FAK
Gli inibitori della chinasi di adesione focale (FAK) prendono di mira la FAK, una chinasi coinvolta nell'adesione cellulare, nella migrazione e nell'angiogenesi. La FAK è frequentemente sovraespressa nei tumori e contribuisce alla formazione di nuovi vasi sanguigni che forniscono nutrienti al tumore. L'inibizione della FAK può interrompere questi processi, rendendo gli inibitori della FAK strumenti preziosi nella terapia del cancro e nella ricerca sull'angiogenesi. Presso CymitQuimica, offriamo una gamma completa di inibitori della FAK di alta qualità per supportare la tua ricerca in biologia cellulare, cancro e angiogenesi.
Trovati 72 prodotti di "FAK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
FAK inhibitor 2
CAS:FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .Formula:C29H33F3N8O2S2Colore e forma:SolidPeso molecolare:646.75FAK-IN-8
CAS:FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].Formula:C15H9Cl2N3O2SColore e forma:SolidPeso molecolare:366.22FAK inhibitor 5
CAS:FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.Formula:C20H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:367.46ProMMP-9 inhibitor-3c
CAS:ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.Formula:C18H20FN3O2SColore e forma:SolidPeso molecolare:361.43Adhesamine
CAS:Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Formula:C24H32Cl4N8O2S2Colore e forma:SolidPeso molecolare:670.51FLT3-IN-17
CAS:FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.Formula:C23H24N6O2S2Colore e forma:SolidPeso molecolare:480.61TG53
CAS:TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.Formula:C21H22ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:411.88NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formula:C8H15Cl4N4ORuSPurezza:98%Colore e forma:SolidPeso molecolare:458.18Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formula:C20H22ClF3N8O3SPurezza:98.06% - 98.78%Colore e forma:SolidPeso molecolare:546.95Roslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formula:C13H19BrN4Purezza:99.34%Colore e forma:SolidPeso molecolare:311.22FC 11
CAS:FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Formula:C41H42F3N13O9SColore e forma:SolidPeso molecolare:949.91Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formula:C28H28F4N6O4Purezza:98.84% - 99.85%Colore e forma:SolidPeso molecolare:588.55FAK-IN-6
FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.Formula:C25H31ClN5O6PSColore e forma:SolidPeso molecolare:596.04FAK-IN-26
CAS:<p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>Formula:C20H19BrFN5O2Colore e forma:SolidPeso molecolare:460.30Pyk2-IN-2
CAS:Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].Formula:C27H27N7OColore e forma:SolidPeso molecolare:465.55FAK-IN-21
CAS:FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Formula:C22H22F2N8O3SColore e forma:SolidPeso molecolare:516.52JP-153
CAS:JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.Formula:C21H19NO5Colore e forma:SolidPeso molecolare:365.379OXA-11
CAS:OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Formula:C37H49F3N7O5PPurezza:98.70% - 99.20%Colore e forma:SolidPeso molecolare:759.8FAK-IN-23
CAS:<p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>Formula:C32H38F3N5O8Colore e forma:SolidPeso molecolare:677.668Ifebemtinib tosylate
CAS:Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.Formula:C35H36F4N6O7SColore e forma:SolidPeso molecolare:760.76FAK inhibitor 6
CAS:Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.Formula:C25H24FN5O2SColore e forma:SolidPeso molecolare:477.55FAK-IN-3
<p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>Formula:C28H28N6O4Colore e forma:SolidPeso molecolare:512.56
