Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 283 prodotti di "Microtubulo associato"
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Antitumor agent-68
CAS:Potent Antitumor-68 inhibits tubulin, IC50: 3.6μM HeLa, 3.8μM MCF-7; also scavenges ROS/DPPH dose-dependently.Formula:C17H11NO2Colore e forma:SolidPeso molecolare:261.27Tubulin polymerization-IN-16
CAS:Compound 5g is a potent tubulin aggregation inhibitor, disrupting microtubules and causing G2/M arrest in SGC-7901 cells.Formula:C24H27N5O5Colore e forma:SolidPeso molecolare:465.5Tubulin polymerization-IN-36
CAS:Tubulin polymerization-IN-36, a cancer research agent for lymphomas, inhibits tubulin at the colchicine site with IC50 of 2.8 µM.Formula:C18H18N2O3Colore e forma:SolidPeso molecolare:310.35Antitumor agent-71
CAS:Antitumor Agent-71 inhibits tubulin aggregation; IC50 of 3.98-15.70 μM against cancer cells.Formula:C26H31N5O4SColore e forma:SolidPeso molecolare:509.62Neuroinflammatory-IN-3
CAS:Neuroinflammatory-IN-3 is a potent tubulin inhibitor with anti-neuroinflammatory and antitumor properties.Formula:C19H19ClO3Colore e forma:SolidPeso molecolare:330.81CCB02
CAS:CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity.Formula:C14H9N3OPurezza:98.38%Colore e forma:SolidPeso molecolare:235.24Ref: TM-T10704
1mg77,00€5mg170,00€10mg259,00€25mg507,00€50mg775,00€100mg1.054,00€1mL*10mM (DMSO)182,00€Tubulin polymerization-IN-10
CAS:Tubulin polymerization-IN-10 inhibits tubulin polymerization with 4.25 μM IC50 and has anti-tumor properties.Formula:C18H21NO6SColore e forma:SolidPeso molecolare:379.43S516
CAS:S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.Formula:C21H19N5O4SPurezza:98%Colore e forma:SolidPeso molecolare:437.47Tubulin polymerization-IN-21
CAS:Tubulin polymerization-IN-21 disrupts microtubules, affects glucose metabolism, and has anticancer properties.Formula:C30H29NO7Colore e forma:SolidPeso molecolare:515.55Tubulin inhibitor 27
CAS:DYT-1 Tubulin inhibitor 27, IC50: 25.6 μM, hinders tubulin polymerization, displays anti-angiogenic and antitumor effects.Formula:C21H19NO4Colore e forma:SolidPeso molecolare:349.38Microtubule inhibitor 4
CAS:Microtubule inhibitor 4 (Compound 2) blocks polymerization, toxic to HT-29 cells (IC50: 2.1 nM).Formula:C25H23FN4O3Colore e forma:SolidPeso molecolare:446.47BNC105P
CAS:BNC105P, a prodrug VDA, converts to BNC105, blocks tubulin polymerization, disrupts tumor vessels, and evades P-glycoprotein resistance.Formula:C20H21O10PColore e forma:SolidPeso molecolare:452.3485Tubulin polymerization-IN-29
CAS:Tubulin polymerization-IN-29 inhibits microtubule assembly, has anti-proliferative properties, and arrests HeLa cells at G2/M.Formula:C25H20FNO6Colore e forma:SolidPeso molecolare:449.43isoCA-4
CAS:isoCA-4 is a Combretastatin A4 derivative. isoCA-4 is a tubulin polymerization inhibitor with anti-proliferative activities [1].Formula:C18H20O5Colore e forma:SolidPeso molecolare:316.35IDT
CAS:IDT, an oral TNFα modulator, changes neutrophil levels, boosts cognition, and reduces tau/amyloid in 3xTgAD mice.Formula:C8H5NS2Purezza:98%Colore e forma:SolidPeso molecolare:179.26DHNQ
CAS:DHNQ is a novel inhibitor of the PI3K enzyme activity and transcriptional as well as translational expression levels in colorectal cancer (CRC).Formula:C18H14N2OColore e forma:SolidPeso molecolare:274.32D011-2120
CAS:D011-2120: Antiviral that blocks microtubule growth, disrupts Golgi, and hinders viral egress.Formula:C17H15NO3Purezza:98%Colore e forma:SolidPeso molecolare:281.31DAT1
CAS:DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.Formula:C17H15N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:325.38Acodazole
CAS:Acodazole is a synthetic imidazoquinoline. It has antimicrobial and antineoplastic properties. It also has been shown to treat arrhythmias.Formula:C20H19N5OPurezza:98%Colore e forma:SolidPeso molecolare:345.4Acodazole hydrochloride
CAS:Acodazole hydrochloride: synthetic imidazoquinoline with antineoplastic activity; disrupts DNA replication by intercalation.Formula:C20H20ClN5OPurezza:98%Colore e forma:SolidPeso molecolare:381.86LDN-193665
CAS:LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.Formula:C15H11FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:314.34MG-2119
CAS:MG-2119 is a potent inhibitor of monomeric tau and α-syn aggregation and can be used to study neurological diseases.Formula:C27H29N5O4Colore e forma:SolidPeso molecolare:487.55Aha1/Hsp90-IN-1
CAS:Aha1/Hsp90-IN-1 (Compound 17) inhibits Aha1/Hsp90, preventing tau aggregation; IC50 = 3.32 μM.Formula:C22H17F3N4O2Colore e forma:SolidPeso molecolare:426.39Tubulin polymerization-IN-27
