CDK
Gli inibitori delle chinasi ciclina-dipendenti (CDK) sono composti che bloccano l'attività delle CDK, un gruppo di chinasi proteiche che regolano il ciclo cellulare, la trascrizione e altri processi cellulari. Le CDK vengono attivate legandosi alle cicline e la loro attività è cruciale per la progressione delle cellule attraverso le diverse fasi del ciclo cellulare. Inibire le CDK può bloccare la divisione cellulare, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali in cui le CDK sono spesso disregolate. Gli inibitori delle CDK sono ampiamente utilizzati nella ricerca sul cancro e hanno un potenziale terapeutico nel trattamento di vari tipi di cancro. Presso CymitQuimica, offriamo una selezione completa di inibitori delle CDK di alta qualità per supportare la tua ricerca sul controllo del ciclo cellulare, sul cancro e sullo sviluppo terapeutico.
Trovati 522 prodotti di "CDK"
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Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Formula:C12H14N4OSColore e forma:SolidPeso molecolare:262.33CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formula:C23H28F2N8OPurezza:99.85%Colore e forma:SolidPeso molecolare:470.52CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formula:C20H18N4OColore e forma:SolidPeso molecolare:330.38EGFR/HER2/CDK9-IN-1
CAS:EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.Formula:C23H21N3O3S2Colore e forma:SolidPeso molecolare:451.56CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Formula:C26H39N7O3Colore e forma:SolidPeso molecolare:497.63Atuveciclib S-Enantiomer
CAS:<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Formula:C18H18FN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:387.43CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Formula:C16H12Cl2N2O2SColore e forma:SolidPeso molecolare:367.25SNX2-1-108
CAS:SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.Formula:C21H16N4Purezza:98%Colore e forma:SolidPeso molecolare:324.38CDK4/6-IN-7
CAS:<p>CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.</p>Formula:C18H18ClN5O3Colore e forma:SolidPeso molecolare:387.82BAY-958
CAS:BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.Formula:C17H16FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:389.4Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Formula:C19H26N6O2Purezza:99.94%Colore e forma:SolidPeso molecolare:370.45CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.37P18IN003
CAS:<p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>Formula:C17H16N2O3Purezza:98.77%Colore e forma:SolidPeso molecolare:296.32β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormula:C19H20Br2N2OSColore e forma:SolidPeso molecolare:484.25CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Formula:C20H19F3N6Colore e forma:SolidPeso molecolare:400.4GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formula:C21H15N5O3S2Purezza:99.32%Colore e forma:SolidPeso molecolare:449.51Crozbaciclib fumarate
CAS:Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Formula:C32H34F2N6O4Colore e forma:SolidPeso molecolare:604.65Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formula:C13H15N5OSColore e forma:SolidPeso molecolare:289.36FN-1501
CAS:<p>FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).</p>Formula:C22H25N9OPurezza:97.4%Colore e forma:SolidPeso molecolare:431.49BS-181
CAS:BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Formula:C22H32N6Purezza:98%Colore e forma:SolidPeso molecolare:380.53BRD7389
CAS:BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Formula:C24H18N2O2Purezza:99.51%Colore e forma:SolidPeso molecolare:366.41CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Formula:C28H30N6O2Purezza:99.61%Colore e forma:SolidPeso molecolare:482.589-Isopropylolomoucine
CAS:9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.Formula:C17H22N6OPurezza:99.82%Colore e forma:SolidPeso molecolare:326.4CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formula:C11H8F3N3OPurezza:98.48%Colore e forma:SolidPeso molecolare:255.2CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Formula:C22H16O5Purezza:99.8%Colore e forma:SolidPeso molecolare:360.36PS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Formula:C25H23F3O9Purezza:98.81% - 99.26%Colore e forma:SolidPeso molecolare:524.44SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formula:C15H18Br2N4Purezza:99.764% - 99.84%Colore e forma:SolidPeso molecolare:414.14hSMG-1 inhibitor 11e
CAS:hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.Formula:C26H27N7O3SPurezza:99.89%Colore e forma:SolidPeso molecolare:517.6HTH-01-091
CAS:HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,Formula:C26H28Cl2N4O2Purezza:98.82%Colore e forma:SolidPeso molecolare:499.43dCeMM2
CAS:dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.Formula:C16H11ClN6OSPurezza:99.68%Colore e forma:SolidPeso molecolare:370.82BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Formula:C14H16N2OSPurezza:99.84%Colore e forma:SolidPeso molecolare:260.35CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formula:C28H30F2N6Purezza:97.25% - 99.72%Colore e forma:SolidPeso molecolare:488.57Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Formula:C27H32F2N8OPurezza:98.1% - 99.08%Colore e forma:SolidPeso molecolare:522.59Ryuvidine
CAS:<p>Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.</p>Formula:C15H12N2O2SPurezza:98.6%Colore e forma:SolidPeso molecolare:284.33EHT 1610
CAS:EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.Formula:C18H14FN5O2SPurezza:98.43%Colore e forma:SolidPeso molecolare:383.4DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formula:C13H17ClO4Purezza:99.57%Colore e forma:SolidPeso molecolare:272.72Cdk2 Inhibitor II
CAS:Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.Formula:C14H11BrN4O3SPurezza:97.27%Colore e forma:SolidPeso molecolare:395.23AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Formula:C21H22F3N5O4Purezza:99.97%Colore e forma:SolidPeso molecolare:465.43(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Formula:C20H27F2N5O4SPurezza:98.59%Colore e forma:SolidPeso molecolare:471.52Cdc7-IN-7c
CAS:<p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>Formula:C15H17N5OSPurezza:98.19% - 99.22%Colore e forma:SolidPeso molecolare:315.39CDK-IN-2
CAS:CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).Formula:C18H19ClFN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:363.81Tacaciclib
CAS:Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].Formula:C30H36N6O3Purezza:98%Colore e forma:SolidPeso molecolare:528.65Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Formula:C26H34N8OPurezza:99%Colore e forma:SolidPeso molecolare:474.6Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Formula:C26H25ClN4O2Purezza:99.23%Colore e forma:SolidPeso molecolare:460.96CDK-IN-11
CAS:CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].Formula:C25H21BrN4O2Colore e forma:SolidPeso molecolare:489.36(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purezza:98%Colore e forma:SolidPeso molecolare:462.32CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Formula:C31H32FN7O3Purezza:99.54%Colore e forma:SolidPeso molecolare:569.63
