c-Myc
Gli inibitori di c-Myc prendono di mira la proteina c-Myc, un fattore di trascrizione che svolge un ruolo cruciale nella crescita cellulare, proliferazione e apoptosi. c-Myc regola l'espressione di numerosi geni coinvolti nel ciclo cellulare ed è spesso sovraespresso in vari tipi di cancro, portando a una proliferazione cellulare incontrollata e alla crescita tumorale. L'inibizione di c-Myc può interrompere questi processi, inducendo l'arresto del ciclo cellulare e l'apoptosi nelle cellule tumorali. Gli inibitori di c-Myc sono strumenti importanti nella ricerca sul cancro e nello sviluppo terapeutico. Presso CymitQuimica, offriamo una vasta gamma di inibitori di c-Myc di alta qualità per supportare la tua ricerca in oncologia, regolazione del ciclo cellulare e controllo trascrizionale.
Trovati 76 prodotti di "c-Myc"
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VGN50
VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.Formula:C121H218N46O32Peso molecolare:2827.68453c-Myc inhibitor 13
<p>c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.</p>Formula:C30H39N9OPeso molecolare:541.32776Cotylenin A
CAS:Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.Formula:C33H50O11Colore e forma:SolidPeso molecolare:622.744H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formula:C45H45ClFN5O8Colore e forma:SolidPeso molecolare:838.319VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Colore e forma:Odour LiquidPROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Formula:C51H64F2N10O5SColore e forma:SolidPeso molecolare:967.18KL4-219A
<p>KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .</p>Formula:C20H24N2O2SPurezza:99.68%Colore e forma:SolidPeso molecolare:356.48VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formula:C16H12F6N2SPurezza:99.98%Colore e forma:SolidPeso molecolare:378.34CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Formula:C48H50F9N7O7SColore e forma:SolidPeso molecolare:1040WBC100
CAS:<p>WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway</p>Formula:C25H33NO7Purezza:98%Colore e forma:SolidPeso molecolare:459.53c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Formula:C22H24N6OPurezza:98%Colore e forma:SolidPeso molecolare:388.47c-Myc inhibitor 11
c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50 : 6.4), exhibits high clearance, a moderate volume of distribution, and a short half-life in ratFormula:C20H22N6OPurezza:98%Colore e forma:SolidPeso molecolare:362.43MDEG-541
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].Formula:C35H38N4O7SPurezza:98%Colore e forma:SolidPeso molecolare:658.76IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Formula:C13H11Cl2NO4Purezza:99.89%Colore e forma:SolidPeso molecolare:316.14sAJM589
CAS:sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formula:C16H10N2OPurezza:98%Colore e forma:SolidPeso molecolare:246.26Lusianthridin
CAS:Lusianthridin is a natural product from Dendrobium venustum.Formula:C15H14O3Purezza:98.49%Colore e forma:SolidPeso molecolare:242.27Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formula:C37H46O12Purezza:99.06% - ≥95%Colore e forma:SolidPeso molecolare:682.7510058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Formula:C12H11NOS2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:249.35ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Formula:C19H18N4O4Purezza:98.47%Colore e forma:SolidPeso molecolare:366.37EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Formula:C25H24N2O4Purezza:98.51%Colore e forma:SolidPeso molecolare:416.47
