Integrina
Gli inibitori delle integrine prendono di mira le integrine, una famiglia di recettori di superficie cellulare che svolgono un ruolo cruciale nell'adesione cellulare, nella migrazione e nella trasduzione del segnale. Le integrine sono coinvolte nella regolazione del ciclo cellulare, in particolare in processi come la divisione e la differenziazione cellulare. L'inibizione delle integrine può interrompere questi processi, portando all'arresto del ciclo cellulare e all'apoptosi, rendendo questi inibitori strumenti preziosi nella ricerca sul cancro e nello studio delle metastasi. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle integrine di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la biologia del cancro e lo sviluppo terapeutico.
Trovati 256 prodotti di "Integrina"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Colore e forma:Odour SolidFibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Formula:C38H64N8O15Purezza:98%Colore e forma:SolidPeso molecolare:872.96ASP5094
ASP5094 is a humanized anti-integrin α9 monoclonal antibody. It exhibits excellent safety and tolerability. ASP5094 can be utilized in the research of diseases such as rheumatoid arthritis.Colore e forma:Odour LiquidGamgertamig
CAS:Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Colore e forma:LiquidLDV FITC
CAS:fluorescent ligand that binds to the α4β1 integrin (VLA-4)Formula:C69H81N11O17SPurezza:98%Colore e forma:SolidPeso molecolare:1368.53Besufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Colore e forma:LiquidhuATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Colore e forma:Odour Liquidc(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Formula:C29H42F3N9O9Colore e forma:SolidPeso molecolare:717.69KGDS
CAS:KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Formula:C15H27N5O8Colore e forma:SolidPeso molecolare:405.4LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Formula:C48H70N10O12Purezza:98%Colore e forma:SolidPeso molecolare:979.13LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Formula:C32H43N11O15S2Colore e forma:SolidPeso molecolare:885.88Dafsolimab
CAS:Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and isColore e forma:LiquidIntegrin Binding Peptide
CAS:Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.Formula:C42H63N15O16SColore e forma:SolidPeso molecolare:1066.12Variabilin
CAS:Variabilin is a natural product that can be used as a reference standard. The CAS number of Variabilin is 3187-52-8.Formula:C17H16O5Colore e forma:SolidPeso molecolare:300.31MS133
<p>MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.</p>Colore e forma:Odour LiquidArg-Gly-Glu-Ser
CAS:<p>Arg-Gly-Glu-Ser is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets.</p>Formula:C16H29N7O8Purezza:98%Colore e forma:SolidPeso molecolare:447.44Batifiban
CAS:Batifiban, a glycoprotein IIb/IIIa antagonist, is used potentially for the treatment of coronary artery disease.Formula:C34H47N11O9S2Colore e forma:SolidPeso molecolare:817.93Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1DSPE-PEG5000-cRGD
DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.Colore e forma:Odour SolidR-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Formula:C56H65N9O14S3Colore e forma:SolidPeso molecolare:1184.36DSPE-PEG3000-iRGD
<p>DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.</p>Colore e forma:Odour SolidGRGDSPK TFA
<p>GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.</p>Formula:C30H50F3N11O13Colore e forma:SolidPeso molecolare:829.78GRGDSP
CAS:<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formula:C22H37N9O10Purezza:98%Colore e forma:SolidPeso molecolare:587.58α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFormula:C16H23F3N4O11Purezza:98%Colore e forma:SolidPeso molecolare:504.37PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formula:C17H12F3NO2Colore e forma:SolidPeso molecolare:319.278Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Formula:C46H54O16Purezza:98%Colore e forma:SolidPeso molecolare:862.91Fuzapladib
CAS:<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Formula:C15H20F3N3O3SPurezza:99.87%Colore e forma:SoildPeso molecolare:379.4DSPE-PEG1000-iRGD
DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.Colore e forma:Odour SolidOrbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFormula:C19H27N5O6Colore e forma:SolidPeso molecolare:421.45PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Formula:C24H37N3O4Purezza:99.92%Colore e forma:SoildPeso molecolare:431.57HSDVHK-NH2
CAS:Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Formula:C30H48N12O9Purezza:98%Colore e forma:SolidPeso molecolare:720.78AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColore e forma:SolidPeso molecolare:3161.32RTDLDSLRTYTL
CAS:RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Formula:C62H104N18O22Colore e forma:SolidPeso molecolare:1453.60Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formula:C25H41N11O8SColore e forma:SolidPeso molecolare:655.727Gly-Arg-Gly-Asp-Ser
CAS:<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formula:C17H30N8O9Purezza:98%Colore e forma:SolidPeso molecolare:490.47Obtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formula:C184H284N52O57S8Purezza:98%Colore e forma:SolidPeso molecolare:4393.07Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour Liquidα2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormula:C14H22N4O9Purezza:98%Colore e forma:SolidPeso molecolare:390.35DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Colore e forma:Odour SolidForimtamig
Forimtamig (RG-6324) is a bispecific antibody that targets GPRC5D and CD3 T cells. It features a 2 + 1 structure, comprising two high-affinity GPRC5D binding segments and one CD3-binding module. Forimtamig is engineered with a P329G LALA mutation in its Fc domain to prevent Fcγ receptor and C1q binding, while maintaining Fc receptor interaction. Its isotype control corresponds to human IgG1 kappa.Colore e forma:Odour LiquidDSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Colore e forma:Odour SolidEtrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Colore e forma:LiquidK34c hydrochloride
CAS:<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formula:C26H30ClN3O4Purezza:99.76% - 99.89%Colore e forma:SoildPeso molecolare:483.99A20FMDV2
CAS:<p>A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.</p>Formula:C93H163N31O28Colore e forma:SolidPeso molecolare:2163.48DSPE-PEG1000-cRGD
DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.Colore e forma:Odour SolidSMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38Fradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Formula:C20H22ClN3O4Colore e forma:SolidPeso molecolare:403.86αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Formula:C25H32ClN5O4Colore e forma:SolidPeso molecolare:502.012-Methylbutyrylcarnitine chloride
<p>2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.</p>Formula:C12H24ClNO4Colore e forma:SolidPeso molecolare:281.78STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purezza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:Odour Liquid
