PLK
Gli inibitori delle chinasi Polo-like (PLK) prendono di mira le PLK, una famiglia di chinasi serina/treonina essenziali per varie fasi della divisione cellulare, tra cui l'ingresso in mitosi, l'assemblaggio del fuso e la citocinesi. Le PLK sono fondamentali per la corretta esecuzione del ciclo cellulare e la loro disregolazione è spesso associata al cancro. L'inibizione delle PLK può indurre l'arresto del ciclo cellulare e l'apoptosi nelle cellule tumorali, rendendo questi inibitori strumenti importanti nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle PLK di alta qualità per supportare la tua ricerca sulla mitosi, il controllo del ciclo cellulare e l'oncologia.
Trovati 25 prodotti di "PLK"
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SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Formula:C40H40F2N12O5Purezza:98%Colore e forma:SolidPeso molecolare:806.82RP-1664
CAS:<p>RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.</p>Formula:C23H24F2N8O2SPurezza:99.04%Colore e forma:SoildPeso molecolare:514.55PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Colore e forma:Odour SolidPLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Colore e forma:Odour SolidPLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS:Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.Formula:C10H13NO2Purezza:98%Colore e forma:SolidPeso molecolare:179.22PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Purezza:96.8%Colore e forma:Lyophilized PowderPeso molecolare:70.5 kDa (predicted); 66 kDa (reducing conditions)5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formula:C8H13N3SPurezza:99.03%Colore e forma:SolidPeso molecolare:183.27MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formula:C24H25F3N6SPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:486.56GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurezza:99% - 99.73%Colore e forma:SolidPeso molecolare:543.6HMN-176
CAS:<p>HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).</p>Formula:C20H18N2O4SPurezza:98.92% - 98.99%Colore e forma:SolidPeso molecolare:382.43(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formula:C29H30Cl2N6O2Purezza:97.08%Colore e forma:SolidPeso molecolare:565.5Poloxin
CAS:<p>Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).</p>Formula:C18H19NO3Purezza:99.19%Colore e forma:SolidPeso molecolare:297.35HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formula:C22H20N2O5SPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:424.47TAK-960
CAS:<p>TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.</p>Formula:C27H34F3N7O3Purezza:97.06%Colore e forma:SolidPeso molecolare:561.6Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formula:C27H35F2N7O3Purezza:97.1% - >99.99%Colore e forma:SolidPeso molecolare:543.61Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purezza:98.71%Colore e forma:SolidPeso molecolare:631.67Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formula:C9H4F3N3O4SPurezza:99.64%Colore e forma:SolidPeso molecolare:307.21Poloxin-2
CAS:<p>Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.</p>Formula:C16H15NO3Purezza:99.67%Colore e forma:SolidPeso molecolare:269.3TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formula:C21H17N3O3Purezza:99.516%Colore e forma:SolidPeso molecolare:359.38
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