CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 525 prodotti di "CDK"
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CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurezza:99.07%Colore e forma:SolidPeso molecolare:410.9CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purezza:98%Colore e forma:SolidPeso molecolare:540.56CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Formula:C29H33F2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:553.6IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purezza:98%Colore e forma:SolidPeso molecolare:462.32KM05382
CAS:KM05382 inhibits CDK9 and the transcription of GAPDH.Formula:C20H19ClN2O3S2Colore e forma:SolidPeso molecolare:434.96CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Formula:C31H32FN7O3Purezza:99.54%Colore e forma:SolidPeso molecolare:569.63DCB-3503
CAS:DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Formula:C24H27NO5Colore e forma:SolidPeso molecolare:409.47CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45QR-6401
CAS:<p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>Formula:C19H23N5O3Purezza:98%Colore e forma:SolidPeso molecolare:369.42Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formula:C31H35ClN8O2Purezza:98.02% - 98.02%Colore e forma:SolidPeso molecolare:587.11CDK9-IN-9
CAS:<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Formula:C22H23F2N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:459.51Tacaciclib
CAS:Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].Formula:C30H36N6O3Purezza:98%Colore e forma:SolidPeso molecolare:528.65Palbociclib orotate
CAS:<p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>Formula:C29H33N9O6Purezza:98%Colore e forma:SolidPeso molecolare:603.63CDK4-IN-2
CAS:CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Formula:C22H26F2N6O4SPurezza:98%Colore e forma:SolidPeso molecolare:508.54Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFormula:C21H22N4OSPurezza:98%Colore e forma:SolidPeso molecolare:378.49LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formula:C23H33N7OPurezza:98%Colore e forma:SolidPeso molecolare:423.55(2S,3R)-Voruciclib
CAS:(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.Formula:C22H19ClF3NO5Purezza:98%Colore e forma:SolidPeso molecolare:469.84CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93CDK7-IN-14
CAS:<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formula:C22H24F3N6OPColore e forma:SolidPeso molecolare:476.43HQ005
CAS:HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formula:C15H15N5O2S2Colore e forma:SolidPeso molecolare:361.445-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Colore e forma:SolidPeso molecolare:403.17NU6300
CAS:NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formula:C20H23N5O3SPurezza:96.08%Colore e forma:SolidPeso molecolare:413.49PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formula:C25H27FN8O3SPurezza:99.02%Colore e forma:SolidPeso molecolare:538.6Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formula:C22H20Cl2F3NO5Purezza:98%Colore e forma:SolidPeso molecolare:506.3CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formula:C22H25F3N6Purezza:98%Colore e forma:SolidPeso molecolare:430.47Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Formula:C26H25ClN4O2Purezza:99.23%Colore e forma:SolidPeso molecolare:460.96Cdc7-IN-7
CAS:<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Formula:C21H22N4O5Purezza:98.78%Colore e forma:SolidPeso molecolare:410.42Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formula:C28H27N5OPurezza:98.06%Colore e forma:SolidPeso molecolare:449.55Senexin A hydrochloride
CAS:Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formula:C17H15ClN4Colore e forma:SolidPeso molecolare:310.78(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47CDK9-IN-19
CAS:CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Formula:C26H22F2N4O5Colore e forma:SolidPeso molecolare:508.47SHP2/CDK4-IN-1
CAS:SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Formula:C33H35ClF2N10OSColore e forma:SolidPeso molecolare:693.21CDK9-IN-23
CAS:CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formula:C22H25ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:428.91Inixaciclib
CAS:Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.Formula:C26H30F2N6OColore e forma:SolidPeso molecolare:480.55SZ-015268
CAS:SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formula:C25H38N8O3Colore e forma:SolidPeso molecolare:498.62CDK4/6-IN-15
CAS:CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Formula:C21H27FN8SColore e forma:SolidPeso molecolare:442.56EHT 5372
CAS:EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.Formula:C17H11Cl2N5OSColore e forma:SolidPeso molecolare:404.27Cdc7-IN-12
CAS:Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Formula:C16H14N2O2SColore e forma:SolidPeso molecolare:298.36Xylocydine
CAS:Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Formula:C12H14BrN5O5Colore e forma:SolidPeso molecolare:388.17ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formula:C18H14Cl3N3O2Colore e forma:SolidPeso molecolare:410.682CDK/HDAC-IN-3
CAS:CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,Formula:C24H18Cl2N6O3Purezza:98%Colore e forma:SolidPeso molecolare:509.34CF53
CAS:CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Formula:C24H25N7O2Purezza:99.72%Colore e forma:SolidPeso molecolare:443.5Debio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formula:C26H28Cl2N6OPurezza:99.93%Colore e forma:SolidPeso molecolare:511.45AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formula:C22H28ClN5O2Purezza:99% - 99.51%Colore e forma:SolidPeso molecolare:429.94XY028-140
CAS:<p>XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.</p>Formula:C39H40N10O7Purezza:98.59%Colore e forma:SolidPeso molecolare:760.8(R)-Simurosertib
CAS:<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Formula:C17H19N5OSPurezza:99.89%Colore e forma:SolidPeso molecolare:341.43Cdk1/2 Inhibitor III
CAS:<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Formula:C15H13F2N7O2S2Purezza:99.07%Colore e forma:SolidPeso molecolare:425.44DDO-6079
CAS:DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76CDK8-IN-9
<p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>Colore e forma:SolidCDK7-IN-33
