Caspasi
Gli inibitori delle caspasi sono composti che bloccano l'attività delle caspasi, una famiglia di proteasi che sono esecutori centrali dell'apoptosi. Le caspasi clivano substrati specifici all'interno della cellula per innescare il processo apoptotico, portando alla morte cellulare programmata. Gli inibitori delle caspasi sono utilizzati per studiare i meccanismi dell'apoptosi, nonché per prevenire la morte cellulare indesiderata in vari modelli di ricerca. Questi inibitori sono anche esplorati in contesti terapeutici per proteggere le cellule dall'apoptosi in malattie come la neurodegenerazione. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle caspasi di alta qualità per supportare la tua ricerca in apoptosi, morte cellulare e campi correlati.
Trovati 144 prodotti di "Caspasi"
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Diclofenac
CAS:Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.Formula:C14H11Cl2NO2Purezza:99.69% - 99.97%Colore e forma:Crystals From Ether-Petroleum Ether SolidPeso molecolare:296.15ML-9
CAS:<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Formula:C15H18Cl2N2O2SPurezza:99.69%Colore e forma:Crystalline SolidPeso molecolare:361.29Ac-YVAD-CMK
CAS:<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Formula:C24H33ClN4O8Purezza:97.08% - 99.909%Colore e forma:SolidPeso molecolare:540.99Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Formula:C16H14O3Purezza:98.35% - 98.46%Colore e forma:White SolidPeso molecolare:254.28Thiabendazole
CAS:Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.Formula:C10H7N3SPurezza:99.14%Colore e forma:Light Yellow PowderPeso molecolare:201.25Crustecdysone
CAS:<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Formula:C27H44O7Purezza:99.06% - 99.67%Colore e forma:Canary Yellow Fine PowderPeso molecolare:480.63Diclofenac diethylamine
CAS:Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).Formula:C18H22Cl2N2O2Purezza:99.81% - 99.87%Colore e forma:SolidPeso molecolare:369.29Inclisiran sodium
CAS:Inclisiran (ALN-PCSsc) possesses antihypertensive activity, inhibiting the transcription of PCSK9, and can be used to research cardiovascular diseases.Purezza:99.29%Colore e forma:Odour SolidAc-FLTD-CMK
CAS:<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Formula:C26H37ClN4O8Purezza:95.17%Colore e forma:SolidPeso molecolare:569.05Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formula:C22H24ClNO4Purezza:99.53%Colore e forma:SolidPeso molecolare:401.88Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purezza:99.78% - 99.91%Colore e forma:White Solid CrystallinePeso molecolare:180.16Q-VD-OPH
CAS:Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.Formula:C26H25F2N3O6Purezza:97.8% - 98.95%Colore e forma:SolidPeso molecolare:513.5Terfenadine
CAS:Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.Formula:C32H41NO2Purezza:98.76% - 99.75%Colore e forma:SolidPeso molecolare:471.67Lacidipine
CAS:Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.Formula:C26H33NO6Purezza:99.98%Colore e forma:White-To-Off-White Crystalline SolidPeso molecolare:455.54Diclofenac sodium
CAS:<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Formula:C14H10Cl2NNaO2Purezza:98.21% - 99.73%Colore e forma:White Or Off-White PowderPeso molecolare:318.13Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Formula:C8H12ClNO3Purezza:98.34% - 99.85%Colore e forma:Physical Description Beige Solid (Ntp 1992)Peso molecolare:205.64Oxidopamine hydrobromide
CAS:Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.Formula:C8H12BrNO3Purezza:98.22% - 99.88%Colore e forma:Beige To Brown Fine Crystalline PowderPeso molecolare:250.09Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Formula:C17H22ClNO5Colore e forma:SolidPeso molecolare:355.81AKN-028
CAS:<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Formula:C17H14N6Purezza:99.88%Colore e forma:SolidPeso molecolare:302.33Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formula:C38H44O12Purezza:98%Colore e forma:SolidPeso molecolare:692.75δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formula:C10H12N4O2Purezza:99.84%Colore e forma:SolidPeso molecolare:220.23Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Colore e forma:Odour SolidSanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Formula:C40H38O11Colore e forma:SolidPeso molecolare:694.72TD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Formula:C55H70N8O9Colore e forma:SolidPeso molecolare:987.19IRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formula:C22H24N4O4SPurezza:99.88%Colore e forma:SolidPeso molecolare:440.52Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formula:C22H36N4O9Colore e forma:SolidPeso molecolare:500.54IRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formula:C18H20N2O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:360.43BOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formula:C11H18FNO5Purezza:97.02%Colore e forma:SolidPeso molecolare:263.26Trehalose-6,6'-dibehenate
CAS:Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formula:C56H106O13Peso molecolare:987.43Roxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Formula:C17H26N2O3Colore e forma:SolidPeso molecolare:306.4Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Formula:C32H46FN5O11Colore e forma:SolidPeso molecolare:695.742Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formula:C12H13ClN2OPurezza:99.4% - 99.97%Colore e forma:SolidPeso molecolare:236.7Perfluorodecanoic acid
CAS:Perfluorodecanoic acid is a biochemical.Formula:C10HF19O2Colore e forma:Physical Description Liquid (Ntp 1992)Peso molecolare:514.08Diethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormula:C13H36Cl4N4Purezza:99.79% - 99.86%Colore e forma:SolidPeso molecolare:390.26Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Formula:C37H42FN7O10Purezza:98%Colore e forma:SolidPeso molecolare:763.78Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formula:C33H41N7O11Colore e forma:SolidPeso molecolare:711.729Ac-WEHD-AFC TFA
Ac-WEHD-AFC TFA: a fluorogenic substrate detecting caspase-1 activity, used in tumor and inflammation research.Formula:C40H38F6N8O13Colore e forma:SolidPeso molecolare:952.77PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Formula:C26H29N5O7Purezza:98%Colore e forma:SolidPeso molecolare:523.54Ac-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formula:C32H38F3N5O11Purezza:99.16%Colore e forma:SolidPeso molecolare:725.67Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidTNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Colore e forma:Odour SolidVCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Colore e forma:Odour SolidBiotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Colore e forma:Odour SolidAc-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Formula:C28H33N7O9Colore e forma:SolidPeso molecolare:611.6(Iso)-Z-VAD(OMe)-FMK
CAS:(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formula:C22H30FN3O7Purezza:97.10%Colore e forma:SoildPeso molecolare:467.49Caspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Purezza:98%Colore e forma:Odour SolidAlmorexant hydrochloride
CAS:Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.Formula:C29H32ClF3N2O3Purezza:99.85%Colore e forma:SolidPeso molecolare:549.02J22352
CAS:J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects inFormula:C24H21N3O4Colore e forma:SolidPeso molecolare:415.44
