CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 522 prodotti di "CDK"
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KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formula:C16H27Cl2N5Purezza:99.79%Colore e forma:SolidPeso molecolare:360.33(E/Z)-TG003
CAS:(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.Formula:C13H15NO2SPurezza:98% - 99.04%Colore e forma:SolidPeso molecolare:249.33AT7519
CAS:AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.Formula:C16H17Cl2N5O2Purezza:98.88% - 99.65%Colore e forma:SolidPeso molecolare:382.24NSC23005
CAS:<p>NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).</p>Formula:C13H17NO4SPurezza:>99.99%Colore e forma:SolidPeso molecolare:283.34SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formula:C20H26ClN7Purezza:99.18%Colore e forma:SolidPeso molecolare:399.92BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Formula:C22H20N4OPurezza:96.7% - 99.63%Colore e forma:SolidPeso molecolare:356.42AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurezza:>99.99%Colore e forma:SolidPeso molecolare:405.24SU9516
CAS:<p>SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.</p>Formula:C13H11N3O2Purezza:99.34% - 99.87%Colore e forma:SolidPeso molecolare:241.25Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Formula:C24H29N7O2·C2H6O4SPurezza:99.01% - 99.27%Colore e forma:SolidPeso molecolare:573.66Wogonin
CAS:<p>Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.</p>Formula:C16H12O5Purezza:98% - 99.8%Colore e forma:Yellow CrystalPeso molecolare:284.26CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formula:C22H20BrN3O3SPurezza:99.66%Colore e forma:SolidPeso molecolare:486.38TC11
CAS:<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Formula:C20H22N2O2Purezza:97.86%Colore e forma:SolidPeso molecolare:322.4SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purezza:99.88%Colore e forma:SolidPeso molecolare:376.25LY2857785
CAS:LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Formula:C26H36N6OPurezza:99.68%Colore e forma:Solid PowderPeso molecolare:448.6BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Formula:C20H27N5O3Purezza:99.85%Colore e forma:SolidPeso molecolare:385.46AMG 925
CAS:AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Formula:C26H29N7O2Purezza:99.75%Colore e forma:SolidPeso molecolare:471.55AUZ 454
CAS:<p>AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.</p>Formula:C24H26F3N7O2Purezza:99.59%Colore e forma:SolidPeso molecolare:501.5Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:447.53Bromosporine
CAS:<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>Formula:C17H20N6O4SPurezza:99.65% - 99.79%Colore e forma:SolidPeso molecolare:404.44PHA-793887
CAS:<p>PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.</p>Formula:C19H31N5O2Purezza:98.02% - >99.99%Colore e forma:SolidPeso molecolare:361.48BMS-265246
CAS:<p>BMS-265246 is a potent and selective CDK1/2 inhibitor.</p>Formula:C18H17F2N3O2Purezza:99.25% - 99.57%Colore e forma:SolidPeso molecolare:345.34HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Formula:C15H15N5OS2Purezza:98.11%Colore e forma:SolidPeso molecolare:345.44AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Formula:C16H18Cl3N5O2Purezza:99.66% - 99.9%Colore e forma:SolidPeso molecolare:418.712-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Formula:C4H3ClN2Purezza:98.98% - 99.89%Colore e forma:Clear Colorless To Yellowish LiquidPeso molecolare:114.53LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Formula:C23H29ClN8OPurezza:100%Colore e forma:SolidPeso molecolare:469.02THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Formula:C30H32ClN7O2Purezza:97.17% - 99.86%Colore e forma:SolidPeso molecolare:558.07M2N12
CAS:M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.Formula:C20H16ClN5O2Purezza:98.01%Colore e forma:SolidPeso molecolare:393.83LSN2839567
CAS:<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Formula:C25H28F2N8Purezza:99.14%Colore e forma:SolidPeso molecolare:478.54CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Formula:C18H15F5N8OPurezza:99.37%Colore e forma:SolidPeso molecolare:454.36AZ5576
CAS:<p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>Formula:C21H24FN3O3Purezza:99.88%Colore e forma:SoildPeso molecolare:385.43(R)-(+)-O-Demethylbuchenavianine
CAS:(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Formula:C21H21NO4Colore e forma:SolidPeso molecolare:351.40Riviciclib hydrochloride
CAS:Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Formula:C21H20ClNO5·HClPurezza:99.51%Colore e forma:SolidPeso molecolare:438.3XL413
CAS:XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Formula:C14H12ClN3O2Purezza:98.40% - 99.94%Colore e forma:SolidPeso molecolare:289.72Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Formula:C15H18ClN3OPurezza:98%Colore e forma:SolidPeso molecolare:291.78CCT068127
CAS:CCT068127 is a potent CDK2 and CDK9 inhibitor.Formula:C19H27N7OColore e forma:SolidPeso molecolare:369.46(S)-CR8
CAS:(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Formula:C24H29N7OColore e forma:SolidPeso molecolare:431.53EGFR/CDK2-IN-1
CAS:EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFormula:C19H12BrClO2Colore e forma:SolidPeso molecolare:387.65NSC 693868
CAS:CDKs and GSK-3 inhibitorFormula:C9H7N5Purezza:98%Colore e forma:SolidPeso molecolare:185.19CDK7-IN-15
CAS:CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.Formula:C21H24F4N6OSPurezza:99.27%Colore e forma:SolidPeso molecolare:484.51(S)-LY3177833 hydrate
CAS:(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.Formula:C16H14FN5O2Colore e forma:SolidPeso molecolare:327.31CDK2-IN-13
CAS:CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.Formula:C13H12ClN5Colore e forma:SoildPeso molecolare:273.72CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Formula:C16H11N3OSPurezza:99.32%Colore e forma:SolidPeso molecolare:293.34Zotiraciclib HCl
CAS:Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formula:C23H26Cl2N4OColore e forma:SolidPeso molecolare:445.388EGFR/HER2/CDK9-IN-2
CAS:EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.Formula:C23H20N4O5S2Colore e forma:SolidPeso molecolare:496.56CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Formula:C29H35N7O3Colore e forma:SolidPeso molecolare:529.63Cdc7-IN-9
CAS:Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].Formula:C15H17N5OSColore e forma:SolidPeso molecolare:315.39NSC 625987
CAS:Cyclin-dependent kinase (cdk) 4 inhibitorFormula:C15H13NO2SPurezza:98%Colore e forma:SolidPeso molecolare:271.33CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Formula:C12H10N6Colore e forma:SolidPeso molecolare:238.25Cdc7-IN-14
CAS:<p>Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.</p>Formula:C18H20N4O2SColore e forma:SolidPeso molecolare:356.44Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Formula:C15H17N3OColore e forma:SolidPeso molecolare:255.32
