Chinesina
Gli inibitori delle chinesine prendono di mira le proteine motrici chinesine, responsabili del trasporto del carico cellulare lungo i microtubuli e che svolgono un ruolo chiave nella divisione cellulare, in particolare durante la mitosi. Le chinesine sono coinvolte nel movimento dei cromosomi e di altri organelli durante la divisione cellulare. Inibire le chinesine può interrompere questi processi, portando all'arresto del ciclo cellulare e alla possibile morte cellulare, rendendo questi inibitori preziosi nella ricerca sul cancro. Presso CymitQuimica, offriamo una gamma diversificata di inibitori delle chinesine di alta qualità per supportare la tua ricerca in biologia cellulare, mitosi e terapia del cancro.
Trovati 83 prodotti di "Chinesina"
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Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Formula:C26H31N7O4SPurezza:99.25%Colore e forma:SolidPeso molecolare:537.63Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Formula:C16H11N3Purezza:99.91%Colore e forma:SolidPeso molecolare:245.28BOS-172722
CAS:BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Formula:C24H30N8OPurezza:99.37%Colore e forma:SolidPeso molecolare:446.55TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formula:C30H33N7O2Purezza:97.39%Colore e forma:SolidPeso molecolare:523.63(S)-AM-9022
CAS:(S)-AM-9022 is the S-enantiomer of AM-9022, which is a potent and selective KIF18A inhibitor with oral bioavailability, applicable in cancer research.Formula:C27H36F2N6O4SPeso molecolare:578.67Mitotic kinesin-IN-3 hydrochloride
Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is an inhibitor of the mitotic motor protein (Mitotickinesin). It interferes with cell proliferation by inhibiting mitosis. This compound can be utilized in research relating to cancer, cardiac hypertrophy, immune and inflammatory diseases, as well as fungal infections.Colore e forma:Odour SolidKIF18A-IN-12
CAS:KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.Formula:C30H39F2N5O4SColore e forma:SolidPeso molecolare:603.72Solidagonic acid
CAS:Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Formula:C22H34O4Colore e forma:SolidPeso molecolare:362.5KIF18A-IN-15
CAS:KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Formula:C25H33F3N6O5SColore e forma:SolidPeso molecolare:586.63KIF18A-IN-14
CAS:<p>KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.</p>Formula:C26H32F3N5O6SColore e forma:SolidPeso molecolare:599.62Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Formula:C22H23F5N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:534.5Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formula:C35H39N9O3Colore e forma:SolidPeso molecolare:633.74KIF18A-IN-16
CAS:KIF18A-IN-16 (Compound 15) is a polycyclic KIF18A inhibitor. It is applicable in research related to tumors, including colon cancer, breast cancer, and lung cancer.Formula:C30H37N5O4SColore e forma:SolidPeso molecolare:563.71(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:292.35KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Formula:C28H38F2N6O4SPeso molecolare:592.26433CENP-E-IN-2
CENP-E-IN-2 (compound 3) is a photocontrollable CENP-E inhibitor exhibiting a pIC50 of 6.82 in the absence of light and a pIC50 of 5.85 under 365 nm light exposure. This compound also demonstrates antitumor activity.KIF18A-IN-6
CAS:KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Formula:C28H37N3O5S2Purezza:97.59%Peso molecolare:559.7411H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formula:C16H11NPurezza:99.14%Colore e forma:SolidPeso molecolare:217.27Eg5-IN-1
<p>Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.</p>Formula:C23H16ClFN4OPurezza:98.21%Colore e forma:SolidPeso molecolare:418.85KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Formula:C36H39ClN4O9SColore e forma:SolidPeso molecolare:738.21263GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formula:C20H11Cl2NO4Purezza:98%Colore e forma:SolidPeso molecolare:400.21AZ82
CAS:AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.Formula:C28H31F3N4O3SPurezza:99.31%Colore e forma:SolidPeso molecolare:560.63Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Formula:C20H16Br2N4O4Purezza:97.24%Colore e forma:SolidPeso molecolare:536.17ARQ 621
