HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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CH5015765
CAS:CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.Formula:C16H13ClN4OSColore e forma:SolidPeso molecolare:344.82YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Formula:C27H27N3O4S3Colore e forma:SolidPeso molecolare:553.72Grp94-IN-2
CAS:Grp94-IN-2 is a inhibitor of Grp94.Formula:C22H23ClN2O5Colore e forma:SolidPeso molecolare:430.88BF844
CAS:BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.Formula:C21H19ClN4OColore e forma:SolidPeso molecolare:378.85HSP90-IN-12
CAS:VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.Formula:C25H36O4Colore e forma:SolidPeso molecolare:400.55Hsp90-IN-15
CAS:Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.Formula:C23H27F3N4Colore e forma:SolidPeso molecolare:416.48MPC-3100
CAS:MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].Formula:C22H25BrN6O4SColore e forma:SolidPeso molecolare:549.44Retaspimycin Hydrochloride
CAS:Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).Formula:C31H46ClN3O8Purezza:98%Colore e forma:SolidPeso molecolare:624.17HSP90-IN-22
CAS:HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFormula:C25H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:434.53Retaspimycin
CAS:Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).Formula:C31H45N3O8Purezza:98%Colore e forma:SolidPeso molecolare:587.7KUNB31
CAS:KUNB31 is a potent and selective inhibitor of Hsp90β.Formula:C19H18N2O3Colore e forma:SolidPeso molecolare:322.36HSP90-IN-20
CAS:HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.Formula:C26H32N4O4Colore e forma:SolidPeso molecolare:464.56BIIB028
CAS:BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.Formula:C19H21ClN5O5PColore e forma:SolidPeso molecolare:465.83Heat Shock Protein Inhibitor II
CAS:Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.Formula:C12H11NO3Colore e forma:SolidPeso molecolare:217.22YM-1
CAS:YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.Formula:C20H20ClN3OS2Colore e forma:SolidPeso molecolare:417.98SW02
CAS:SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Formula:C19H23BrN2O5Colore e forma:SolidPeso molecolare:439.3PU24FCl
CAS:PU24FCl is a specific inhibitor of tumor Hsp90.Formula:C20H21ClFN5O3Colore e forma:SolidPeso molecolare:433.86BMS-358233
CAS:BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.Formula:C25H25ClN6O2SColore e forma:SolidPeso molecolare:509.02Vibsanin A
CAS:Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.Formula:C25H38O4Colore e forma:SolidPeso molecolare:402.57Hsp90-Cdc37-IN-1
CAS:Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.Formula:C43H57FN2O6SPurezza:98%Colore e forma:SolidPeso molecolare:748.99
