Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 283 prodotti di "Microtubulo associato"
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MAP4343
CAS:Map4343, a 3-methyl ether pregnenolone derivative, binds MAP2, boosts tubulin polymerization, spurs neurite growth, and guards neurons.Formula:C22H34O2Purezza:97.024%Colore e forma:SolidPeso molecolare:330.5N-Phenylbenzylamine
CAS:A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerizationFormula:C13H13NPurezza:98.75%Colore e forma:Colorless To Pale Yellow Crystalline PowderPeso molecolare:183.25Valecobulin
CAS:Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.Formula:C26H28N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:536.6Vindesine sulfate
CAS:Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.Formula:C43H57N5O11SPurezza:97.51%Colore e forma:Amorphous SolidPeso molecolare:852Tau protein (592-597), Human TFA
Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.Formula:C36H63F3N10O11Purezza:>99.99%Colore e forma:SolidPeso molecolare:868.94Albendazole sulfoxide
CAS:Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.Formula:C12H15N3O3SPurezza:97.29%Colore e forma:White To Off-White PowderPeso molecolare:281.33Clanfenur
CAS:Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.Formula:C16H15ClFN3O2Purezza:99.93%Colore e forma:SolidPeso molecolare:335.76Ref: TM-T5448
1mg37,00€5mg81,00€10mg116,00€25mg188,00€50mg284,00€100mg395,00€200mg560,00€1mL*10mM (DMSO)92,00€Suprafenacine
CAS:<p>Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces</p>Formula:C16H18N4OPurezza:99.91%Colore e forma:SolidPeso molecolare:282.34D-64131
CAS:D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.Formula:C16H13NO2Purezza:99.48% - 99.67%Colore e forma:SolidPeso molecolare:251.28LP-261
CAS:LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.Formula:C22H19N3O4SPurezza:99.91%Colore e forma:SolidPeso molecolare:421.47Ref: TM-T9595
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€1mL*10mM (DMSO)87,00€MMAF
CAS:MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.Formula:C39H65N5O8Purezza:97.00% - 99.88%Colore e forma:SolidPeso molecolare:731.96Plinabulin
CAS:Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).Formula:C19H20N4O2Purezza:98.69% - >99.99%Colore e forma:SolidPeso molecolare:336.39Spastazoline
CAS:Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).Formula:C20H30N8Purezza:99.23%Colore e forma:SolidPeso molecolare:382.51Ref: TM-T8513
1mg35,00€5mg74,00€10mg111,00€25mg215,00€50mg324,00€100mg465,00€200mg645,00€1mL*10mM (DMSO)82,00€Parbendazole
CAS:Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.Formula:C13H17N3O2Purezza:99.60%Colore e forma:Physical Description Crystals Or Fine White Powder (Ntp 1992)Peso molecolare:247.29T807
CAS:T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).Formula:C16H10FN3Purezza:99.72%Colore e forma:SolidPeso molecolare:263.27Ref: TM-T19573
2mg47,00€5mg70,00€10mg107,00€25mg187,00€50mg323,00€100mg550,00€200mg758,00€500mg1.159,00€MMAD
CAS:MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).Formula:C41H66N6O6SPurezza:99.25% - 99.91%Colore e forma:SolidPeso molecolare:771.06Soblidotin
CAS:Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.Formula:C39H67N5O6Purezza:99.89%Colore e forma:SolidPeso molecolare:701.98Curvulin
CAS:Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.Formula:C12H14O5Purezza:98.65%Colore e forma:SolidPeso molecolare:238.24Ref: TM-T36850
1mg145,00€5mg319,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)284,00€Estramustine
CAS:Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.Formula:C23H31Cl2NO3Purezza:98.09%Colore e forma:SolidPeso molecolare:440.4Ref: TM-T20681
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg329,00€200mg487,00€1mL*10mM (DMSO)50,00€NQTrp
CAS:NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.Formula:C21H16N2O4Purezza:98.35%Colore e forma:SolidPeso molecolare:360.36ST-401
CAS:ST-401, a microtubule-targeting agent (MTA), functions as a brain-penetrant microtubule (MT) assembly inhibitor. It disrupts microtubule (MT) function by gently and reversibly reducing MT assembly, which leads to mitotic delay and interphase cell death. ST-401 demonstrates potent antitumor activity.Formula:C24H20N2OColore e forma:SolidPeso molecolare:352.43Semorinemab
CAS:Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease.Purezza:95% - 96.7% (SDS-PAGE); 97.2% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.24 kDa4-Desacetylvinblastine hydrazide
CAS:Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.Formula:C43H56N6O7Colore e forma:SolidPeso molecolare:768.94Gosuranemab
