Microtubulo associato
Gli inibitori delle proteine associate ai microtubuli prendono di mira le proteine che interagiscono con i microtubuli, i componenti strutturali del citoscheletro della cellula essenziali per la divisione cellulare. Queste proteine regolano la stabilità e la dinamica dei microtubuli durante la mitosi. L'inibizione delle proteine associate ai microtubuli può interrompere la funzione dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi, in particolare nelle cellule tumorali a rapida divisione. Questi inibitori sono ampiamente utilizzati nella ricerca sul cancro e nello sviluppo di farmaci. Presso CymitQuimica, offriamo una gamma completa di inibitori di proteine associate ai microtubuli di alta qualità per supportare la tua ricerca sulla divisione cellulare, la dinamica del citoscheletro e la terapia del cancro.
Trovati 283 prodotti di "Microtubulo associato"
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Alyssin
CAS:Alyssin: sulforaphane analog, antioxidant; boosts Nrf2 and phase II enzymes in cancer cells; lowers PAH metabolism, reducing cancer risk in vitro.Formula:C7H13NOS2Purezza:98%Colore e forma:SolidPeso molecolare:191.31Tubulin polymerization-IN-42
CAS:Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, inhibits tubulin polymerization and exhibits anti-cancer properties [1].Formula:C22H21NO5Colore e forma:SolidPeso molecolare:379.41Cevipabulin
CAS:Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cellFormula:C18H18ClF5N6OPurezza:99.53%Colore e forma:SolidPeso molecolare:464.82IQTub4P
CAS:IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM).Formula:C19H18NNa2O8PColore e forma:SolidPeso molecolare:465.305Tau protein aggregation-IN-1
CAS:Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disordersFormula:C17H11BrN2O2Colore e forma:SolidPeso molecolare:355.19Tau-aggregation and neuroinflammation-IN-1
CAS:Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.Formula:C25H20N2O7Purezza:99.85%Colore e forma:SolidPeso molecolare:460.44Sabeluzole
CAS:Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.Formula:C22H26FN3O2SPurezza:98.51%Colore e forma:SolidPeso molecolare:415.52Microtubule inhibitor 6
CAS:Compound 17o inhibits microtubules, toxic to NCI-H460, BxPC-3, HT-29 cells (IC50: 14.0, 6.6, 7.0 nM), blocks polymerization.Formula:C24H19FN2O5Colore e forma:SolidPeso molecolare:434.42Tubulin inhibitor 29
CAS:Compound 3c, a tubulin inhibitor, blocks assembly at colchicine site with IC50 of 1.2 μM; anti-proliferative IC50 7.5 μM in MCF-7 cells.Formula:C12H8F2O2S2Colore e forma:SolidPeso molecolare:286.32Tubulin inhibitor 31
Tubulin inhibitor 31: potent with 4 µM IC50, anti-proliferative, inhibits HUVEC migration.Formula:C22H19NO2Colore e forma:SolidPeso molecolare:329.39Tubulin polymerization-IN-7
CAS:Tubulin aggregation-IN-7 is a potent tubulin aggregation inhibitor that has shown research potential for cancer diseases.Formula:C28H24N4O6SColore e forma:SolidPeso molecolare:544.58Tubulin polymerization-IN-30
CAS:Compound 6e inhibits tubulin polymerization, disrupts microtubules, halts G2/M phase, and targets HeLa, SGC-7901, A549 with low IC50.Formula:C22H25N5O3Colore e forma:SolidPeso molecolare:407.47Anticancer agent 60
CAS:Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.Formula:C27H33N5O4SColore e forma:SolidPeso molecolare:523.65AMXI-5001
CAS:AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.Formula:C25H20FN5O3Colore e forma:SolidPeso molecolare:457.46LY3372689
CAS:<p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>Formula:C16H22FN5O3SPurezza:99.43% - 99.53%Colore e forma:SolidPeso molecolare:383.44Tubulin inhibitor 8
CAS:<p>Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.</p>Formula:C21H14N2O3Purezza:98.51% - 99.87%Colore e forma:SolidPeso molecolare:342.35JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Formula:C28H27N5O2Purezza:99.58%Colore e forma:SolidPeso molecolare:465.55Ref: TM-T15612
1mg116,00€5mg240,00€10mg358,00€25mg558,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)246,00€Erbulozole
CAS:Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Formula:C24H27N3O5SPurezza:99.88%Colore e forma:SolidPeso molecolare:469.55SB-216