CAS:<p>ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.</p>Formula:C28H24Cl2FN5O2Purezza:97.01% - 98.38%Colore e forma:SolidPeso molecolare:552.43GW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formula:C20H11Cl2NO4Purezza:98.23%Colore e forma:SolidPeso molecolare:400.21Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formula:C29H26FN5O4SPurezza:97.45% - 99.4%Colore e forma:SolidPeso molecolare:559.61BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Formula:C16H14N2Purezza:97.81%Colore e forma:SolidPeso molecolare:234.3S-trityl-L-Cysteine
CAS:S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5Formula:C22H21NO2SPurezza:97.02%Colore e forma:Almost White To Light Yellow Granular PowderPeso molecolare:363.47CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purezza:97.52% - 99.52%Colore e forma:SolidPeso molecolare:500.33SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Formula:C31H34Cl2N2O3Purezza:95.58% - 99.70%Colore e forma:SolidPeso molecolare:553.52Mps1-IN-3 hydrochloride
Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.Formula:C26H32ClN7O4SColore e forma:SolidPeso molecolare:574.09Mps1-IN-1 dihydrochloride
CAS:Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.Formula:C28H35Cl2N5O4SColore e forma:SolidPeso molecolare:608.58Ispinesib
CAS:<p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>Formula:C30H33ClN4O2Purezza:98% - 99.09%Colore e forma:SolidPeso molecolare:517.06GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Formula:C32H38ClN5O4Purezza:96.22% - 98.02%Colore e forma:SolidPeso molecolare:592.13BTB-1
CAS:BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.Formula:C12H8ClNO4SPurezza:99.71%Colore e forma:SolidPeso molecolare:297.71Sovilnesib
CAS:Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.Formula:C26H34F2N6O4SPurezza:99.57%Colore e forma:SolidPeso molecolare:564.65K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Formula:C13H15N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:277.34Monastrol
CAS:<p>Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.</p>Formula:C14H16N2O3SPurezza:98.02% - 98.59%Colore e forma:SolidPeso molecolare:292.35Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formula:C16H18N2O2SPurezza:98.07%Colore e forma:SolidPeso molecolare:302.39AZ3146
CAS:<p>AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.</p>Formula:C24H32N6O3Purezza:97.84% - >99.99%Colore e forma:SolidPeso molecolare:452.55Mps1-IN-2
CAS:Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.Formula:C26H36N6O3Purezza:96.24% - 99.75%Colore e forma:SolidPeso molecolare:480.6BAY1217389
CAS:BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).Formula:C27H24F5N5O3Purezza:98.14% - 99.42%Colore e forma:SolidPeso molecolare:561.5Mps1-IN-1
CAS:<p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>Formula:C28H33N5O4SPurezza:98.33%Colore e forma:SolidPeso molecolare:535.66EMD534085
CAS:EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formula:C25H31F3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:476.53HR22C16
CAS:HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.Formula:C23H23N3O3Colore e forma:SolidPeso molecolare:389.45KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formula:C28H38N4O5S2Purezza:98.45%Colore e forma:SolidPeso molecolare:574.76(R)-Filanesib
CAS:(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48KIF18A-IN-4
CAS:KIF18A-IN-4: Non-competitive KIF18A inhibitor, IC50 6.16 μM, targets mitotic kinesins/kinases, anti-tumor.Formula:C22H27N3O3SColore e forma:SolidPeso molecolare:413.53SR31527
CAS:SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.Formula:C15H14ClN3OSPurezza:98%Colore e forma:SolidPeso molecolare:319.81CK0106023
CAS:CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Formula:C30H32BrClN4O2Colore e forma:SolidPeso molecolare:595.96TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Formula:C17H20N6OPurezza:98%Colore e forma:SolidPeso molecolare:324.38PF-2771
CAS:<p>PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.</p>Formula:C29H36ClN5O4Purezza:98%Colore e forma:SolidPeso molecolare:554.08Mps1-IN-4