CAS:Gosuranemab (BIIB092) is a humanised monoclonal antibody targeting N-terminal tau, inhibiting the propagation and aggregation of pathological tau protein.Purezza:95% - 97.5% (SDS-PAGE); 95.2% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:144.93 kDaPosdinemab
CAS:<p>Posdinemab, a humanized IgG1κ antibody, targets the microtubule-associated protein tau (MAPT) [1].</p>Colore e forma:LiquidTubulin polymerization-IN-2
CAS:Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.Formula:C17H12F2N2O2Colore e forma:SolidPeso molecolare:314.29Auristatin F
CAS:Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.Formula:C40H67N5O8Purezza:98.41% - 99.25%Colore e forma:SolidPeso molecolare:745.99Hydromethylthionine HBr
CAS:Hydromethylthionine (LMTM/Leucomethylene Blue) inhibits tau in Alzheimer's/frontotemporal dementia and improves brain function.Formula:C16H21Br2N3SColore e forma:SolidPeso molecolare:447.233(S)-Dolaphenine hydrochloride
CAS:(S)-Dolaphenine hydrochloride is a useful componet of compound synthesis.Formula:C11H13ClN2SPurezza:98%Colore e forma:SolidPeso molecolare:240.75Microtubule inhibitor 7
CAS:Compounds 17o and 17p have IC50s of 14.0 nM and 2.9 nM respectively, in NCI-H460 cancer cells, showing potent activity.Formula:C25H19FN2O5Colore e forma:SolidPeso molecolare:446.43(R)-TTBK1-IN-1
CAS:(R)-TTBK1-IN-1: potent, selective brain-penetrant TTBK1 inhibitor, studies Alzheimer’s & tauopathies.Formula:C18H19N5O2Colore e forma:SolidPeso molecolare:337.38Tubulin polymerization-IN-25
CAS:Tubulin polymerization-IN-25 inhibits tubulin (IC50: 1.11 μM) & FTase (IC50: 0.39 μM), and is cytotoxic to cancer cells, halting growth.Formula:C24H18N2O3SColore e forma:SolidPeso molecolare:414.48Tubulin polymerization-IN-15
CAS:Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].Formula:C18H17N3O4Colore e forma:SolidPeso molecolare:339.35Tubulin polymerization-IN-20
CAS:Tubulin aggregation-IN-20, a potent inhibitor, may be studied for breast and drug-resistant colon cancers.Formula:C25H24FNO5Colore e forma:SolidPeso molecolare:437.46Tubulin inhibitor 18
CAS:"Tubulin inhibitor 18 (5j), a potent chalcone, uniquely structured for cancer research."Formula:C22H26O5Colore e forma:SolidPeso molecolare:370.44Tubulin/MMP-IN-1
Tubulin/MMP-IN-1 inhibits tubulin, MMP, and cancer cell growth; disrupts cell cycles and induces apoptosis.Formula:C38H44NO9PColore e forma:SolidPeso molecolare:689.73Synstab A
CAS:Synstab A is a microtubule stabilizer.Formula:C15H13BrCl3N3O3SColore e forma:SolidPeso molecolare:501.61Tubulin inhibitor 12
CAS:New tubulin inhibitor 12 (Hit 9); potent anti-cancer agent; IC50=25.3 μM; strong anti-tumor effect.Formula:C24H20N2OColore e forma:SolidPeso molecolare:352.43Tau tracer 1
CAS:Tau tracer 1 is a radiopharmaceutical for imaging Tau aggregates linked to neurodegenerative disease diagnosis.Formula:C34H23N5O2Colore e forma:SolidPeso molecolare:533.591SB26019
CAS:SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.Formula:C24H20O4Colore e forma:SolidPeso molecolare:372.41Deox B 7,4
CAS:Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.Formula:C18H18O5Colore e forma:SolidPeso molecolare:314.33Tubulin inhibitor 20
CAS:Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].Formula:C19H18O4Colore e forma:SolidPeso molecolare:310.34Tubulin inhibitor 26
CAS:Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.Formula:C17H19N3O3Colore e forma:SolidPeso molecolare:313.35Microtubule inhibitor 5
CAS:Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.Formula:C22H15FN2O4Colore e forma:SolidPeso molecolare:390.36Tubulin polymerization-IN-37
CAS:Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.Formula:C19H20N2O4Colore e forma:SolidPeso molecolare:340.37THK-5117
CAS:THK-5117, a tau PET probe, has a high tau fibril affinity (Ki 10.5 nM) and binds well to AD brain aggregates.Formula:C19H19FN2O2Colore e forma:SolidPeso molecolare:326.36OXi8007
CAS:OXi8007, a water-soluble prodrug for OXi8006, disrupts vasculature and exhibits strong cytotoxicity against DU-145 cancer cells.Formula:C26H24NNa2O10PColore e forma:SolidPeso molecolare:587.428Iso-Fludelone
CAS:Iso-Fludelone: a stable, soluble, potent, 3rd-gen epothilone B inhibiting cell division and inducing apoptosis, with low toxicity.Formula:C27H36F3NO6Colore e forma:SolidPeso molecolare:527.57Tubulin polymerization-IN-18
CAS:Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.Formula:C25H25NO6Colore e forma:SolidPeso molecolare:435.47O-GlcNAcase-IN-4
CAS:O-GlcNAcase-IN-4, an inhibitor from patent WO2018140299A1, may aid in neurodegenerative disease research.Formula:C16H22FN5O3SColore e forma:SolidPeso molecolare:383.44
