CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 552 prodotti per "CDK". Vengono mostrati i primi 500.
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Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formula:C27H30O7Purezza:95.84% - 99.4%Colore e forma:SolidPeso molecolare:466.52Ref: TM-T16324
1mg67,00€5mg167,00€1mL*10mM (DMSO)180,00€10mg289,00€25mg595,00€50mg820,00€100mg1.108,00€200mg1.440,00€(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Formula:C19H18F2N4O2SPurezza:99.29%Colore e forma:White SolidPeso molecolare:404.43Ref: TM-T13467
1mg34,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg114,00€25mg205,00€50mg334,00€100mg537,00€200mg762,00€Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Formula:C24H32Cl2N8OPurezza:99.69% - 99.89%Colore e forma:SolidPeso molecolare:519.47Ca2+ channel agonist 1
CAS:Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.Formula:C19H26N6OPurezza:97.71%Colore e forma:SolidPeso molecolare:354.45Ref: TM-T10659
1mg92,00€5mg178,00€1mL*10mM (DMSO)207,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€Samuraciclib hydrochloride
CAS:Samuraciclib HCl is an oral CDK7 inhibitor (IC50: 41 nM), 45-230x selective over CDK1/2/5/9, inhibiting breast cancer growth (GI50: 0.2-0.3 μM).Formula:C22H31ClN6OPurezza:99.14% - 99.8%Colore e forma:SolidPeso molecolare:430.97Ref: TM-T10898
1mg108,00€2mg147,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg335,00€25mg595,00€50mg847,00€100mg1.153,00€CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formula:C23H18N6O2SPurezza:97.24% - 99.10%Colore e forma:SolidPeso molecolare:442.49Ref: TM-T14916
1mg82,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg304,00€25mg522,00€50mg713,00€100mg1.018,00€CDKI-73
CAS:CDKI-73: strong CDK9 blocker, Ki 4 nM, kills CLL cells selectively, aids cisplatin.Formula:C15H15FN6O2S2Purezza:98.11%Colore e forma:SolidPeso molecolare:394.45Ref: TM-T14919
1mg136,00€2mg178,00€5mg278,00€1mL*10mM (DMSO)290,00€10mg399,00€25mg658,00€50mg888,00€100mg1.251,00€(R)-CR8
CAS:(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.Formula:C24H29N7OPurezza:98.41%Colore e forma:SolidPeso molecolare:431.53Ref: TM-T12617L
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg200,00€25mg268,00€50mg409,00€100mg580,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purezza:98.07% - 99.52%Colore e forma:SolidPeso molecolare:338.41Ref: TM-T16021
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg197,00€50mg356,00€100mg537,00€Simurosertib
CAS:Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).Formula:C17H19N5OSPurezza:99.93% - 99.98%Colore e forma:SolidPeso molecolare:341.43Ref: TM-T12642L
1mg62,00€5mg150,00€1mL*10mM (DMSO)157,00€10mg203,00€25mg379,00€50mg533,00€100mg737,00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C27H36N8O5Purezza:99.90%Colore e forma:White SolidPeso molecolare:552.63Ref: TM-T15732
2mg34,00€5mg49,00€1mL*10mM (DMSO)60,00€10mg70,00€25mg92,00€50mg109,00€100mg165,00€200mg258,00€500mg459,00€CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Formula:C27H32F2N8Purezza:99.47%Colore e forma:SolidPeso molecolare:506.59Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Formula:C24H25N7OPurezza:99.95% - 99.96%Colore e forma:Yellow SolidPeso molecolare:427.5Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Formula:C26H36Cl2N8OPurezza:97.4%Colore e forma:SolidPeso molecolare:547.52Cyclin K degrader 1
Cyclin K degrader 1 is a Cyclin K degrader.Cyclin K degrader 1 is a degrader converted from AT-7519.Cyclin K degrader 1 has weak degrading activity against Cyclin K but does not result in a sustained decrease in degradation affinity.Cyclin K degrader 1 is a degrader converted from AT-7519.Formula:C23H17Cl2N5O2Purezza:99.76%Colore e forma:SolidPeso molecolare:466.32NVP-2
CAS:NVP-2 selectively inhibits CDK9 (IC50: 0.514 nM), prompts apoptosis, and affects other CDKs (IC50: 0.584-0.706 μM).Formula:C27H37ClN6O2Purezza:99.13%Colore e forma:Yellow SolidPeso molecolare:513.07Ref: TM-T16363
1mg52,00€2mg74,00€5mg113,00€1mL*10mM (DMSO)128,00€10mg192,00€25mg416,00€50mg615,00€100mg875,00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Formula:C22H15F2N5OPurezza:99.82%Colore e forma:SoildPeso molecolare:403.38Ref: TM-T77341
1mg315,00€5mg873,00€10mg1.080,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg3.537,00€AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Formula:C21H31N5O2Purezza:98.81%Colore e forma:SolidPeso molecolare:385.5Ref: TM-T14367
1mg93,00€5mg156,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg349,00€50mg494,00€100mg750,00€200mg1.009,00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purezza:98.33%Colore e forma:SolidPeso molecolare:422.52Ref: TM-T16359
