CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 550 prodotti per "CDK".
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IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purezza:98%Colore e forma:SolidPeso molecolare:462.32CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purezza:98%Colore e forma:SolidPeso molecolare:540.56Cdc7-IN-12
CAS:Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Formula:C16H14N2O2SColore e forma:SolidPeso molecolare:298.36(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47CDK4/6-IN-15
CAS:CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Formula:C21H27FN8SColore e forma:SolidPeso molecolare:442.56SZ-015268
CAS:SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formula:C25H38N8O3Colore e forma:SolidPeso molecolare:498.62CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45KM05382
CAS:KM05382 inhibits CDK9 and the transcription of GAPDH.Formula:C20H19ClN2O3S2Colore e forma:SolidPeso molecolare:434.96Senexin A hydrochloride
CAS:Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formula:C17H15ClN4Colore e forma:SolidPeso molecolare:310.78NU6300
CAS:NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formula:C20H23N5O3SPurezza:96.08%Colore e forma:SolidPeso molecolare:413.49Nε-(1-Carboxyethyl)-L-lysine
CAS:Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.Formula:C9H18N2O4Purezza:97.84%Colore e forma:White SolidPeso molecolare:218.25CDK9-IN-19
CAS:CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Formula:C26H22F2N4O5Colore e forma:SolidPeso molecolare:508.47PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formula:C25H27FN8O3SPurezza:99.02%Colore e forma:SolidPeso molecolare:538.6Lerociclib
CAS:Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Formula:C26H34N8OPurezza:99%Colore e forma:SolidPeso molecolare:474.6Riviciclib
CAS:Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Formula:C21H20ClNO5Purezza:98%Colore e forma:SolidPeso molecolare:401.84AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formula:C22H28ClN5O2Purezza:99% - 99.51%Colore e forma:SolidPeso molecolare:429.94Cdk1/2 Inhibitor III
CAS:Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Formula:C15H13F2N7O2S2Purezza:99.92%Colore e forma:SolidPeso molecolare:425.44CF53
CAS:CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Formula:C24H25N7O2Purezza:99.72%Colore e forma:SolidPeso molecolare:443.5Ref: TM-T10773
1mg92,00€5mg200,00€1mL*10mM (DMSO)215,00€10mg299,00€25mg484,00€50mg658,00€100mg892,00€Debio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formula:C26H28Cl2N6OPurezza:99.93%Colore e forma:SolidPeso molecolare:511.45(R)-Simurosertib
CAS:(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Formula:C17H19N5OSPurezza:99.89%Colore e forma:SolidPeso molecolare:341.43XY028-140
CAS:XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.Formula:C39H40N10O7Purezza:98.59%Colore e forma:SolidPeso molecolare:760.8CDK1-IN-7
CAS:CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.Formula:C23H19ClN4O3Colore e forma:SolidPeso molecolare:434.88CDK2-IN-18
CAS:CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].Formula:C21H23N7O2SColore e forma:SolidPeso molecolare:437.52Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formula:C11H14ClN3O3S2Colore e forma:SolidPeso molecolare:335.83CDK2 degrader 6
CAS:CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formula:C23H22F5N5O3Colore e forma:SolidPeso molecolare:511.44INX-315
CAS:INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.Formula:C19H21N7O3SPurezza:99.88%Colore e forma:White SolidPeso molecolare:427.48Ref: TM-T86723
50mgPrezzo su richiesta1mg70,00€5mg150,00€1mL*10mM (DMSO)178,00€10mg264,00€25mg358,00€CDDD11-8
CAS:CDDD11-8 is an orally administered, highly potent and selective CDK9 and FLT3-ITD inhibitor, with K i values of 8 nM and 13 nM, respectively. It effectively reduces the proliferation of leukemia cell lines, showing particular efficacy against those with the FLT3-ITD mutation [1] [2].Formula:C24H26N6Colore e forma:SolidPeso molecolare:398.50Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formula:C12H8N4O2SColore e forma:SolidPeso molecolare:272.28CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formula:C26H26BrN5OColore e forma:SolidPeso molecolare:504.42CDK2-IN-31
CAS:CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formula:C37H52N6O5Colore e forma:SolidPeso molecolare:660.85SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formula:C19H15F3N6O2Colore e forma:SolidPeso molecolare:416.36CDK1-IN-4
CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.Formula:C26H24ClN5SColore e forma:SolidPeso molecolare:474.02CDK8-IN-5
CAS:CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Formula:C26H22N2O4Colore e forma:SolidPeso molecolare:426.46PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Colore e forma:SolidCDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Formula:C19H16ClF3N4O2Colore e forma:SolidPeso molecolare:424.8CDK9-IN-34
CAS:CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.Formula:C18H20N4Colore e forma:SolidPeso molecolare:292.38CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formula:C19H15F3N4O2Purezza:99.74%Colore e forma:White SolidPeso molecolare:388.34Ref: TM-T61742
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg982,00€RGB-286638
CAS:RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.Formula:C29H37Cl2N7O4Colore e forma:SolidPeso molecolare:618.55Cdc7-IN-10
CAS:Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48Haspin-IN-2
CAS:Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Formula:C12H8N4O3Colore e forma:SolidPeso molecolare:256.22Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.40CDK7-IN-17
CAS:CDK7-IN-17 (compound 11) is a pyrimidine-derived CDK7 inhibitor for studying transcription-disrupted cancers.Formula:C24H26F3N6OPPurezza:99.60%Colore e forma:White SolidPeso molecolare:502.47CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formula:C25H34N8OColore e forma:SolidPeso molecolare:462.59DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formula:C18H26N4O3SColore e forma:SolidPeso molecolare:378.49Cdc7-IN-11
CAS:Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formula:C18H14ClNO4SColore e forma:SolidPeso molecolare:375.83CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formula:C27H35N5O2Colore e forma:SolidPeso molecolare:461.6CDK1-IN-3
CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.Formula:C28H25ClF3N5O2Colore e forma:SolidPeso molecolare:555.98CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Formula:C20H18N4O4Colore e forma:SolidPeso molecolare:378.38CDK7-IN-33
CAS:CDK7-IN-33 (Compound 148) is a CDK7 inhibitor with a Ki value of 21.75 nM. It suppresses the proliferation of A549 cells expressing CDK7WT, with a pIC50 of 7.37.Formula:C29H36N6O4SColore e forma:SolidPeso molecolare:564.699
