IAP
Gli inibitori delle proteine inibitorie dell'apoptosi (IAP) sono composti che bloccano l'attività delle IAP, una famiglia di proteine che prevengono l'apoptosi inibendo le caspasi e altri componenti della macchina apoptotica. Gli inibitori delle IAP promuovono l'apoptosi nelle cellule tumorali neutralizzando questi segnali di sopravvivenza, rendendoli strumenti importanti nella ricerca sul cancro e nella terapia. Presso CymitQuimica, offriamo una gamma completa di inibitori delle IAP di alta qualità per supportare la tua ricerca in oncologia, apoptosi e sviluppo terapeutico.
Trovati 67 prodotti di "IAP"
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MV1
CAS:MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.Formula:C33H44N4O5Purezza:99.86%Colore e forma:SolidPeso molecolare:576.73SBP-0636457
CAS:SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.Formula:C25H36N4O4Colore e forma:SolidPeso molecolare:456.587SM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Formula:C62H85ClN14O6Purezza:98%Colore e forma:SolidPeso molecolare:1157.88CST626
CAS:CST626 is a PROTAC degrader that targets XIAP, cIAP1, and cIAP2.Formula:C61H82N8O9SPurezza:95.87%Colore e forma:SolidPeso molecolare:1103.42XIAP BIR2/BIR2-3 inhibitor-1
CAS:XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Formula:C72H96N16O14Colore e forma:SolidPeso molecolare:1409.63S2/IAPinh
S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).Formula:C52H75Cl2FN6O6SPeso molecolare:1000.48299XIAP BIR2/BIR2-3 inhibitor-3
CAS:XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].Formula:C86H106N18O16S2Colore e forma:SolidPeso molecolare:1712MDM2/XIAP-IN-1
MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potentialColore e forma:Odour SolidAnti-CD47 Antibody (8A121)
Anti-CD47 Antibody (8A121) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (8A121) can be used in ELISA.Colore e forma:Odour LiquidAnti-CD47 Antibody (8K78)
<p>Anti-CD47 Antibody (8K78) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (8K78) can be used in WB,ELISA,IP.</p>Colore e forma:Odour LiquidAnti-CD47 Antibody (4E249)
Anti-CD47 Antibody (4E249) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (4E249) can be used in ELISA.Colore e forma:Odour LiquidAnti-CD47 Antibody (5R542)
Anti-CD47 Antibody (5R542) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (5R542) can be used in ELISA.Colore e forma:Odour LiquidAnti-CD47 Antibody (5K435)
<p>Anti-CD47 Antibody (5K435) is an antibody targeting CD47. Anti-CD47 Antibody (5K435) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidAnti-CD47 Antibody-PE (9X161)
<p>Anti-CD47 Antibody-PE (9X161) is a PE-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-PE (9X161) can be used in FCM.</p>Colore e forma:Odour LiquidAnti-CD47 Antibody (5S892)
Anti-CD47 Antibody (5S892) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (5S892) can be used in IHC-P.Colore e forma:Odour LiquidAnti-CD47 Antibody (9X161)
Anti-CD47 Antibody (9X161) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (9X161) can be used in FCM.Colore e forma:Odour LiquidAnti-CD47 Antibody-FITC (9X161)
<p>Anti-CD47 Antibody-FITC (9X161) is a FITC-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-FITC (9X161) can be used in FCM.</p>Colore e forma:Odour LiquidAnti-CD47 Antibody (4C168)
Anti-CD47 Antibody (4C168) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (4C168) can be used in IHC-P.Colore e forma:Odour LiquidAnti-CD47 Antibody (6T428)
Anti-CD47 Antibody (6T428) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (6T428) can be used in ELISA.Colore e forma:Odour LiquidAnti-CD47 Antibody (5E321)
Anti-CD47 Antibody (5E321) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (5E321) can be used in ELISA.Colore e forma:Odour LiquidAnti-CD47 Antibody (1F304)
Anti-CD47 Antibody (1F304) is an antibody targeting CD47. Anti-CD47 Antibody (1F304) can be used in ELISA, FCM.Colore e forma:Odour LiquidAZD5582
CAS:AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.Formula:C58H78N8O8Purezza:98.75%Colore e forma:SolidPeso molecolare:1015.29CD47 Protein, Mouse, Recombinant (His)