CAS:Compound 5j inhibits tubulin polymerization, arrests cell cycle at G2/M phase, and induces apoptosis.Formula:C22H20N2O2Colore e forma:SolidPeso molecolare:344.41GF 15
CAS:GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.Formula:C23H21ClO6Purezza:98%Colore e forma:SolidPeso molecolare:428.86OSIP-486823
CAS:OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.Formula:C29H28FNO4Purezza:98.59%Colore e forma:SolidPeso molecolare:473.54DJ101
CAS:DJ101: A stable tubulin inhibitor that bypasses multidrug resistance efflux pumps.Formula:C23H20N4O3Purezza:98%Colore e forma:SolidPeso molecolare:400.43Tubulin polymerization-IN-19
CAS:Tubulin aggregation-IN-19 (compound 4) is a potent tubulin aggregation inhibitor that has shown potential in breast cancer and drug-resistant colon cancer.Formula:C25H25NO5Colore e forma:SolidPeso molecolare:419.47Anticancer agent 49
CAS:Anticancer agent 49, also 69, hinders cell growth and microtubule aggregation, with potential in solid and blood cancer research.Formula:C26H25N3O4Colore e forma:SolidPeso molecolare:443.49TOK-8801
CAS:TOK-8801 is a dihydroimidazole thiazole carboxamide with immunomodulatory activity.Formula:C17H21N3OSPurezza:99.97%Colore e forma:SolidPeso molecolare:315.43MT-7
CAS:MT-7 is a tubulin polymerization inhibitor.Formula:C22H17N3O2Purezza:98%Colore e forma:SolidPeso molecolare:355.39Tubulin inhibitor 7
CAS:Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (Formula:C21H14N2O4Purezza:98%Colore e forma:SolidPeso molecolare:358.35Alyssin, (R)-
CAS:Alyssin, (R)-, is an analogue of Sulforaphane that has been shown to have cytotoxic effect on CCRF-SB leukemia cells and lymphoblastoid cells.Formula:C7H13NOS2Colore e forma:SolidPeso molecolare:191.31Cemadotin hydrochloride
CAS:Cemadotin hydrochloride (LU103793) is a synthetic mitosis inhibitor derived from Dolastatin 15 for treating solid tumors.Formula:C35H57ClN6O5Colore e forma:SolidPeso molecolare:677.33Alyssin, (S)-
CAS:Alyssin, (S)-, is an analogue of Sulforaphane that has been shown to have cytotoxic effect on CCRF-SB leukemia cells and lymphoblastoid cells.Formula:C7H13NOS2Colore e forma:SolidPeso molecolare:191.31OX01914
CAS:OX01914 is a soluble modulator to increase utrophin in DMD studies, EC50 20.5 μM.Formula:C17H14N4OColore e forma:SolidPeso molecolare:290.32Denibulin HCl
CAS:Denibulin (MN-029) disrupts tumor blood vessels by inhibiting microtubule assembly, enhancing radiation and cisplatin efficacy.Formula:C18H20ClN5O3SColore e forma:SolidPeso molecolare:421.9Centmitor-1
CAS:Centmitor-1 is a novel mitotic inducer that modulates the positive end of microtubules and reduces microtubule dynamics.Formula:C22H16BrN3O3Colore e forma:SolidPeso molecolare:450.28CAY10701
CAS:CAY10701, a 7-deazahypoxanthine, impedes cell growth (GI50: 9-38 nM) while sparing normal fibroblasts (>1,500-fold), and shrinks mouse colorectal tumors.Formula:C24H19N3O2Colore e forma:SolidPeso molecolare:381.43CHM-1-P-Na
CAS:CHM-1-P-Na is used as a hydrophilic prodrug of CHM-1.Formula:C16H11FNNaO6PColore e forma:SolidPeso molecolare:386.227Tubulin inhibitor 28
CAS:Compound 2g, a tubulin inhibitor with an IC50 of 1.2 μM, inhibits MCF-7 cell proliferation.Formula:C12H8Br2S2Colore e forma:SolidPeso molecolare:376.13Tubulin polymerization-IN-39
Tubulin-IN-39 inhibits polymerization (IC50: 4.9 μM), blocks colchicine site, stops cancer growth.Formula:C21H21N5O5Colore e forma:SolidPeso molecolare:423.42Anticancer agent 48
CAS:Compound 48: broad-spectrum, anti-proliferative, inhibits microtubules, active in vivo, with potential for tumor research.Formula:C26H25N3O4Colore e forma:SolidPeso molecolare:443.49Microtubule inhibitor 1
CAS:Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells).Formula:C21H19NO3Purezza:98%Colore e forma:SolidPeso molecolare:333.38Microtubule inhibitor 3
CAS:Compounds 17o and 17p with furan have IC50s of 14.0 and 2.9 nM, respectively, against NCI-H460 cancer cells.Formula:C26H23FN4O3Colore e forma:SolidPeso molecolare:458.48Amphethinile
CAS:Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.Formula:C15H11N3SPurezza:98%Colore e forma:SolidPeso molecolare:265.33Sirt1/2-IN-1
CAS:Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.Formula:C22H13ClN2OS2Colore e forma:SolidPeso molecolare:420.93Tubulozole
CAS:Tubulozole blocks mitosis by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis.Formula:C23H23Cl2N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:508.42Mivobulin
CAS:Mivobulin is an inhibitor of tubulin .Formula:C17H19N5O2Purezza:98%Colore e forma:SolidPeso molecolare:325.37S-methyl DM1
CAS:S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.Formula:C36H50ClN3O10SPurezza:98%Colore e forma:SolidPeso molecolare:752.31
