Integrina
Gli inibitori delle integrine prendono di mira le integrine, una famiglia di recettori di superficie cellulare che svolgono un ruolo cruciale nell'adesione cellulare, nella migrazione e nella trasduzione del segnale. Le integrine sono coinvolte nella regolazione del ciclo cellulare, in particolare in processi come la divisione e la differenziazione cellulare. L'inibizione delle integrine può interrompere questi processi, portando all'arresto del ciclo cellulare e all'apoptosi, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro e nello studio delle metastasi. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle integrine di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la biologia del cancro e lo sviluppo terapeutico.
Trovati 256 prodotti di "Integrina"
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Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formula:C20H28N4O6Colore e forma:SolidPeso molecolare:420.46GSK-3008348
CAS:GSK-3008348 is an antagonist of integrin alpha(v)beta6.Formula:C29H37N5O2Purezza:99.547%Colore e forma:SolidPeso molecolare:487.64RUC-1
CAS:RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.Formula:C11H15N5OSPurezza:98%Colore e forma:SolidPeso molecolare:265.33Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Formula:C30H32Cl3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:604.95Integrin-IN-2
CAS:Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.Formula:C27H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:458.55IS-741 calcium
CAS:IS-741 calcium is a phospholipase A2 inhibitor.Formula:C30H38CaF6N6O6S2Colore e forma:SolidPeso molecolare:796.86BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Formula:C26H19Cl2N5O4Purezza:98.87%Colore e forma:SolidPeso molecolare:536.37CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:351.36Integrin modulator 1
CAS:Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Formula:C13H14N2O4Purezza:99.61%Colore e forma:SolidPeso molecolare:262.26Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Formula:C30H33Cl4N3O4Purezza:98%Colore e forma:SolidPeso molecolare:641.41TCS 2314
CAS:TCS 2314 is an orally active and selective very late antigen-4 antagonist (IC50: 4.4 nM).Formula:C28H34N4O6Purezza:98%Colore e forma:SolidPeso molecolare:522.59Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Formula:C56H60Br2N8O10SPurezza:98%Colore e forma:SolidPeso molecolare:1197.01Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Formula:C28H29BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:549.46IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Formula:C19H15NOS2Colore e forma:SolidPeso molecolare:337.46Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFormula:C27H27F2NO6Purezza:99.67%Colore e forma:SolidPeso molecolare:499.5Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formula:C22H32N4O4Purezza:98.76%Colore e forma:SolidPeso molecolare:416.51αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Formula:C29H38N4O4Purezza:98%Colore e forma:SolidPeso molecolare:506.64Bexotegrast HCl
CAS:Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Formula:C27H38Cl2N6O3Colore e forma:SolidPeso molecolare:565.543-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purezza:98%Colore e forma:SolidPeso molecolare:212.2ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Formula:C15H11BrN2O2SPurezza:99.67%Colore e forma:SolidPeso molecolare:363.23TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formula:C19H23N5O7Colore e forma:SolidPeso molecolare:433.42Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Formula:C24H28N4O6Purezza:98%Colore e forma:SolidPeso molecolare:468.5SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formula:C25H30N4O6Purezza:97.20%Colore e forma:SolidPeso molecolare:482.53L 738167
CAS:L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Formula:C25H34N6O6SColore e forma:SolidPeso molecolare:546.64α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Formula:C23H29N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:475.56JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formula:C29H38N4O3Purezza:98%Colore e forma:SolidPeso molecolare:490.64SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formula:C22H24F3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:451.44Zaurategrast
CAS:Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.Formula:C26H25BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:521.41Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Formula:C27H24Cl2N4O5Colore e forma:SolidPeso molecolare:555.41Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formula:C22H37ClN2O5SPurezza:98%Colore e forma:SolidPeso molecolare:477.06Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formula:C24H20N4O5Colore e forma:SolidPeso molecolare:444.44αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Formula:C21H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:386.49Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormula:C133H207N35O46Purezza:98%Colore e forma:SolidPeso molecolare:3032.27L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Formula:C22H26N4O5S3Colore e forma:SolidPeso molecolare:522.66TC-I 15
CAS:α2β1 integrin inhibitorFormula:C23H28N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:520.62BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Formula:C38H48N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:748.89Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formula:C19H31F3N8O11Colore e forma:SolidPeso molecolare:604.49Solitomab
CAS:Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.Purezza:95%Colore e forma:LiquidLotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Formula:C23H32N4O4Colore e forma:SolidPeso molecolare:428.52Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Purezza:95%Colore e forma:LiquidLotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Formula:C23H33ClN4O4Colore e forma:SolidPeso molecolare:464.99BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purezza:98%Colore e forma:SolidPeso molecolare:646.5ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formula:C23H35N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:597.64αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Formula:C26H34N6O6SPurezza:99.74% - >99.99%Colore e forma:SolidPeso molecolare:558.65Roxifiban acetate
CAS:Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormula:C23H33N5O8Purezza:97.91% - 98.36%Colore e forma:SolidPeso molecolare:507.54L 734217
CAS:L 734217 is an antagonist of the fibrinogen receptor.Formula:C18H31N3O4Purezza:98%Colore e forma:SolidPeso molecolare:353.46Des-ethyl-carafiban
CAS:Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formula:C22H23N5O5Colore e forma:SolidPeso molecolare:437.4486-B345TTQ
CAS:6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formula:C22H20BrNO4Colore e forma:SolidPeso molecolare:442.303α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formula:C24H26FN5O9Colore e forma:SolidPeso molecolare:547.49SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formula:C23H27F2N5O4Colore e forma:SolidPeso molecolare:475.49Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formula:C16H20Cl2N8O2SColore e forma:SolidPeso molecolare:459.35OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formula:C25H33N3O5Purezza:99.78%Colore e forma:SolidPeso molecolare:455.55Fradafiban
CAS:Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formula:C20H21N3O4Purezza:98%Colore e forma:SolidPeso molecolare:367.40GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Colore e forma:SolidPeso molecolare:485.59SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formula:C20H25N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:431.51GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Formula:C29H39N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:673.74
