p53
Gli inibitori di p53 prendono di mira la proteina p53, un soppressore tumorale che svolge un ruolo cruciale nella regolazione del ciclo cellulare, nella riparazione del DNA e nell'apoptosi. Sebbene p53 sia spesso mutato o inattivato nelle cellule tumorali, la sua inibizione è talvolta necessaria per proteggere le cellule sane dall'apoptosi durante determinati trattamenti. D'altra parte, il ripristino della funzione di p53 nei tumori può portare all'apoptosi delle cellule cancerose. La ricerca sugli inibitori di p53 è complessa e significativa sia per comprendere i meccanismi del cancro sia per sviluppare nuove terapie. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di p53 di alta qualità per supportare la tua ricerca in biologia del cancro, apoptosi e sviluppo
Trovati 63 prodotti di "p53"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.9Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Formula:C23H28O7Purezza:99.14% - 99.95%Colore e forma:SolidPeso molecolare:416.46XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formula:C48H57ClN8O5Purezza:98.75%Colore e forma:SolidPeso molecolare:861.47BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Formula:C19H13N3O7S2·2NaPurezza:97.89%Colore e forma:SolidPeso molecolare:503.42(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purezza:99.09% - 99.81%Colore e forma:SolidPeso molecolare:364.35NSC348884
CAS:NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).Formula:C38H40N10Purezza:98.69% - 99.91%Colore e forma:SolidPeso molecolare:636.79Lumichrome
CAS:Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.Formula:C12H10N4O2Purezza:99.69% - 99.93%Colore e forma:SolidPeso molecolare:242.23XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Formula:C11H13N5O4Purezza:99.51%Colore e forma:SolidPeso molecolare:279.25cjoc42
CAS:<p>Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.</p>Formula:C20H21N3O5SPurezza:99.56%Colore e forma:SolidPeso molecolare:415.46Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurezza:99.71% - 99.80%Colore e forma:SolidPeso molecolare:268.27Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formula:C33H48O6Purezza:97.10% - 99.04%Colore e forma:White Crystalline SolidPeso molecolare:540.73BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurezza:99.41% - 99.95%Colore e forma:SolidPeso molecolare:600.02Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purezza:98.71% - 99.86%Colore e forma:SolidPeso molecolare:868.70Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purezza:95.62% - 99.71%Colore e forma:SolidPeso molecolare:581.49YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purezza:99.47%Colore e forma:SolidPeso molecolare:372.18NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Formula:C23H20N2OPurezza:96.94%Colore e forma:SolidPeso molecolare:340.42O6-Benzylguanine
CAS:O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.Formula:C12H11N5OPurezza:98.9%Colore e forma:Solid CrystallinePeso molecolare:241.25UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formula:C26H43N7O2Purezza:99.80%Colore e forma:SolidPeso molecolare:485.67NSC 146109 hydrochloride
CAS:NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.Formula:C17H17ClN2SPurezza:99.28%Colore e forma:SolidPeso molecolare:316.85
