Chinesina
Gli inibitori delle chinesine prendono di mira le proteine motrici chinesine, responsabili del trasporto del carico cellulare lungo i microtubuli e che svolgono un ruolo chiave nella divisione cellulare, in particolare durante la mitosi. Le chinesine sono coinvolte nel movimento dei cromosomi e di altri organelli durante la divisione cellulare. Inibire le chinesine può interrompere questi processi, portando all'arresto del ciclo cellulare e alla possibile morte cellulare, rendendo questi inibitori preziosi nella ricerca sul cancro. Presso CymitQuimica, offriamo una gamma diversificata di inibitori delle chinesine di alta qualità per supportare la tua ricerca in biologia cellulare, mitosi e terapia del cancro.
Trovati 87 prodotti di "Chinesina"
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TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formula:C30H33N7O2Purezza:97.39%Colore e forma:SolidPeso molecolare:523.63Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formula:C35H39N9O3Colore e forma:SolidPeso molecolare:633.74(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:292.35GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formula:C20H11Cl2NO4Purezza:98%Colore e forma:SolidPeso molecolare:400.21AZ82
CAS:AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.Formula:C28H31F3N4O3SPurezza:99.31%Colore e forma:SolidPeso molecolare:560.63Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Formula:C20H16Br2N4O4Purezza:97.24%Colore e forma:SolidPeso molecolare:536.17Ref: TM-T15663
2mg42,00€5mg62,00€10mg87,00€25mg159,00€50mg230,00€100mg346,00€200mg520,00€1mL*10mM (DMSO)73,00€Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formula:C16H18N2O2SPurezza:98.07%Colore e forma:SolidPeso molecolare:302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formula:C28H24Cl2FN5O2Purezza:97.01% - 98.38%Colore e forma:SolidPeso molecolare:552.43K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Formula:C13H15N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:277.34Monastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurezza:98.02% - 98.59%Colore e forma:SolidPeso molecolare:292.35Ref: TM-T4048
1mg48,00€5mg78,00€10mg97,00€25mg188,00€50mg311,00€100mg502,00€500mg1.074,00€1mL*10mM (DMSO)87,00€Mps1-IN-3 hydrochloride
Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.Formula:C26H32ClN7O4SColore e forma:SolidPeso molecolare:574.09SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Formula:C31H34Cl2N2O3Purezza:95.58% - 99.70%Colore e forma:SolidPeso molecolare:553.52Ref: TM-T2255
1mg42,00€5mg106,00€10mg163,00€25mg278,00€50mg429,00€100mg657,00€500mg1.501,00€1mL*10mM (DMSO)130,00€GW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formula:C20H11Cl2NO4Purezza:98.23%Colore e forma:SolidPeso molecolare:400.21Ref: TM-T9207L
1mg131,00€5mg286,00€10mg430,00€25mg647,00€50mg969,00€100mg1.301,00€1mL*10mM (DMSO)283,00€CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Formula:C23H21IN2O3Purezza:97.52% - 99.52%Colore e forma:SolidPeso molecolare:500.33Ref: TM-T6209
1mg40,00€5mg86,00€10mg118,00€25mg205,00€50mg290,00€100mg409,00€500mg888,00€1mL*10mM (DMSO)94,00€S-trityl-L-Cysteine
CAS:S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5Formula:C22H21NO2SPurezza:97.02%Colore e forma:Almost White To Light Yellow Granular PowderPeso molecolare:363.47Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formula:C29H26FN5O4SPurezza:97.45% - 99.4%Colore e forma:SolidPeso molecolare:559.61Ref: TM-T8487
1mg90,00€5mg183,00€10mg275,00€25mg449,00€50mg615,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)245,00€Sovilnesib
CAS:Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.Formula:C26H34F2N6O4SPurezza:99.57%Colore e forma:SolidPeso molecolare:564.65Ref: TM-T39994
1mg96,00€5mg235,00€10mg376,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)259,00€Ispinesib
CAS:<p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>Formula:C30H33ClN4O2Purezza:98% - 99.09%Colore e forma:SolidPeso molecolare:517.06AZ3146
CAS:AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.Formula:C24H32N6O3Purezza:97.84% - >99.99%Colore e forma:SolidPeso molecolare:452.55GSK-923295
CAS:GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).Formula:C32H38ClN5O4Purezza:96.22% - 98.02%Colore e forma:SolidPeso molecolare:592.13Ref: TM-T2039
1mg49,00€5mg97,00€10mg168,00€25mg283,00€50mg432,00€100mg605,00€200mg852,00€1mL*10mM (DMSO)136,00€