2mg39,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formula:C17H16N4O3Purezza:98.62%Colore e forma:SolidPeso molecolare:324.33XPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Formula:C36H39ClFN7O2Purezza:99.63%Colore e forma:SoildPeso molecolare:656.19CDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formula:C21H20ClN3O2Purezza:98.55% - 99.22%Colore e forma:SoildPeso molecolare:381.86Ref: TM-T72048
1mg49,00€5mg96,00€1mL*10mM (DMSO)110,00€10mg142,00€25mg236,00€50mg344,00€100mg482,00€200mg658,00€hSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.Formula:C27H28ClN7O3SPurezza:99.22% - 99.65%Colore e forma:SolidPeso molecolare:566.07(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Formula:C31H30Cl3N7O2Purezza:99.51%Colore e forma:SolidPeso molecolare:638.98BRD6989
CAS:BRD6989, a cortistatin A analog, inhibits CDK8/19, enhances IL-10, and binds CDK8 with a 200 nM IC50.Formula:C16H16N4Purezza:99.43%Colore e forma:SolidPeso molecolare:264.33Ref: TM-T14778
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg177,00€50mg268,00€100mg398,00€200mg575,00€Amantadine hydrochloride
CAS:Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.Formula:C10H18ClNPurezza:99.98%Colore e forma:SolidPeso molecolare:187.71Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:414.45BSJ-03-204
CAS:BSJ-03-204 is a selective Cdk4/6 degrader.Formula:C43H48N10O8Colore e forma:SolidPeso molecolare:832.9Cdk2/Cyclin Inhibitory Peptide I
CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.Formula:C111H196N48O23Purezza:98%Colore e forma:SolidPeso molecolare:2571.05Ribociclib-D6 hydrochloride
Ribociclib-D6 hydrochloride is a deuterated form of Ribociclib hydrochloride (T15730), which is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and has over 1000-fold lower activity against the cyclin B/CDK1 complex.CDK4/6-IN-5
CAS:CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Formula:C22H28ClFN6O4SColore e forma:SolidPeso molecolare:527.01JH-XI-10-02
CAS:JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.Formula:C53H69N5O9Purezza:98%Colore e forma:SolidPeso molecolare:920.161TMX-2138
CAS:TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.Formula:C40H43BrFN9O11SColore e forma:SolidPeso molecolare:956.791EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2.Formula:C24H16N6OS2Purezza:98%Colore e forma:SolidPeso molecolare:468.55JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Formula:C22H22ClN7OColore e forma:SolidPeso molecolare:435.92CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.Formula:C32H34FN7O4Colore e forma:SolidPeso molecolare:599.655YX0597
YX0597 is a potent and selective CDK9 PROTAC degrader that reduces RNA polymerase II S2 phosphorylation and MCL1 expression in GA0518 and AGS cells. It effectively inhibits the growth of GEAC cells (including radioresistant tumors) and suppresses tumor proliferation, metastasis, and cancer stem cells.Colore e forma:Odour SolidCDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formula:C24H22FN7O2Colore e forma:SolidPeso molecolare:459.48PP-C8
PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.Formula:C43H51FN12O7Colore e forma:SolidPeso molecolare:866.94CDK12-IN-6
CAS:CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).Formula:C20H21F2N9Colore e forma:SolidPeso molecolare:425.448Multi-target kinase inhibitor 2
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 valuesPurezza:98%Colore e forma:Odour SolidCDK7-IN-7
CAS:CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Formula:C20H20BrF3N6O2Colore e forma:SolidPeso molecolare:513.319LO-3-63
LO-3-63 is a Ribociclib analogue featuring a truncated fumaramide group and acts as a CDK4/6 degrader with PROTAC properties. It degrades CDK4/6 in cells via a CUL4DCAF16-dependent pathway.Colore e forma:Odour SolidIV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formula:C23H32FN5O2SiColore e forma:SolidPeso molecolare:457.625EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively.Formula:C49H32N12O2S2Purezza:98%Colore e forma:SolidPeso molecolare:884.99CDK9 inhibitor HH1
CAS:CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.Formula:C13H15N3OSPurezza:99.92%Colore e forma:SolidPeso molecolare:261.34CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.Colore e forma:Odour SolidPROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formula:C39H48Cl2N10O5Colore e forma:SolidPeso molecolare:807.768PROTAC CDK9 degrader 4
CAS:PROTAC CDK9 degrader 4 is a CDK9 degrader that targets transcriptional regulation and has potential anticancer activity.Formula:C43H56N10O5Colore e forma:SolidPeso molecolare:792.97CDK9 ligand 3
CAS:CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formula:C18H18BrCl2N5O3Colore e forma:SolidPeso molecolare:503.177
