TNF

GSK2593074A is a necroptosis inhibitor for dual-targeting to both RIP1 and RIP3.

Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can …

GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor ( IC50: 8.6 nM …

GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to …

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and …

Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially …

Hederacoside D is a bioactive saponins from Hedera helix.

RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability …

RIPA-56 is an inhibitor of RIP1

N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors …

Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is …

Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara …

MALTOTETRAOSE are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial …

GSK872 HCl is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain …

Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; …

Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is …

L-Epinephrine Bitartrate is alpha- and beta-adrenergic receptor stimulator.

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

GNE684 is a potent inhibitor of receptor-interacting protein 1 (RIP1; (mean Kiapps: 21 nM, 189 …

Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with …

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of …

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 …

cRIPGBM is a proapoptotic derivative of RIPGBM and a cell type-selective inducer of apoptosis in …

Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and …

Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H …

LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.

Pomalidomide inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an …

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase …

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress …

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of …

UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including …

Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.

GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance …

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, …

Dehydroeburicoic acid induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation …

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to …

1. Linalool, a natural compound of the essential oils, has been shown to have antinociceptive, …

Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway …

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, …

Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of …

TNF-α-IN-1 is an inhibitor of TNF-α.

1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced …

(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential …

1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, …

Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic …

Cepharanthine, a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation …

Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, …

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat …

Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation …

Neoisoastilbin may have antioxidant and anti-inflammatory activities.

Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, …

Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.

Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, …

Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as …

7-O-Methylmorroniside exhibits anti-inflammatory activity.

Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against …

Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and …

Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on …

25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus …

GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).