Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 281 prodotti di "Microtubulo associato"
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Tubulin polymerization-IN-63
CAS:Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.Formula:C20H24ClCuN5O2SColore e forma:SolidPeso molecolare:497.5TPI-287
CAS:TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.Formula:C46H63NO15Colore e forma:SolidPeso molecolare:869.99Tubulin polymerization-IN-75
CAS:Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.Formula:C14H11NOColore e forma:SolidPeso molecolare:209.243Tau ligand-1
CAS:Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.Formula:C17H16FN3OColore e forma:SolidPeso molecolare:297.327Icafolin-methyl
CAS:Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.Formula:C18H18F2N2O5Colore e forma:SolidPeso molecolare:380.343Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Formula:C30H41NO6SColore e forma:SolidPeso molecolare:543.71Tubulin polymerization-IN-33
Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.Formula:C27H28N2O6Colore e forma:SolidPeso molecolare:476.52Auristatin S
CAS:AuristatinS is a potent anti-tumor agent that serves as an Auristatin payload. It effectively reduces the bystander effect and decreases off-target toxicity. In the Karpas/KarpasBVR cell model, AuristatinS exhibits excellent tolerability. It can be used as the cytotoxic component in antibody-drug conjugates (ADCs) for treating various types of cancer.Formula:C38H65N5O8Colore e forma:SolidPeso molecolare:719.95Tubulin polymerization-IN-74
CAS:Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.Formula:C14H11NSColore e forma:SolidPeso molecolare:225.309Isodienestrol
CAS:Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.Formula:C18H18O2Colore e forma:SolidPeso molecolare:266.33Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purezza:98%Colore e forma:SolidPeso molecolare:643.30Tubulin inhibitor 16
Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Colore e forma:SolidPeso molecolare:269.27Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Formula:C22H18N6OColore e forma:SolidPeso molecolare:382.42JC168
CAS:JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.Formula:C26H40O7Colore e forma:SolidPeso molecolare:464.592Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Formula:C29H30N2O7Colore e forma:SolidPeso molecolare:518.56OXS007417
OXS007417 induces AML cell differentiation at 48 nM EC50 and shows potent in vivo antitumor effects.Formula:C20H14F3N3OColore e forma:SolidPeso molecolare:369.34Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Formula:C21H19N3O3Colore e forma:SolidPeso molecolare:361.39Alfalone
CAS:Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.Formula:C17H14O5Colore e forma:SolidPeso molecolare:298.29TTBK1/2-IN-1
CAS:TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Formula:C17H16N4OColore e forma:SolidPeso molecolare:292.335Symplostatin 1
CAS:Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Formula:C43H70N6O6SColore e forma:SolidPeso molecolare:799.12Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Formula:C32H52O6Colore e forma:SolidPeso molecolare:532.75AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Formula:C20H20N4OColore e forma:SolidPeso molecolare:332.399Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Formula:C21H23NO5Colore e forma:SolidPeso molecolare:369.41Antitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Formula:C19H21FN2O3SeColore e forma:SolidPeso molecolare:423.34Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formula:C20H17BrFNO4Colore e forma:SolidPeso molecolare:434.26Tubulin inhibitor 15
Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Colore e forma:SolidPeso molecolare:269.27Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purezza:98%Colore e forma:SolidPeso molecolare:402.44Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Colore e forma:SolidPeso molecolare:225.63Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Colore e forma:SolidPeso molecolare:264.263Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purezza:98%Colore e forma:SolidPeso molecolare:580.89
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