p53
Gli inibitori di p53 prendono di mira la proteina p53, un soppressore tumorale che svolge un ruolo cruciale nella regolazione del ciclo cellulare, nella riparazione del DNA e nell'apoptosi. Sebbene p53 sia spesso mutato o inattivato nelle cellule tumorali, la sua inibizione è talvolta necessaria per proteggere le cellule sane dall'apoptosi durante determinati trattamenti. D'altra parte, il ripristino della funzione di p53 nei tumori può portare all'apoptosi delle cellule cancerose. La ricerca sugli inibitori di p53 è complessa e significativa sia per comprendere i meccanismi del cancro sia per sviluppare nuove terapie. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di p53 di alta qualità per supportare la tua ricerca in biologia del cancro, apoptosi e sviluppo
Trovati 63 prodotti di "p53"
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MT 63-78
CAS:<p>MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).</p>Formula:C21H14N2O2Purezza:97.11%Colore e forma:SolidPeso molecolare:326.35Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formula:C29H32O13Purezza:99.19% - 99.94%Colore e forma:Crystals From Methanol SolidPeso molecolare:588.56Unesbulin
CAS:<p>Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).</p>Formula:C19H13F5N6Purezza:98.71%Colore e forma:SolidPeso molecolare:420.34Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formula:C5H15N2O3PSPurezza:99.59%Colore e forma:White SolidPeso molecolare:214.22NSC-87877
CAS:NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.Formula:C19H13N3O7S2Purezza:97.35%Colore e forma:SolidPeso molecolare:459.45Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Formula:C14H19Cl2NO2Purezza:97.37% - 98.45%Colore e forma:Off-White Slightly Granular Powder Melting Point 65-69°CPeso molecolare:304.21Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFormula:C23H30CLN3O·2HClPurezza:98.24% - 99.80%Colore e forma:Yellow Crystals Or PowderPeso molecolare:472.88Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Colore e forma:Odour SolidTetrofosmin
CAS:Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.Formula:C18H40O4P2Colore e forma:SolidPeso molecolare:382.46ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formula:C110H210N52O26Purezza:99.55%Colore e forma:SolidPeso molecolare:2677.18Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Colore e forma:Odour Solidp53 (17-26)
CAS:Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Formula:C60H90N12O17Purezza:98%Colore e forma:SolidPeso molecolare:1251.43UNC 0631
CAS:UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).Formula:C37H61N7O2Purezza:97.42%Colore e forma:SolidPeso molecolare:635.93BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Formula:C20H22ClN5OPurezza:99.62%Colore e forma:SolidPeso molecolare:383.88HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.Anti-p53 Antibody (9D896)
Anti-p53 Antibody (9D896) is an antibody targeting p53. Anti-p53 Antibody (9D896) can be used in ELISA, WB, IHC, IF.Colore e forma:Odour LiquidAnti-p53 Antibody (2H232)
Anti-p53 Antibody (2H232) is an antibody targeting p53. Anti-p53 Antibody (2H232) can be used in ELISA, IHC.Colore e forma:Odour LiquidAnti-p53 Antibody (3K688)
<p>Anti-p53 Antibody (3K688) is a Rabbit antibody targeting p53. Anti-p53 Antibody (3K688) can be used in WB,ELISA,IP.</p>Colore e forma:Odour LiquidAnti-p53 Antibody (9G129)
Anti-p53 Antibody (9G129) is a Rabbit antibody targeting p53. Anti-p53 Antibody (9G129) can be used in IHC-P,ICC/IF.Colore e forma:Odour LiquidAnti-p53 Antibody (9G324)
Anti-p53 Antibody (9G324) is an antibody targeting p53. Anti-p53 Antibody (9G324) can be used in ELISA, IF.Colore e forma:Odour LiquidAnti-Phospho-TP53 (Ser392) Antibody (7W136)
Anti-Phospho-TP53 (Ser392) Antibody (7W136) is an antibody targeting Phospho-TP53 (Ser392). Anti-Phospho-TP53 (Ser392) Antibody (7W136) can be used in ELISA, WB.Colore e forma:Odour LiquidAnti-p53 Antibody (1J151)
Anti-p53 Antibody (1J151) is a Mouse antibody targeting p53. Anti-p53 Antibody (1J151) can be used in ELISA(Cap).Colore e forma:Odour LiquidAnti-p53 Antibody (8M251)
Anti-p53 Antibody (8M251) is an antibody targeting p53. Anti-p53 Antibody (8M251) can be used in ELISA, WB, IHC, IF.Colore e forma:Odour LiquidAnti-Phospho-TP53 (Thr55) Antibody (8C690)
Anti-Phospho-TP53 (Thr55) Antibody (8C690) is an antibody targeting Phospho-TP53 (Thr55). Anti-Phospho-TP53 (Thr55) Antibody (8C690) can be used in ELISA, WB, IF.Colore e forma:Odour LiquidAnti-Phospho-TP53 (Ser33) Antibody (4K787)
