HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purezza:95.32% - 99.67%Colore e forma:SolidPeso molecolare:505.56Ref: TM-TQ0131
1mg197,00€5mg434,00€10mg748,00€25mg1.459,00€50mg2.483,00€500µg163,00€1mL*10mM (DMSO)474,00€Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formula:C32H48N4O8·HClPurezza:99.94%Colore e forma:SolidPeso molecolare:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurezza:99% - 99.46%Colore e forma:SolidPeso molecolare:617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Formula:C23H38OPurezza:99.1% - 99.96%Colore e forma:SolidPeso molecolare:330.55DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formula:C25H29N5O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:495.59Ref: TM-T9202
1mg37,00€5mg80,00€10mg126,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)88,00€NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purezza:98.03% - 99.32%Colore e forma:SolidPeso molecolare:379.39Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formula:C24H30O9Purezza:98.82% - 99.22%Colore e forma:SolidPeso molecolare:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formula:C22H28N2O2Purezza:97.02%Colore e forma:SolidPeso molecolare:352.47Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formula:C23H28O11Purezza:96.9% - 97.43%Colore e forma:White Fine PowderPeso molecolare:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21ClN4OColore e forma:SolidPeso molecolare:296.8Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purezza:99.64% - 99.68%Colore e forma:SolidPeso molecolare:482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formula:C20H20N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:364.4Ref: TM-T2309
5mg66,00€10mg87,00€25mg133,00€50mg166,00€100mg250,00€200mg424,00€500mg702,00€1mL*10mM (DMSO)74,00€TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Formula:C25H31N5O4Purezza:98.79%Colore e forma:SolidPeso molecolare:465.54KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formula:C13H12N6O2Purezza:97.25% - 99.91%Colore e forma:SolidPeso molecolare:284.27Ref: TM-T3652
5mg51,00€10mg77,00€25mg159,00€50mg263,00€100mg510,00€200mg717,00€500mg1.093,00€1mL*10mM (DMSO)52,00€Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formula:C25H26N8OPurezza:99.22% - 99.49%Colore e forma:SolidPeso molecolare:454.53VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purezza:99.36% - 99.99%Colore e forma:SolidPeso molecolare:387.82Ref: TM-T3454
2mg46,00€5mg64,00€10mg92,00€25mg164,00€50mg259,00€100mg354,00€200mg500,00€1mL*10mM (DMSO)52,00€VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurezza:97.31% - 99.85%Colore e forma:SolidPeso molecolare:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purezza:97.03% - 99.55%Colore e forma:SolidPeso molecolare:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Formula:C18H19N5SPurezza:99.13%Colore e forma:SolidPeso molecolare:337.44HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Formula:C24H28N6O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:464.58
