ibrutinib deacryloylpiperidine
CAS:Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.Formula:C17H13N5OPurezza:99.47%Colore e forma:SolidPeso molecolare:303.32Fenebrutinib
CAS:<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>Formula:C37H44N8O4Purezza:98.26% - 98.94%Colore e forma:SolidPeso molecolare:664.8Tolebrutinib
CAS:<p>Tolebrutinib is an oral, selective BTK inhibitor, effective for MS research, with brain penetration and IC50s of 0.4/0.7 nM in cells.</p>Formula:C26H25N5O3Purezza:98.4% - 98.82%Colore e forma:SolidPeso molecolare:455.51BTK IN-1
CAS:<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Formula:C19H21ClN6OPurezza:97.38%Colore e forma:SolidPeso molecolare:384.86Branebrutinib
CAS:<p>Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.</p>Formula:C20H23FN4O2Purezza:95.86% - 99.31%Colore e forma:SolidPeso molecolare:370.42Acalabrutinib
CAS:Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formula:C26H23N7O2Purezza:98.94% - 99.64%Colore e forma:SolidPeso molecolare:465.51zanubrutinib
CAS:Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).Formula:C27H29N5O3Purezza:98.42% - 99.76%Colore e forma:SolidPeso molecolare:471.55Ibrutinib
CAS:Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.Formula:C25H24N6O2Purezza:98% - 99.93%Colore e forma:SolidPeso molecolare:440.5Remibrutinib
CAS:<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Formula:C27H27F2N5O3Purezza:99.5% - 99.81%Colore e forma:SolidPeso molecolare:507.53(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formula:C29H35ClFN7O3Purezza:99.64%Colore e forma:SolidPeso molecolare:584.08Avitinib
CAS:Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formula:C26H26FN7O2Purezza:99.81% - >99.99%Colore e forma:SolidPeso molecolare:487.53RN486
CAS:<p>RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).</p>Formula:C35H35FN6O3Purezza:99.38%Colore e forma:SolidPeso molecolare:606.69Spebrutinib
CAS:Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplasticFormula:C22H22FN5O3Purezza:97.02% - >99.99%Colore e forma:SolidPeso molecolare:423.44Olmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formula:C26H26N6O2SPurezza:99.14% - 99.63%Colore e forma:SolidPeso molecolare:486.59BMS-986142
CAS:BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).Formula:C32H30F2N4O4Purezza:99.44% - 99.76%Colore e forma:SolidPeso molecolare:572.6Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purezza:99.22%Colore e forma:SolidPeso molecolare:561.03CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purezza:97.69% - 97.88%Colore e forma:SolidPeso molecolare:579.69TL-895
CAS:TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).Formula:C25H26FN5O2Purezza:99.96%Colore e forma:SolidPeso molecolare:447.5(Rac)-IBT6A
CAS:(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.Formula:C22H22N6OPurezza:99.24%Colore e forma:SolidPeso molecolare:386.45(Z)-LFM-A13
CAS:(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formula:C11H8Br2N2O2Purezza:99.88%Colore e forma:SolidPeso molecolare:360N-piperidine Ibrutinib
CAS:<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formula:C22H22N6OPurezza:96.65%Colore e forma:SolidPeso molecolare:386.45ONO-4059 analog
CAS:ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.Formula:C25H24N6O3Purezza:99.25%Colore e forma:SolidPeso molecolare:456.5BTK Protein, Human, Recombinant (His)
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.Purezza:90%Colore e forma:Lyophilized PowderPeso molecolare:78.3 kDa (predicted)Ibrutinib-d5
CAS:Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.Formula:C25H24N6O2Purezza:98%Colore e forma:SolidPeso molecolare:445.53CP-547632
CAS:CP-547632 is an oral ATP-competitive inhibitor of VEGFR-2/FGF kinase with IC50s of 11/9 nM, highly selective, has antitumor activity.Formula:C20H24BrF2N5O3SPurezza:99.14%Colore e forma:SolidPeso molecolare:532.4JAK3/BTK-IN-6
CAS:JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Formula:C21H17BF3N5O3Colore e forma:SolidPeso molecolare:455.2BI-1622
CAS:BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Formula:C26H24N10O2Colore e forma:SolidPeso molecolare:508.53BLK-IN-2
CAS:<p>BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。</p>Formula:C39H41N9O3Colore e forma:SolidPeso molecolare:683.8BTK-IN-23
CAS:BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.Formula:C27H28N6O2Colore e forma:SolidPeso molecolare:468.55BLK-IN-1
CAS:BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.Formula:C29H23F3N6O3Colore e forma:SolidPeso molecolare:560.53GDC-0834 Racemate
CAS:GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitorFormula:C33H36N6O3SColore e forma:SolidPeso molecolare:596.74SJF620
CAS:SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).Formula:C41H44N8O7Purezza:98%Colore e forma:SolidPeso molecolare:760.84PF-06465469
CAS:PF-06465469, a covalent ITK and BTK inhibitor (IC₅₀ = 2 nM), suppresses CXCL12-mediated migration and decreases PD-1/LAG-3 for leukemia and lymphoma research.Formula:C30H33N7O2Purezza:98%Colore e forma:SolidPeso molecolare:523.63BTK-IN-22
CAS:BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.Formula:C26H26N6O2Colore e forma:SolidPeso molecolare:454.52GDC-0834 S-enantiomer
CAS:GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK).Formula:C33H36N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:596.74JAK3/BTK-IN-5
CAS:JAK3/BTK-IN-5 is a potent dual inhibitor targeting JAK3 and BTK with synergistic effects, valuable for related autoimmune disease research.Formula:C19H22ClN7O2Colore e forma:SolidPeso molecolare:415.88VA5 TG2 inhibitor
CAS:VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.Formula:C31H34N4O8Purezza:98%Colore e forma:SolidPeso molecolare:590.62JNJ-64264681
CAS:JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formula:C27H30N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:518.63BTK inhibitor 10
CAS:BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.Formula:C25H23N5O3Purezza:98%Colore e forma:SolidPeso molecolare:441.48JS25
CAS:JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.Formula:C29H24N4O4SColore e forma:SolidPeso molecolare:524.59HZ-A-005
CAS:HZ-A-005 is a selective, potent, covalent inhibitor of Bruton's tyrosine kinase (BTK). HZ-A-005 significantly inhibits tumour growth in a xenograft mouse model.Formula:C25H23ClN6O2Colore e forma:SolidPeso molecolare:474.94(R)-Elsubrutinib
CAS:(R)-Elsubrutinib ((R)-ABBV-105) is a Btk inhibitor and an isomer of Elsubrutinib, suitable for inflammation research.Formula:C17H19N3O2Purezza:99.05%Colore e forma:SolidPeso molecolare:297.35SB-633825
CAS:SB-633825 can inhibit cancer cell growth and angiogenesis.Formula:C28H25N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:483.58
