Chk
Gli inibitori delle chinasi di checkpoint (Chk) prendono di mira le chinasi Chk1 e Chk2, che sono regolatori chiave della risposta ai danni del DNA e dei punti di controllo del ciclo cellulare. Queste chinasi bloccano la progressione del ciclo cellulare in risposta ai danni al DNA, consentendo il tempo necessario per la riparazione. L'inibizione delle chinasi Chk può impedire l'arresto del ciclo cellulare, costringendo le cellule danneggiate a proseguire nel ciclo e a subire l'apoptosi. Gli inibitori di Chk sono particolarmente preziosi nella ricerca sul cancro, dove possono sensibilizzare le cellule tumorali agli agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una varietà di inibitori di Chk di alta qualità per supportare la tua ricerca sulla risposta ai danni del DNA, la regolazione del ciclo cellulare e l'oncologia.
Trovati 46 prodotti per "Chk".
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Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:371.42Ref: TM-T2485
5mg48,00€1mL*10mM (DMSO)65,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formula:C19H19ClN6OPurezza:97.78%Colore e forma:SolidPeso molecolare:382.85PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Formula:C18H17N7O3Colore e forma:SolidPeso molecolare:379.37AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Formula:C17H20ClFN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.88M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purezza:98.95%Colore e forma:White SolidPeso molecolare:589.61VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Formula:C19H20BrN5O2SColore e forma:SolidPeso molecolare:462.36SC-203885
CAS:SC-203885 is a checkpoint kinase 2 inhibitor.Formula:C15H13N5O2Purezza:98%Colore e forma:SolidPeso molecolare:295.3CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Formula:C16H16F3N7OColore e forma:SolidPeso molecolare:379.34NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurezza:98%Colore e forma:SolidPeso molecolare:580.66TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFormula:C25H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:412.48PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Formula:C20H19N7O3Purezza:98%Colore e forma:SolidPeso molecolare:405.41NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Formula:C23H17NO5SPurezza:98.31%Colore e forma:SolidPeso molecolare:419.45Ref: TM-T62204
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg268,00€25mg502,00€50mg703,00€100mg982,00€CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurezza:98.78%Colore e forma:SolidPeso molecolare:405.46Ref: TM-T10791
1mg168,00€2mg231,00€5mg371,00€1mL*10mM (DMSO)423,00€10mg558,00€25mg868,00€50mg1.153,00€100mg1.575,00€200mg2.125,00€CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purezza:99.90%Colore e forma:SolidPeso molecolare:478.95Ref: TM-T10718L
1mg70,00€2mg90,00€5mg150,00€1mL*10mM (DMSO)167,00€10mg227,00€25mg487,00€50mg807,00€100mg1.198,00€500mg2.412,00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:442.48VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purezza:98%Colore e forma:SolidPeso molecolare:538.64PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Colore e forma:SolidPeso molecolare:468.33MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Formula:C15H15BrF3N7Colore e forma:SolidPeso molecolare:430.23Chk1-IN-5
CAS:Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formula:C18H18FN7O2Colore e forma:SolidPeso molecolare:383.38Lisavanbulin
CAS:Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.Formula:C26H29N9O3Colore e forma:SolidPeso molecolare:515.57
