Chk
Gli inibitori delle chinasi di checkpoint (Chk) prendono di mira le chinasi Chk1 e Chk2, che sono regolatori chiave della risposta ai danni del DNA e dei punti di controllo del ciclo cellulare. Queste chinasi bloccano la progressione del ciclo cellulare in risposta ai danni al DNA, consentendo il tempo necessario per la riparazione. L'inibizione delle chinasi Chk può impedire l'arresto del ciclo cellulare, costringendo le cellule danneggiate a proseguire nel ciclo e a subire l'apoptosi. Gli inibitori di Chk sono particolarmente preziosi nella ricerca sul cancro, dove possono sensibilizzare le cellule tumorali agli agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una varietà di inibitori di Chk di alta qualità per supportare la tua ricerca sulla risposta ai danni del DNA, la regolazione del ciclo cellulare e l'oncologia.
Trovati 46 prodotti di "Chk"
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Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Purezza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:147 kDa (average)CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purezza:99.29%Colore e forma:SoildPeso molecolare:480.75Zimistobart
CAS:Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:LiquidCHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formula:C17H12N2O2SPurezza:98.40%Colore e forma:SolidPeso molecolare:308.35CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Colore e forma:SolidPeso molecolare:515.41Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formula:C16H18F3N7Colore e forma:SolidPeso molecolare:365.364CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.16002CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formula:C68H119N21O25SColore e forma:SolidPeso molecolare:1662.86GDC-0425
CAS:<p>GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.</p>Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purezza:98.02%Colore e forma:SolidPeso molecolare:328.32CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purezza:99.17%Colore e forma:SolidPeso molecolare:408.46GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Formula:C16H22BrCl2N5OColore e forma:SolidPeso molecolare:451.19CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurezza:98.28% - 99.93%Colore e forma:SolidPeso molecolare:379.34Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formula:C19H19ClN6OPurezza:97.78%Colore e forma:SolidPeso molecolare:382.85ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purezza:99.39%Colore e forma:SolidPeso molecolare:334.32AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurezza:98.96% - 99.19%Colore e forma:SolidPeso molecolare:362.42LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purezza:99.77%Colore e forma:SolidPeso molecolare:381.43M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurezza:99.02% - >99.99%Colore e forma:SolidPeso molecolare:404.48GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Formula:C16H20BrN5OPurezza:≥95%Colore e forma:SolidPeso molecolare:378.27GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Formula:C17H20ClFN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.88SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Formula:C15H13N5O2Purezza:98%Colore e forma:SolidPeso molecolare:295.3VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Formula:C19H20BrN5O2SColore e forma:SolidPeso molecolare:462.36TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFormula:C25H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:412.48PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Formula:C20H19N7O3Purezza:98%Colore e forma:SolidPeso molecolare:405.41NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurezza:98%Colore e forma:SolidPeso molecolare:580.66PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Formula:C18H17N7O3Colore e forma:SolidPeso molecolare:379.37CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Formula:C16H16F3N7OColore e forma:SolidPeso molecolare:379.34M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purezza:98.95%Colore e forma:SolidPeso molecolare:589.61CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurezza:98.78%Colore e forma:SolidPeso molecolare:405.46NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Formula:C23H17NO5SPurezza:98.31%Colore e forma:SolidPeso molecolare:419.45MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Formula:C15H15BrF3N7Colore e forma:SolidPeso molecolare:430.23CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:442.48VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purezza:98%Colore e forma:SolidPeso molecolare:538.64PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Colore e forma:SolidPeso molecolare:468.33CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purezza:97.13%Colore e forma:SolidPeso molecolare:478.95CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formula:C20H22N4OSPurezza:98%Colore e forma:SolidPeso molecolare:366.48CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formula:C18H19ClFN5OSPurezza:>99.99%Colore e forma:SolidPeso molecolare:407.89BBI-355
CAS:BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.40CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Colore e forma:SolidPeso molecolare:406.44CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formula:C18H18BrN7O2Purezza:98%Colore e forma:SolidPeso molecolare:444.29CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formula:C17H21BrN4OPurezza:98%Colore e forma:SolidPeso molecolare:377.28Chk1-IN-5
CAS:Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formula:C18H18FN7O2Colore e forma:SolidPeso molecolare:383.38PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formula:C19H19FN4O2SPurezza:99.4%Colore e forma:SolidPeso molecolare:386.44
