FAK
Gli inibitori della chinasi di adesione focale (FAK) prendono di mira la FAK, una chinasi coinvolta nell'adesione cellulare, nella migrazione e nell'angiogenesi. La FAK è frequentemente sovraespressa nei tumori e contribuisce alla formazione di nuovi vasi sanguigni che forniscono nutrienti al tumore. L'inibizione della FAK può interrompere questi processi, rendendo gli inibitori della FAK strumenti preziosi nella terapia del cancro e nella ricerca sull'angiogenesi. Presso CymitQuimica, offriamo una gamma completa di inibitori della FAK di alta qualità per supportare la tua ricerca in biologia cellulare, cancro e angiogenesi.
Trovati 72 prodotti di "FAK"
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GSK2256098
CAS:<p>GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.</p>Formula:C20H23ClN6O2Purezza:99.46% - 99.74%Colore e forma:SolidPeso molecolare:414.89NVP-TAE 226
CAS:<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Formula:C23H25ClN6O3Purezza:98.07% - 98.78%Colore e forma:SolidPeso molecolare:468.94PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formula:C21H20F3N7O3S·C6H6O3SPurezza:97.65% - 99.01%Colore e forma:SolidPeso molecolare:665.66PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Formula:C25H26F3N5O3Purezza:99.14% - 99.75%Colore e forma:SolidPeso molecolare:501.5CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purezza:98.86% - 99.98%Colore e forma:SolidPeso molecolare:580.12PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Formula:C21H20F3N7O3SPurezza:97.17% - >99.99%Colore e forma:SolidPeso molecolare:507.49FAK activator 1
CAS:<p>ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.</p>Formula:C23H26F3N3O3Purezza:99.19%Colore e forma:SoildPeso molecolare:449.47PF-719 free base
CAS:PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.Formula:C22H27F3N6OColore e forma:SolidPeso molecolare:448.48PH11
CAS:PH11, a FAK inhibitor, reactivates TRAIL apoptosis in PANC-1 cells by reducing c-FLIP and inhibiting FAK/PI3K/AKT.Formula:C22H22N6O5Colore e forma:SolidPeso molecolare:450.45Y 11
CAS:focal adhesion kinase (FAK) inhibitorFormula:C8H17BrN4OPurezza:98%Colore e forma:SolidPeso molecolare:265.15FAK inhibitor 2
CAS:FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .Formula:C29H33F3N8O2S2Colore e forma:SolidPeso molecolare:646.75FAK-IN-8
CAS:<p>FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].</p>Formula:C15H9Cl2N3O2SColore e forma:SolidPeso molecolare:366.22FAK inhibitor 5
CAS:FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.Formula:C20H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:367.46ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Formula:C18H20FN3O2SColore e forma:SolidPeso molecolare:361.43Adhesamine
CAS:Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Formula:C24H32Cl4N8O2S2Colore e forma:SolidPeso molecolare:670.51FLT3-IN-17
CAS:FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.Formula:C23H24N6O2S2Colore e forma:SolidPeso molecolare:480.61TG53
CAS:TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.Formula:C21H22ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:411.88NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formula:C8H15Cl4N4ORuSPurezza:98%Colore e forma:SolidPeso molecolare:458.18Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formula:C20H22ClF3N8O3SPurezza:98.06% - 98.78%Colore e forma:SolidPeso molecolare:546.95Roslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formula:C13H19BrN4Purezza:99.34%Colore e forma:SolidPeso molecolare:311.22