Anti-Phospho-TP53 (Ser33) Antibody (4K787) is an antibody targeting Phospho-TP53 (Ser33). Anti-Phospho-TP53 (Ser33) Antibody (4K787) can be used in ELISA, IHC, IF.Colore e forma:Odour LiquidAnti-p53 Antibody (2V863)
Anti-p53 Antibody (2V863) is a Mouse antibody targeting p53. Anti-p53 Antibody (2V863) can be used in ELISA,ELISA(Det).Colore e forma:Odour LiquidAnti-Phospho-TP53 (Ser9) Antibody (4M602)
Anti-Phospho-TP53 (Ser9) Antibody (4M602) is an antibody targeting Phospho-TP53 (Ser9). Anti-Phospho-TP53 (Ser9) Antibody (4M602) can be used in ELISA, IF.Colore e forma:Odour LiquidAnti-p53 Antibody (8C308)
Anti-p53 Antibody (8C308) is an antibody targeting p53. Anti-p53 Antibody (8C308) can be used in ELISA, WB, IF, FCM.Colore e forma:Odour LiquidMethylstat
CAS:<p>Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.</p>Formula:C28H31N3O6Purezza:98.34% - 98.34%Colore e forma:SolidPeso molecolare:505.56p53 Protein, Cynomolgus, Recombinant
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family.Colore e forma:Lyophilized PowderPeso molecolare:43.7 kDa (predicted); 48 kDa (reducing conditions)HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Colore e forma:Odour Lyophilized PowderHLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Colore e forma:Lyophilized PowderPeso molecolare:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Colore e forma:Odour Lyophilized PowderProteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Formula:C20H21B2NO5Purezza:99.77%Colore e forma:SolidPeso molecolare:377.01LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:574.76KCC-07
CAS:<p>KCC-07: Selective, potent, brain-penetrant MBD2 inhibitor with anticancer effects, blocking MBD2-DNA binding and activating BAI1 signaling.</p>Formula:C14H11N3OSPurezza:98.86% - 99.01%Colore e forma:SolidPeso molecolare:269.32UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.9Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Formula:C23H28O7Purezza:99.14% - 99.95%Colore e forma:SolidPeso molecolare:416.46XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formula:C48H57ClN8O5Purezza:98.75%Colore e forma:SolidPeso molecolare:861.47BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Formula:C19H13N3O7S2·2NaPurezza:97.89%Colore e forma:SolidPeso molecolare:503.42(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purezza:99.09% - 99.81%Colore e forma:SolidPeso molecolare:364.35NSC348884
CAS:NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).Formula:C38H40N10Purezza:98.69% - 99.91%Colore e forma:SolidPeso molecolare:636.79Lumichrome
CAS:Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.Formula:C12H10N4O2Purezza:99.69% - 99.93%Colore e forma:SolidPeso molecolare:242.23XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Formula:C11H13N5O4Purezza:99.51%Colore e forma:SolidPeso molecolare:279.25cjoc42
CAS:<p>Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.</p>Formula:C20H21N3O5SPurezza:99.56%Colore e forma:SolidPeso molecolare:415.46Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurezza:99.71% - 99.80%Colore e forma:SolidPeso molecolare:268.27Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formula:C33H48O6Purezza:97.10% - 99.04%Colore e forma:White Crystalline SolidPeso molecolare:540.73BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurezza:99.41% - 99.95%Colore e forma:SolidPeso molecolare:600.02Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purezza:98.71% - 99.86%Colore e forma:SolidPeso molecolare:868.70Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purezza:95.62% - 99.71%Colore e forma:SolidPeso molecolare:581.49YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purezza:99.47%Colore e forma:SolidPeso molecolare:372.18NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Formula:C23H20N2OPurezza:96.94%Colore e forma:SolidPeso molecolare:340.42O6-Benzylguanine
CAS:O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.Formula:C12H11N5OPurezza:98.9%Colore e forma:Solid CrystallinePeso molecolare:241.25UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formula:C26H43N7O2Purezza:99.80%Colore e forma:SolidPeso molecolare:485.67NSC 146109 hydrochloride
CAS:NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.Formula:C17H17ClN2SPurezza:99.28%Colore e forma:SolidPeso molecolare:316.85UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formula:C27H45N7O3Purezza:99.80%Colore e forma:SolidPeso molecolare:515.69BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Formula:C14H16N2OSPurezza:99.84%Colore e forma:SolidPeso molecolare:260.35PDK4-IN-1 hydrochloride
CAS:PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).Formula:C22H20ClN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:393.87