CD47 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Purezza:SDS-PAGE: 98.3%; SEC-HPLC: 98.5%Colore e forma:Lyophilized PowderPeso molecolare:15.3 kDa (predicted); 34-44 kDa (reducing condition, due to glycosylation)Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)
Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and isPurezza:92.7%Colore e forma:Lyophilized PowderPeso molecolare:54.1 kDa (predicted); 66 kDa (reducing conditions)CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag.Colore e forma:Lyophilized PowderPeso molecolare:30-40 KDa (reducing condition)CD47 Protein, Human, Recombinant (hFc)
CD47 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Purezza:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCColore e forma:Lyophilized PowderPeso molecolare:40.5 kDa (predicted); 55-65 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (mFc)
CD47 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag.Colore e forma:Lyophilized PowderPeso molecolare:48-65 KDa (reducing condition)CD47 Protein, Rhesus macaque, Recombinant (hFc)
<p>CD47 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:60-90 KDa (reducing condition)CD47 Protein, Human, Recombinant (aa 19-139, His)
<p>CD47 Protein, Human, Recombinant (aa 19-139, His) is expressed in HEK293 mammalian cells with His tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:14.5 kDa (predicted); 40-55 kDa (reducing conditions)Alkaline phosphatase (Intestinal type) /ALPI Protein, Human, Recombinant (His & Flag)
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletalColore e forma:Lyophilized PowderPeso molecolare:54.5 kDa (predicted). Due to glycosylation, the protein migrates to 63-73 kDa based on Tris-Bis PAGE result.CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag.Colore e forma:Lyophilized PowderPeso molecolare:60-70 KDa (reducing condition)Alkaline phosphatase (Intestinal type) /ALPI Protein, Mouse, Recombinant (His)
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletalColore e forma:Lyophilized PowderPeso molecolare:53.10 kDa (predicted). Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily.Colore e forma:Lyophilized PowderPeso molecolare:33-55 KDa (reducing condition)CD47 Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD47 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Colore e forma:Lyophilized PowderPeso molecolare:17.1 kDa (predicted); 38.8 kDa (reducing conditions)Alkaline phosphatase/ALPI Protein, Human, Recombinant (hFc)
Alkaline phosphatase Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:79.5 kDa (predicted); 90-95 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (aa 1-139, His)
CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag.Purezza:SDS-PAGE: 98.4%; SEC-HPLC: 97.6%Colore e forma:Lyophilized PowderPeso molecolare:15.2 kDa (predicted); 35-44 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (His)
CD47 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.Purezza:Greater than 95% as determined by reducing SDS-PAGE. - SDS-PAGE: 100%; SEC-HPLC: 97%Colore e forma:Lyophilized PowderPeso molecolare:30-45 KDa (reducing condition)CD47 Protein, Human, Recombinant, Biotinylated
CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells.Purezza:97.6%Colore e forma:Lyophilized PowderPeso molecolare:14.5 kDa (predicted)CD47 Protein, Mouse, Recombinant
CD47 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.8 kDa and the accession number is E5Q371.Colore e forma:Lyophilized PowderPeso molecolare:13.8 kDa (predicted)CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.Colore e forma:Lyophilized PowderPeso molecolare:15 kDa (predicted). Due to glycosylation, the protein migrates to 45-65 kDa based on Tris-Bis PAGE result.CD47 Protein, Mouse, Recombinant (hFc)
CD47 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:40.6 kDa (predicted)CD47 Protein, Human, Recombinant
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.Purezza:97.8%Colore e forma:Lyophilized PowderPeso molecolare:14.5 kDa (predicted); 35 kDa (reducing condition, due to glycosylation)Alkaline phosphatase/ALPI Protein, Human, Recombinant (His)