CAS:Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formula:C26H31F3N6O2Colore e forma:SolidPeso molecolare:516.56Mps-BAY2b
CAS:Mps-BAY2b is a novel MPS1 inhibitor.Formula:C20H23N5OColore e forma:SolidPeso molecolare:349.43CFI-400936
CAS:CFI-400936: potent TTK inhibitor (IC50=3.6nM), potential anticancer, active in cell assays, selective vs. human kinases.Formula:C25H27N5O3SColore e forma:SolidPeso molecolare:477.58Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purezza:99.75%Colore e forma:SolidPeso molecolare:423.46Litronesib Racemate
CAS:Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.Formula:C23H37N5O4S2Colore e forma:SolidPeso molecolare:511.7Kif15-IN-1
CAS:Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Formula:C20H22N4O5SPurezza:99.39% - 99.39%Colore e forma:SolidPeso molecolare:430.48Syntelin
CAS:Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.Formula:C21H20N6O2S3Colore e forma:SolidPeso molecolare:484.62UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Formula:C17H17N3SPurezza:99.86%Colore e forma:SolidPeso molecolare:295.4CCT251455
CAS:<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Formula:C26H26ClN7O2Purezza:99.1% - 99.1%Colore e forma:SolidPeso molecolare:503.98SB-743921 free base
CAS:SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Formula:C31H33ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:517.06Litronesib
CAS:Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.Formula:C23H37N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:511.7KIF18A-IN-7
CAS:KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependentFormula:C27H35N3O5S2Colore e forma:SoildPeso molecolare:545.71CCT-271850
CAS:CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formula:C24H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:431.53PVZB1194
CAS:PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFormula:C13H9F4NO2SPurezza:98%Colore e forma:SolidPeso molecolare:319.28NTRC 0066-0
CAS:NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Formula:C33H39N7O2Purezza:98.30%Colore e forma:SolidPeso molecolare:565.71KSP-IA
CAS:KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Formula:C21H22F2N2OPurezza:98%Colore e forma:SolidPeso molecolare:356.41Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Formula:C20H20N6O4SPurezza:98.17%Colore e forma:SolidPeso molecolare:440.48Luvixasertib hydrochloride
CAS:CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].Formula:C28H31ClN6O3Colore e forma:SolidPeso molecolare:535.04MC-Val-Cit-PAB-Ispinesib
CAS:MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Formula:C59H71ClN10O10Colore e forma:SolidPeso molecolare:1115.71Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormula:C24H27N7O2Colore e forma:SolidPeso molecolare:445.52TNH
CAS:TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formula:C39H57ClN6O13Colore e forma:SolidPeso molecolare:853.36CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Formula:C28H30N6O3Purezza:96.66% - 99.51%Colore e forma:SolidPeso molecolare:498.58AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Formula:C27H36F2N6O4SColore e forma:SolidPeso molecolare:578.67RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formula:C35H40N8O2Colore e forma:SolidPeso molecolare:604.74MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formula:C23H19BrFN3O2Colore e forma:SolidPeso molecolare:468.318Mps1-IN-8
CAS:Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formula:C35H47N8O6PColore e forma:SolidPeso molecolare:706.77Mitotic kinesin-IN-1 hydrochloride
CAS:Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formula:C22H26ClF2N3OSColore e forma:SolidPeso molecolare:453.98Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formula:C25H38O4Colore e forma:SolidPeso molecolare:402.57NVP-BQS481
CAS:NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formula:C27H33F3N4O2Colore e forma:SolidPeso molecolare:502.57Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Colore e forma:SolidPeso molecolare:437.61EX05
CAS:EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Formula:C26H30F2N4O5SColore e forma:SolidPeso molecolare:548.60
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