LIM chinasi
Gli inibitori delle chinasi LIM prendono di mira le chinasi LIM, una famiglia di enzimi coinvolti nella regolazione del citoscheletro di actina e nella progressione del ciclo cellulare. Le chinasi LIM fosforilano e inattivano la cofilina, una proteina che disassembla i filamenti di actina, controllando così la forma, la motilità e la divisione cellulare. L'inibizione delle chinasi LIM può influenzare questi processi, portando a dinamiche alterate del ciclo cellulare e a una possibile apoptosi. Gli inibitori delle chinasi LIM sono strumenti importanti nella ricerca sul cancro e nello studio della motilità e dell'invasione cellulare. Presso CymitQuimica, offriamo una selezione di inibitori delle chinasi LIM di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, la dinamica del citoscheletro e l'oncologia.
Trovati 19 prodotti di "LIM chinasi"
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R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formula:C20H19ClN6O2Purezza:98.68%Colore e forma:SolidPeso molecolare:410.86S3 Fragment
<p>S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase</p>Formula:C73H120N18O24S2Colore e forma:SolidPeso molecolare:1697.978β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Formula:C15H18O4Colore e forma:SolidPeso molecolare:262.3BMS-3
CAS:<p>BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.</p>Formula:C17H12Cl2F2N4OSPurezza:99.31% - 99.81%Colore e forma:SolidPeso molecolare:429.27T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purezza:98.39% - 99.57%Colore e forma:SolidPeso molecolare:389.33BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formula:C17H14Cl2F2N4OSPurezza:98.01% - 99.88%Colore e forma:SolidPeso molecolare:431.29LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formula:C20H21BrN8Purezza:99.165%Colore e forma:SolidPeso molecolare:453.34TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formula:C21H20N2O3SPurezza:99.54%Colore e forma:SolidPeso molecolare:380.46TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurezza:98.23%Colore e forma:SolidPeso molecolare:422.54TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formula:C30H31N5O5S2Colore e forma:SolidPeso molecolare:605.73LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColore e forma:SolidPeso molecolare:461.54CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C20H18F3N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:421.44SR7826
CAS:SR7826 is a selective LIMK inhibitor.Formula:C22H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:387.43LIMK-IN-14
CAS:LIMK-IN-14 is an effective and selective inhibitor of LIMK.Formula:C22H27N7O3Purezza:98%Colore e forma:SolidPeso molecolare:437.49CRT-0105950
CAS:<p>CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Formula:C21H16ClN3OSPurezza:99.78% - 99.86%Colore e forma:SolidPeso molecolare:393.89LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formula:C23H29N7O3HClColore e forma:SolidPeso molecolare:488LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formula:C28H27N5O2Colore e forma:SolidPeso molecolare:465.55LIMK1 inhibitor 1
CAS:LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.Formula:C12H15N3S2Colore e forma:SolidPeso molecolare:265.398LIMK1 inhibitor 2
CAS:<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Formula:C10H11N3OSColore e forma:SolidPeso molecolare:221.279
