TNF
Gli inibitori del fattore di necrosi tumorale (TNF) sono composti che bloccano l'attività del TNF, una citochina coinvolta nell'infiammazione e nella regolazione dell'apoptosi. Il TNF può indurre l'apoptosi in alcuni tipi di cellule mentre promuove la sopravvivenza e l'infiammazione in altri. L'inibizione del TNF è cruciale nel trattamento delle malattie autoimmuni, delle condizioni infiammatorie croniche e di alcuni tipi di cancro. Gli inibitori del TNF aiutano a modulare la risposta immunitaria e a ridurre i danni ai tessuti causati da un'infiammazione eccessiva. Presso CymitQuimica, offriamo una vasta gamma di inibitori del TNF di alta qualità per supportare la tua ricerca in immunologia, infiammazione e apoptosi.
Trovati 92 prodotti di "TNF"
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TNF α Protein, Ferret, Recombinant (His)
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E.Colore e forma:Lyophilized PowderPeso molecolare:18.88 kDa (predicted) same as Tris-Bis PAGE result.TNF α Protein, Human, Recombinant (His & Avi)
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Colore e forma:Lyophilized PowderPeso molecolare:20.3 kDa (predicted). Due to glycosylation, the protein migrates to 21-25 kDa based on Tris-Bis PAGE result.TNF α Protein, Cynomolgus, Recombinant (His)
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag.Colore e forma:Lyophilized PowderPeso molecolare:18.35 kDa (predicted). Due to glycosylation, the protein migrates to 19-25 kDa based on Tris-Bis PAGE result.LASSBio-1135
CAS:LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Formula:C18H14N4Purezza:99.09%Colore e forma:SolidPeso molecolare:286.33R-7050
CAS:<p>R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.</p>Formula:C16H8ClF3N4SPurezza:98.64% - 99.8%Colore e forma:SolidPeso molecolare:380.77(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Formula:C16H16N6OPurezza:98.44%Colore e forma:SolidPeso molecolare:308.34Hispidol
CAS:<p>Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon</p>Formula:C15H10O4Purezza:97.86% - 98.45%Colore e forma:SolidPeso molecolare:254.24STING-IN-2
CAS:STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. STING-IN-2 can be used for autoinflammatory disease research.Formula:C15H16N2O4Purezza:98.61%Colore e forma:SolidPeso molecolare:288.3Roquinimex
CAS:Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis andFormula:C18H16N2O3Purezza:97.69%Colore e forma:SolidPeso molecolare:308.33N-Formyl-Met-Leu-Phe
CAS:N-Formyl-Met-Leu-Phe (N-Formyl-MLF) (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).Formula:C21H31N3O5SPurezza:98.69% - 98.69%Colore e forma:SolidPeso molecolare:437.55C25-140
CAS:<p>C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.</p>Formula:C26H31N7OPurezza:98.81%Colore e forma:SolidPeso molecolare:457.57Resatorvid
CAS:<p>Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.</p>Formula:C15H17ClFNO4SPurezza:99.31% - >99.99%Colore e forma:SolidPeso molecolare:361.82UTL-5g
CAS:<p>UTL-5g is a chemoprotective TNF-α inhibitor reducing cisplatin side effects and toxicity in liver, kidneys, and blood.</p>Formula:C11H8Cl2N2O2Purezza:99.83%Colore e forma:SolidPeso molecolare:271.1Tulisokibart
CAS:Tulisokibart (PRA023) is a humanized anti-TNFSF15 monoclonal antibody used to study colon cancer.Purezza:98.38% (SEC-HPLC) - > 95%Colore e forma:LiquidDalnicastobart
CAS:Dalnicastobart (LVGN-7409) is a humanized monoclonal antibody targeting CD40/TNFRSF5 with agonist activity, immunostimulatory and antitumor.Purezza:95% - 97.4% (SDS-PAGE); 97.8% (SEC-HPLC)Colore e forma:LiquidAfimkibart
CAS:Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.Purezza:95% - 99.2% (SDS-PAGE); 95.3% (SEC-HPLC)Colore e forma:SoildRavagalimab
CAS:Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.Purezza:95% - 96.9% (SDS-PAGE); 99.5% (SEC-HPLC)Colore e forma:LiquidCifurtilimab
CAS:<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Purezza:95%Colore e forma:LiquidFrexalimab
CAS:Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].Purezza:95% - 95%Colore e forma:LiquidToralizumab
CAS:Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.Colore e forma:LiquidPeso molecolare:148.43 (kD)Bleselumab
CAS:Bleselumab (ASKP 1240) is a humanised monoclonal antibody targeting CD40, inhibiting immune responses, organ transplant rejection.Purezza:95%Colore e forma:LiquidTabalumab
CAS:Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.Purezza:95%Colore e forma:LiquidIratumumab
CAS:Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.Colore e forma:LiquidLicaminlimab
<p>Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.</p>Colore e forma:Odour LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.Colore e forma:Odour LiquidTecaginlimab
CAS:Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.Colore e forma:LiquidAfelimomab
CAS:Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].Colore e forma:LiquidSelicrelumab
CAS:Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.Purezza:98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Colore e forma:LiquidVU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Formula:C25H27N5O2Purezza:99.73%Colore e forma:SolidPeso molecolare:429.51TNF-α-IN-1
CAS:TNF-α-IN-1 is a TNF-α inhibitor.Formula:C16H14ClN3O5Purezza:98.82%Colore e forma:SolidPeso molecolare:363.75Mitazalimab
CAS:Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.Purezza:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidUCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Formula:C22H21N3OPurezza:98.76%Colore e forma:SolidPeso molecolare:343.42SPD304 dihydrochloride
CAS:<p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>Formula:C32H34Cl2F3N3O2Purezza:99.25%Colore e forma:SolidPeso molecolare:620.53PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurezza:98.09% - 99.64%Colore e forma:SolidPeso molecolare:424.52C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Formula:C24H15ClN6O3SPurezza:≥98%Colore e forma:SolidPeso molecolare:502.93Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.46BMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Formula:C27H32N4O4Purezza:99.16%Colore e forma:SolidPeso molecolare:476.57Boserolimab
CAS:<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Colore e forma:LiquidCDC801
CAS:<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Formula:C23H24N2O5Purezza:99.61%Colore e forma:SolidPeso molecolare:408.45TNF-α-IN-12
CAS:TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Formula:C21H22O6Colore e forma:SolidPeso molecolare:370.4TNF-α-IN-14
CAS:TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].Formula:C22H26O6Colore e forma:SolidPeso molecolare:386.44TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Formula:C25H21ClF2N6OPurezza:99.92%Colore e forma:SolidPeso molecolare:494.92