CAS:<p>SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.</p>Formula:C17H18N4O2Purezza:99.70%Colore e forma:SolidPeso molecolare:310.35Rosabulin
CAS:<p>v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.</p>Formula:C22H16N4O2SPurezza:98.06%Colore e forma:SolidPeso molecolare:400.45CID-663143
CAS:CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.Formula:C19H18N4O2SPurezza:99.68% - 99.77%Colore e forma:SolidPeso molecolare:366.44Ref: TM-T23889
1mg52,00€5mg111,00€10mg163,00€25mg235,00€50mg333,00€100mg447,00€200mg592,00€1mL*10mM (DMSO)115,00€TCS 2210
CAS:TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.Formula:C18H17N3O3Purezza:98.62%Colore e forma:SolidPeso molecolare:323.35Ref: TM-T23446
1mg90,00€2mg123,00€5mg182,00€10mg274,00€25mg469,00€50mg643,00€100mg914,00€500mg1.833,00€1mL*10mM (DMSO)187,00€DM1-SMe
CAS:<p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>Formula:C36H50ClN3O10S2Purezza:99.61%Colore e forma:SolidPeso molecolare:784.38Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Formula:C24H25N5O4Colore e forma:SolidPeso molecolare:447.49Valecobulin hydrochloride
CAS:Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Formula:C26H29ClN6O5SPurezza:99.52%Colore e forma:SolidPeso molecolare:573.06Ref: TM-T13278
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)207,00€N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Formula:C20H23NO5Colore e forma:SolidPeso molecolare:357.4Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFormula:C38H65N11O9Colore e forma:SolidPeso molecolare:819.99Anticancer agent 40
CAS:Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).Formula:C25H29NO6Colore e forma:SolidPeso molecolare:439.5THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Formula:C20H21FN2O2Colore e forma:SolidPeso molecolare:340.39Tubulin polymerization-IN-52
CAS:Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].Formula:C21H18F3N5O3Colore e forma:SolidPeso molecolare:445.39JG-23
CAS:JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) ofFormula:C19H16ClN3OS2Colore e forma:SolidPeso molecolare:401.93ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Formula:C17H21N5O3SColore e forma:SolidPeso molecolare:375.45MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Formula:C16H11FN4Purezza:98%Colore e forma:SolidPeso molecolare:278.28Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Formula:C45H47NO13Colore e forma:SolidPeso molecolare:809.85CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Formula:C25H21N3O2Colore e forma:SolidPeso molecolare:395.453,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Formula:C16H16O4Colore e forma:SolidPeso molecolare:272.3Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Formula:C43H70N6O7SColore e forma:SolidPeso molecolare:815.12PBB3
CAS:PBB3 is a tau-specific PET tracer.Formula:C17H15N3OSColore e forma:SolidPeso molecolare:309.39Tubulin inhibitor 25
CAS:Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.Formula:C26H22O8Colore e forma:SolidPeso molecolare:462.45Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purezza:98%Colore e forma:SolidPeso molecolare:643.30Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SPeso molecolare:517.63PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formula:C37H39N5O9SPeso molecolare:729.80PM-060184
CAS:PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.Formula:C31H45N3O7Purezza:98%Colore e forma:SolidPeso molecolare:571.7Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Formula:C29H30N2O7Colore e forma:SolidPeso molecolare:518.56Tubulin polymerization-IN-8
CAS:Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Formula:C21H24N4O4SColore e forma:SolidPeso molecolare:428.5Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Formula:C22H18N6OColore e forma:SolidPeso molecolare:382.42Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Formula:C21H19N3O3Colore e forma:SolidPeso molecolare:361.39OXS007417
OXS007417 induces AML cell differentiation at 48 nM EC50 and shows potent in vivo antitumor effects.Formula:C20H14F3N3OColore e forma:SolidPeso molecolare:369.34Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFormula:C26H39NO7SColore e forma:SolidPeso molecolare:509.66
