ASK
Gli inibitori della chinasi regolatrice dell'apoptosi (ASK) prendono di mira la famiglia di chinasi ASK, che sono regolatori critici dell'apoptosi e delle vie di risposta allo stress. Le chinasi ASK sono coinvolte nell'attivazione dell'apoptosi in risposta a vari segnali di stress, tra cui lo stress ossidativo e i danni al DNA. Inibendo ASK, questi composti possono modulare la segnalazione apoptotica, fornendo strumenti preziosi per la ricerca sulla morte cellulare, il cancro e le malattie neurodegenerative. Presso CymitQuimica, offriamo una gamma di inibitori ASK di alta qualità per supportare la tua ricerca in apoptosi, segnalazione cellulare e meccanismi delle malattie.
Trovati 13 prodotti per "ASK".
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dASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Colore e forma:Odour SolidASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. It effectively suppresses the activation of the ASK1-p38/JNK pathway induced by TNF-α. Additionally, ASK1-IN-12 reduces cholesterol elevation and lipid droplet accumulation induced by free fatty acids, improving hepatic steatosis. This compound is valuable for research on non-alcoholic steatohepatitis (NASH).dASK1
CAS:dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.Formula:C38H38F2N10O8Colore e forma:SolidPeso molecolare:800.77Anti-DBF4 Antibody (2Q22)
Anti-DBF4 Antibody (2Q22) is an antibody targeting DBF4. Anti-DBF4 Antibody (2Q22) can be used in ELISA, WB, IF Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200.Colore e forma:Odour LiquidASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purezza:99.92%Colore e forma:White SolidPeso molecolare:405.41MSC 2032964A
CAS:MSC 2032964A: Potent, selective ASK1 inhibitor, IC50=93 nM, oral, brain-permeable, curbs neuroinflammation, blocks LPS-induced ASK1/p38 activation.Formula:C16H13F3N6OPurezza:99.76%Colore e forma:SolidPeso molecolare:362.31Ref: TM-T33514
1mg79,00€2mg92,00€5mg149,00€1mL*10mM (DMSO)168,00€10mg227,00€25mg371,00€50mg530,00€100mg713,00€200mg982,00€ASK1 ligand 1
CAS:ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Formula:C17H16F2N6OColore e forma:SolidPeso molecolare:358.35ASK1-IN-8
CAS:ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.Formula:C26H32N8O2Colore e forma:SolidPeso molecolare:488.585CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formula:C19H18N4O4S2Purezza:98%Colore e forma:SolidPeso molecolare:430.5ASK1-IN-9
CAS:ASK1-IN-9 (Compound 3) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It is applicable for inflammation research.Formula:C21H20N6O2Peso molecolare:388.43ASK1-IN-11
CAS:ASK1-IN-11 (Compound 7) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It also exhibits inhibitory activity against TNF-α, MYLK/MLCK kinase, and the hERG potassium ion channel. ASK1-IN-11 can be utilized in inflammation research.Formula:C23H22N6O3Peso molecolare:430.47ASK1-IN-10
CAS:ASK1-IN-10 (Compound 27) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of less than 200 nM. It also exhibits inhibitory activity on the hERG potassium channel. ASK1-IN-10 is utilized in inflammation research.Formula:C22H19N7OPeso molecolare:397.44ASK1-IN-7
CAS:ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formula:C13H8N2O2S2Colore e forma:SolidPeso molecolare:288.345