CAS:CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Formula:C29H36N6O4SColore e forma:SolidPeso molecolare:564.699CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Formula:C20H18N4O4Colore e forma:SolidPeso molecolare:378.38PPA-037
CAS:<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formula:C25H27N7Colore e forma:SolidPeso molecolare:425.53CDK1-IN-3
CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.Formula:C28H25ClF3N5O2Colore e forma:SolidPeso molecolare:555.98CDK1-IN-7
CAS:<p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>Formula:C23H19ClN4O3Colore e forma:SolidPeso molecolare:434.88CDK7-IN-26
CAS:CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.Formula:C22H22FN6OPSPeso molecolare:468.49CDK9-IN-11
CAS:CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formula:C20H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:371.43Cimpuciclib tosylate
CAS:Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formula:C37H43FN8O4SColore e forma:SolidPeso molecolare:714.85CDK2 degrader 4
CAS:CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Formula:C23H26ClN3O5Colore e forma:SolidPeso molecolare:459.923LZ9
CAS:LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.Formula:C17H11F3N4O2Colore e forma:SolidPeso molecolare:360.29CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formula:C18H20F3N7O3S2Colore e forma:SolidPeso molecolare:503.52CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formula:C27H35N5O2Colore e forma:SolidPeso molecolare:461.6CLK1/2-IN-1
CAS:CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Formula:C21H20F3N7OPurezza:98%Colore e forma:SolidPeso molecolare:443.42CDK4/6-IN-24
CAS:CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.Formula:C32H41N7O3Colore e forma:SolidPeso molecolare:571.713PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Colore e forma:SolidZeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Formula:C18H20F3N4O2PColore e forma:SolidPeso molecolare:412.346CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formula:C18H14ClNO4SColore e forma:SolidPeso molecolare:375.83CDK2-IN-40
CAS:CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formula:C16H21N7O2Colore e forma:SolidPeso molecolare:343.384CDK4/6-IN-13
CAS:Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.Formula:C25H29N7OColore e forma:SolidPeso molecolare:443.54CDK2-IN-39
CAS:<p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>Formula:C14H15N3O4SColore e forma:SolidPeso molecolare:321.352CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formula:C26H26BrN5OColore e forma:SolidPeso molecolare:504.42Protein kinase inhibitor 11
CAS:Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.Formula:C21H18FN5O2SColore e forma:SolidPeso molecolare:423.463CDK2-IN-30
CAS:CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.Formula:C18H25N7O3SColore e forma:SolidPeso molecolare:419.50CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formula:C22H29ClN8Purezza:98%Colore e forma:SolidPeso molecolare:440.97Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formula:C12H8N4O2SColore e forma:SolidPeso molecolare:272.28YL-1-9
CAS:YL-1-9 is an inhibitor that prevents the degradation of p53 by MDM2 through tight binding to the crucial hydrophobic pocket of MDM2. It can induce cell cycle arrest and apoptosis in breast cancer cells [1].Formula:C22H23F3N2O3Colore e forma:SolidPeso molecolare:420.425CDK1-IN-5
CDK1-IN-5 is a selective inhibitor for CDK1 (IC50: 42.19 nM), CDK2, CDK5, halting cancer cell growth.Formula:C27H26ClN5OSColore e forma:SolidPeso molecolare:504.05p38α inhibitor 9
CAS:p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.Formula:C27H24FN3O3Colore e forma:SolidPeso molecolare:457.496CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.Formula:C22H25N5O3Colore e forma:SolidPeso molecolare:407.47Cdc7-IN-18
CAS:<p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formula:C11H14ClN3O3S2Colore e forma:SolidPeso molecolare:335.83CDK7-IN-18
CAS:CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.Formula:C22H24F3N7OSPurezza:99.28%Colore e forma:SolidPeso molecolare:491.53Cdc7-IN-11
CAS:Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Formula:C25H31FN8Purezza:98%Colore e forma:SolidPeso molecolare:462.57CDK4/9-IN-1
CAS:CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.Formula:C22H34N6O2Colore e forma:SolidPeso molecolare:414.544CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formula:C21H22N4OColore e forma:SolidPeso molecolare:346.43P162-0948
CAS:P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.Formula:C20H15FN4O2Colore e forma:SolidPeso molecolare:362.357CDK8-IN-14
CAS:<p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>Formula:C18H13N3O2Colore e forma:SolidPeso molecolare:303.31Anticancer agent 29
<p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>Formula:C22H15ClFNOColore e forma:SolidPeso molecolare:363.81DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formula:C18H26N4O3SColore e forma:SoildPeso molecolare:378.49DB18
CAS:DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Formula:C24H18ClN7O3Colore e forma:SolidPeso molecolare:487.9CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formula:C25H34N8OColore e forma:SolidPeso molecolare:462.59CDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Formula:C19H16ClF3N4O2Colore e forma:SolidPeso molecolare:424.8CDK7-IN-17
CAS:CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.Formula:C24H26F3N6OPPurezza:99.60%Colore e forma:SolidPeso molecolare:502.47CDK2-IN-18
CAS:<p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>Formula:C21H23N7O2SColore e forma:SolidPeso molecolare:437.52CDK2 degrader 6
CAS:CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formula:C23H22F5N5O3Colore e forma:SolidPeso molecolare:511.44GSK3-IN-10
CAS:GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.Formula:C17H18F2N4O3Colore e forma:SolidPeso molecolare:364.347PKMYT1-IN-7
CAS:PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formula:C17H18FN5O3Colore e forma:SolidPeso molecolare:359.355Cdc7-IN-19
CAS:Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.40Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.40INX-315
CAS:INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.Formula:C19H21N7O3SPurezza:99.88%Colore e forma:SolidPeso molecolare:427.48