Alkaline phosphatase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Purezza:98.4%Colore e forma:Lyophilized PowderPeso molecolare:54 kDa (predicted); 66 kDa (reducing condition, due to glycosylation)CD47 Protein, Mouse, Recombinant (rFc)
CD47 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag.Colore e forma:Lyophilized PowderPeso molecolare:39.9 kDa (predicted)Embelin
CAS:Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Formula:C17H26O4Purezza:97.07% - 99.88%Colore e forma:SolidPeso molecolare:294.39Polygalacin D
CAS:Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-inducedFormula:C57H92O27Purezza:98.95% - ≥98%Colore e forma:SolidPeso molecolare:1209.4GDC-0152
CAS:GDC-0152 is a potent inhibitor of IAPs.Formula:C25H34N6O3SPurezza:97.18% - 99.32%Colore e forma:SolidPeso molecolare:498.64Birinapant
CAS:<p>Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of</p>Formula:C42H56F2N8O6Purezza:97.08% - ≥95%Colore e forma:SolidPeso molecolare:806.94BV6
CAS:<p>BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.</p>Formula:C70H96N10O8Purezza:97.46% - 99.82%Colore e forma:SolidPeso molecolare:1205.57AZD5582 acetate (1258392-53-8 free base)
AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.Formula:C60H82N8O10Purezza:97.76%Colore e forma:SolidPeso molecolare:1075.36Xevinapant
CAS:Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP, binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3.Formula:C32H43N5O4Purezza:98% - 99.94%Colore e forma:SolidPeso molecolare:561.71ASTX660
CAS:Tolinapant (ASTX660) is an orally bioavailable cIAP1/2 and XIAP antagonist.Cost-effective and quality-assured.Formula:C30H42FN5O3Purezza:98.33% - 99.85%Colore e forma:SolidPeso molecolare:539.68LCL161
CAS:LCL161 is a SMAC mimetic, an IAP antagonist with oral activity that inhibits XIAP and cIAP1. LCL161 has potential antitumor activity. Cost-effective and quality-assured.Formula:C26H33FN4O3SPurezza:99.13% - 99.87%Colore e forma:SolidPeso molecolare:500.63Isolinderalactone
CAS:Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.Formula:C15H16O3Purezza:98.76%Colore e forma:SolidPeso molecolare:244.294-Methylsalicylic acid
CAS:<p>4-Methylsalicylic acid is used to inhibit the medium chain acyl-CoA synthetase.</p>Formula:C8H8O3Purezza:99.64%Colore e forma:Solid Solid CrystallinePeso molecolare:152.15SM-164
CAS:SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.Formula:C62H84N14O6Purezza:98.53% - 99.92%Colore e forma:SolidPeso molecolare:1121.42MX69
CAS:MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Formula:C27H26N2O4SPurezza:97.27% - 99.57%Colore e forma:SolidPeso molecolare:474.57T-3256336
CAS:T-3256336 is an oral IAP blocker targeting cIAP-1, cIAP-2, and XIAP.Formula:C31H45F2N5O5Purezza:98%Colore e forma:SolidPeso molecolare:605.72MX107
CAS:MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.Formula:C24H28N2O2Colore e forma:SolidPeso molecolare:376.49NOC-5
CAS:NOC-5 is an NO donor that induces airway relaxation and concentration-dependently triggers 10 μM DAF-2 fluorescence.Formula:C6H16N4O2Purezza:98%Colore e forma:SolidPeso molecolare:176.22MDM2/XIAP-IN-3
CAS:MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressingFormula:C29H30N2O5SColore e forma:SolidPeso molecolare:518.62A 410099.1
CAS:<p>A 410099.1 is a BIRC (baculoviral IAP repeat-containing protein) inhibitor with EC50 values of 4.6, 9.2, 15.6, 19.9, and 93.9 nM for BIRC2/3/4/7/8.</p>Formula:C27H41ClN4O3Purezza:99.30%Colore e forma:SolidPeso molecolare:505.1CUDC-427
CAS:<p>CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.</p>Formula:C29H36N6O4SPurezza:99.92%Colore e forma:SolidPeso molecolare:564.7Anticancer agent 127
CAS:<p>Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM,</p>Formula:C26H37FN4O6SPurezza:98%Colore e forma:SolidPeso molecolare:552.66Anticancer agent 128
CAS:Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19Formula:C26H38N4O4Purezza:98%Colore e forma:SolidPeso molecolare:470.6XIAP/cIAP1 antagonist-1
<p>Potent oral XIAP/cIAP1 inhibitor with EC50s: XIAP 5.1 nM, cIAP1 0.32 nM; curbs tumor growth in vivo.</p>Colore e forma:SolidXIAP degrader-1
<p>XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).</p>Formula:C34H45N5O4Colore e forma:SolidPeso molecolare:587.75
