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CDK

CDK

Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.

Trovati 526 prodotti di "CDK"

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  • Indirubin-5-sulfonate
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    Indirubin-5-sulfonate

    CAS:
    Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.
    Formula:C16H10N2O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:342.33

    Ref: TM-T11653

  • CDK1-IN-1
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    CDK1-IN-1

    CAS:
    CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.
    Formula:C27H23N5O3
    Colore e forma:Solid
    Peso molecolare:465.5

    Ref: TM-T62970

  • Metralindole HCl
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    Metralindole HCl

    CAS:
    Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.
    Formula:C15H18ClN3O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:291.78

    Ref: TM-T28030

  • GW8510
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    GW8510

    CAS:
    GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.
    Formula:C21H15N5O3S2
    Purezza:99.32%
    Colore e forma:Solid
    Peso molecolare:449.51

    Ref: TM-T24125

  • CLK1-IN-1
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    CLK1-IN-1

    CAS:
    CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
    Formula:C24H16FN5O
    Colore e forma:Solid
    Peso molecolare:409.42

    Ref: TM-T10836

  • β-catenin-IN-3
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    β-catenin-IN-3

    CAS:
    β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the
    Formula:C19H20Br2N2OS
    Colore e forma:Solid
    Peso molecolare:484.25

    Ref: TM-T63212

  • XIE18-6
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    XIE18-6

    CAS:
    XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.
    Formula:C18H15NO6S
    Purezza:99.712%
    Colore e forma:Solid
    Peso molecolare:373.38

    Ref: TM-T29166

  • CDK4/6-IN-14
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    CDK4/6-IN-14

    CAS:
    CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.
    Formula:C24H27ClFN7O
    Colore e forma:Solid
    Peso molecolare:483.97

    Ref: TM-T72951

  • CDK4/6-IN-9
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    CDK4/6-IN-9

    CAS:
    CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.
    Formula:C22H23FN8
    Colore e forma:Solid
    Peso molecolare:418.47

    Ref: TM-T62192

  • Cdc7-IN-13
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    Cdc7-IN-13

    CAS:
    Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].
    Formula:C18H20N4O2S
    Colore e forma:Solid
    Peso molecolare:356.44

    Ref: TM-T61288

  • THZ1-R
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    THZ1-R

    CAS:
    THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.
    Formula:C31H30ClN7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:568.07

    Ref: TM-T13153

  • EGFR/HER2/CDK9-IN-1
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    EGFR/HER2/CDK9-IN-1

    CAS:
    EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.
    Formula:C23H21N3O3S2
    Colore e forma:Solid
    Peso molecolare:451.56

    Ref: TM-T62746

  • CDK7-IN-2
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    CDK7-IN-2

    CAS:
    CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.
    Formula:C26H39N7O3
    Colore e forma:Solid
    Peso molecolare:497.63

    Ref: TM-T63368

  • (S)-PF-06873600
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    (S)-PF-06873600

    CAS:
    (S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.
    Formula:C20H27F2N5O4S
    Purezza:98.59%
    Colore e forma:Solid
    Peso molecolare:471.52

    Ref: TM-T12809

  • hSMG-1 inhibitor 11e
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    hSMG-1 inhibitor 11e

    CAS:
    hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.
    Formula:C26H27N7O3S
    Purezza:99.89%
    Colore e forma:Solid
    Peso molecolare:517.6

    Ref: TM-T35529

  • CDK4/6/1 Inhibitor
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    CDK4/6/1 Inhibitor

    CAS:
    CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).
    Formula:C28H30F2N6
    Purezza:97.25% - 99.72%
    Colore e forma:Solid
    Peso molecolare:488.57

    Ref: TM-T10735

  • PS423
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    PS423

    CAS:
    PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.
    Formula:C25H23F3O9
    Purezza:98.81% - 99.26%
    Colore e forma:Solid
    Peso molecolare:524.44

    Ref: TM-T24676

  • DIF-3
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    DIF-3

    CAS:
    DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.
    Formula:C13H17ClO4
    Purezza:99.57%
    Colore e forma:Solid
    Peso molecolare:272.72

    Ref: TM-T60485

  • Abemaciclib metabolite M20
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    Abemaciclib metabolite M20

    CAS:
    Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。
    Formula:C27H32F2N8O
    Purezza:98.1% - 99.08%
    Colore e forma:Solid
    Peso molecolare:522.59

    Ref: TM-T10738

  • BML-259
    Targetmol
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    BML-259

    CAS:
    <p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>
    Formula:C14H16N2OS
    Purezza:99.84%
    Colore e forma:Solid
    Peso molecolare:260.35

    Ref: TM-T36964