Ferroptosi
La ferroptosi è una forma di morte cellulare regolata caratterizzata dall'accumulo di perossidi lipidici e dallo stress ossidativo dipendente dal ferro. A differenza dell'apoptosi, la ferroptosi non è guidata dalle caspasi, ma piuttosto dal fallimento delle difese antiossidanti cellulari, che porta alla morte cellulare. Gli inibitori e gli induttori della ferroptosi sono fondamentali per studiare questa particolare via di morte cellulare, implicata in varie malattie, tra cui il cancro, la neurodegenerazione e il danno da ischemia-riperfusione. Presso CymitQuimica, offriamo una vasta gamma di modulatori della ferroptosi di alta qualità per supportare la tua ricerca sui meccanismi di morte cellulare, stress ossidativo e patologia delle malattie.
Trovati 226 prodotti di "Ferroptosi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Utreloxastat
CAS:Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis .Formula:C18H28O2Purezza:99.95%Colore e forma:SolidPeso molecolare:276.41Ref: TM-T60507
1mg92,00€5mg216,00€10mg311,00€25mg533,00€50mg787,00€100mg1.378,00€200mg1.853,00€1mL*10mM (DMSO)235,00€FA16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16Formula:C22H27F3N4O2SPurezza:99.44%Colore e forma:SolidPeso molecolare:468.54Deferitazole
CAS:Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.Formula:C18H25NO7SPurezza:99.48%Colore e forma:SolidPeso molecolare:399.46viFSP1
CAS:viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].Formula:C16H17N3O3SColore e forma:SolidPeso molecolare:331.39CP-24879 hydrochloride
CAS:<p>CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.</p>Formula:C11H18ClNOPurezza:98.08%Colore e forma:SolidPeso molecolare:215.72Ogremorphin
CAS:Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Formula:C21H17N3OSPurezza:99.65% - 99.65%Colore e forma:SolidPeso molecolare:359.44HAPSBC
CAS:HAPSBC, an S-benzyl iron chelator, modulates the intracellular distribution of ^59Fe [1].Formula:C15H15N3S2Colore e forma:SolidPeso molecolare:301.43Cerivastatin
CAS:Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.Formula:C26H34FNO5Purezza:97.80% - 99.56%Colore e forma:SolidPeso molecolare:459.55Docebenone
CAS:Docebenone is a selective and orally active inhibitor of 5-LO.Formula:C21H26O3Colore e forma:SolidPeso molecolare:326.43Lepadin H
CAS:Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancingFormula:C26H45NO3Purezza:98%Colore e forma:SolidPeso molecolare:419.64Lepadin E
CAS:Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.Formula:C26H47NO3Purezza:98%Colore e forma:SolidPeso molecolare:421.66GPX4 activator 2
CAS:GPX4 Activator 2 (Compound C3) serves as an activator of GPX4 and exhibits cardioprotective effects by inhibiting cellular iron death (ferroptosis) with an efficacy concentration (EC50) of 7.8 μM. It is used in the study of myocardial damage.Formula:C20H26N6O2SColore e forma:SolidPeso molecolare:414.52Ferroptosis-IN-15
CAS:Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.Formula:C17H14O5Colore e forma:SolidPeso molecolare:298.29DL-Buthionine-(S,R)-sulfoximine hydrochloride
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitorFormula:C8H19ClN2O3SColore e forma:SolidPeso molecolare:258.77CAR-2
CAS:<p>CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.</p>Formula:C27H23BF2I2N4O2Colore e forma:SolidPeso molecolare:738.114Ferroptosis-IN-6
CAS:Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Formula:C15H17NOPurezza:99.84%Colore e forma:SolidPeso molecolare:227.3Ref: TM-T86417
1mg57,00€5mg120,00€10mg187,00€25mg376,00€50mg605,00€100mg938,00€1mL*10mM (DMSO)133,00€Ferroptosis-IN-18
CAS:Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).Formula:C25H27N3SColore e forma:SolidPeso molecolare:401.567GPX4-IN-3
CAS:GPX4-IN-3 (26a) is a potent GPX4 inhibitor, inducing selective ferroptosis with 71.7% inhibition at 1 μM.Formula:C29H24ClN3O3SColore e forma:SolidPeso molecolare:530.04Nur77 agonist-1
CAS:Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.Formula:C24H18ClN5O2Colore e forma:SolidPeso molecolare:443.885GPX4-IN-13
CAS:GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM).Formula:C23H15NO3Colore e forma:SolidPeso molecolare:353.37Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Formula:C11H11NOSColore e forma:SolidPeso molecolare:205.28TfR-1-IN-1
CAS:TfR-1-IN-1 is a TfR-1 inhibitor, also a Fe(III) salivary phenol complex, inducing apoptosis and inhibiting tumor and normal cell growth.Formula:C20H12ClF2FeN2O2Purezza:96.96%Colore e forma:SolidPeso molecolare:441.62Microtubule inhibitor 2
Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.Formula:C20H23NO7Colore e forma:SolidPeso molecolare:389.4NPB-1575
CAS:NPB-1575 is a potent, orally active anti-inflammatory agent capable of crossing the blood-brain barrier. It mitigates neuroinflammation and resists ferroptosis by activating IRS2/Nrf2/NF-κB. NPB-1575 protects against cerebral ischemic injury and improves neurological function outcomes, making it suitable for research in focal ischemic stroke.Formula:C19H22O4Colore e forma:SolidPeso molecolare:314.38PRGL493
CAS:PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formula:C25H21N7O2Purezza:98.80% - 99.11%Colore e forma:SolidPeso molecolare:451.48Vatiquinone
CAS:Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhancFormula:C29H44O3Colore e forma:SolidPeso molecolare:440.66
