DYRK
Gli inibitori delle chinasi DYRK (chinasi regolata dalla fosforilazione della tirosina a doppia specificità) sono composti che prendono di mira la famiglia di chinasi DYRK, coinvolte nella regolazione del ciclo cellulare, nello sviluppo neuronale e nell'apoptosi. Le chinasi DYRK hanno doppia specificità, il che significa che possono fosforilare sia residui di tirosina che di serina/treonina. L'inibizione delle chinasi DYRK può influenzare vari processi cellulari, inclusi la progressione del ciclo cellulare e la differenziazione. Gli inibitori DYRK sono strumenti importanti nella ricerca sul cancro, sulle malattie neurodegenerative e sulla segnalazione cellulare. Presso CymitQuimica, offriamo una selezione di inibitori DYRK di alta qualità per supportare la tua ricerca nel controllo del ciclo cellulare, nella neurobiologia e nello sviluppo terapeutico.
Trovati 49 prodotti di "DYRK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
BT173
CAS:BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.Formula:C18H12BrN3O2Purezza:98.247%Colore e forma:SolidPeso molecolare:382.21AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Formula:C19H16N4Purezza:99.91%Colore e forma:SolidPeso molecolare:300.36GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Formula:C18H10Cl2N4OSPurezza:98.27%Colore e forma:SolidPeso molecolare:401.27Leucettine L41
CAS:Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.Formula:C17H13N3O3Purezza:99.08%Colore e forma:SolidPeso molecolare:307.3GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Formula:C24H30N6O2Purezza:98.51%Colore e forma:SolidPeso molecolare:434.53CLK1-IN-3
CAS:Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.Formula:C24H23FN6OPurezza:98.46% - 99.76%Colore e forma:SoildPeso molecolare:430.48Protein kinase inhibitors 1 hydrochloride
CAS:Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,Formula:C18H18ClN5O3SColore e forma:SolidPeso molecolare:419.88Mirk-IN-1
CAS:Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).Formula:C23H17Cl2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:498.32LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Formula:C18H22Cl2N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:401.35Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Formula:C13H12N2OPurezza:98.29% - 99.92%Colore e forma:Off-White SolidPeso molecolare:212.25Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Formula:C18H17N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:383.42GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formula:C25H27FN6O4Purezza:98.68% - 99.40%Colore e forma:SolidPeso molecolare:494.52Harmine hydrochloride
CAS:Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.Formula:C13H13ClN2OPurezza:99.61% - >99.99%Colore e forma:Yellow To Slightly Green Crystalline PowderPeso molecolare:248.71LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Formula:C18H20N2O2SPurezza:99.01% - 99.51%Colore e forma:SolidPeso molecolare:328.43AZ191
CAS:AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.Formula:C24H27N7OPurezza:98.04% - 99.65%Colore e forma:SolidPeso molecolare:429.52ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:232.24GNF2133 hydrochloride
CAS:GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Formula:C24H31ClN6O2Colore e forma:SolidPeso molecolare:471.02-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Formula:C6H6N4OPurezza:99.21% - 99.42%Colore e forma:SolidPeso molecolare:150.14ML167
CAS:<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Formula:C19H17N3O3Purezza:99.82% - >99.99%Colore e forma:SolidPeso molecolare:335.36ID-8
CAS:<p>ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.</p>Formula:C16H14N2O4Purezza:99.32%Colore e forma:SolidPeso molecolare:298.29DYRKi
CAS:DYRKi is a nontoxic, DYRK1-selective inhibitor.Formula:C20H13F3N4O2SColore e forma:SolidPeso molecolare:430.4LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Formula:C17H19Cl3N2OSColore e forma:SolidPeso molecolare:405.77Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Formula:C16H9IN2O2Colore e forma:SolidPeso molecolare:388.16Dyrk1A-IN-3
CAS:Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.Formula:C18H16N6Colore e forma:SolidPeso molecolare:316.36tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Formula:C11H3Br4N3O2Purezza:98%Colore e forma:SolidPeso molecolare:528.78AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFormula:C15H13N3OPurezza:99.99%Colore e forma:SolidPeso molecolare:251.28JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Formula:C21H17F3N8OColore e forma:SolidPeso molecolare:454.41FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Formula:C16H17NO2S2SiColore e forma:SolidPeso molecolare:347.53ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Formula:C14H15NO3SPurezza:97.19%Colore e forma:SolidPeso molecolare:277.34INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Formula:C12H13NO2SPurezza:99.26%Colore e forma:SolidPeso molecolare:235.3CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Formula:C28H30N6O2Purezza:99.61%Colore e forma:SolidPeso molecolare:482.58ARN25068
CAS:ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Formula:C19H18N6SPurezza:99.75%Colore e forma:SolidPeso molecolare:362.45YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Formula:C25H27FN8OSPurezza:98.61% - 99.64%Colore e forma:SolidPeso molecolare:506.6ML 315
CAS:ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.Formula:C18H13Cl2N3O2Purezza:99.08%Colore e forma:SolidPeso molecolare:374.22DYRKs-IN-2
CAS:DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Formula:C32H38ClN9O3Purezza:98%Colore e forma:SolidPeso molecolare:632.16Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formula:C17H21N3OColore e forma:SolidPeso molecolare:283.37DYRKs-IN-1
CAS:<p>DYRKs-IN-1 has antitumor activity.</p>Formula:C30H30ClN7O4Purezza:98%Colore e forma:SolidPeso molecolare:588.06DYRKs-IN-1 hydrochloride
CAS:DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formula:C30H31Cl2N7O4Colore e forma:SolidPeso molecolare:624.52Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Formula:C27H32N6O4Colore e forma:SolidPeso molecolare:504.58Norharmine
CAS:Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.Formula:C12H10N2OColore e forma:SolidPeso molecolare:198.221Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Formula:C20H21N5O3SColore e forma:SolidPeso molecolare:411.48Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formula:C14H13F3N6Colore e forma:SolidPeso molecolare:322.29Dyrk1A/α-synuclein-IN-2
<p>Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).</p>Formula:C21H16N4O4SColore e forma:SolidPeso molecolare:420.44DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Formula:C23H24FN7Colore e forma:SolidPeso molecolare:417.48Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Formula:C23H23F5N8OColore e forma:SolidPeso molecolare:522.47Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.Formula:C23H20N4O3SColore e forma:SolidPeso molecolare:432.49Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Formula:C21H17N3O2S2Colore e forma:SolidPeso molecolare:407.51Dyrk1A-IN-12
CAS:<p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>Formula:C22H16FN3O2SColore e forma:SolidPeso molecolare:405.445DYRK1-IN-1
CAS:DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formula:C12H12N6Colore e forma:SolidPeso molecolare:240.26
![2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT5445.webp&w=3840&q=75)
