HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formula:C46H62N4O11Purezza:98.87% - 99.7%Colore e forma:Red-Violet Crystalline PowderPeso molecolare:847Ethoxyquin
CAS:<p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>Formula:C14H19NOPurezza:97.15% - 98.73%Colore e forma:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecolare:217.31Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formula:C18H24ClN3O7Purezza:99.44% - 99.98%Colore e forma:SolidPeso molecolare:429.85Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Formula:C31H35N2NaO11Purezza:99% - 99.51%Colore e forma:SolidPeso molecolare:634.61IPI-493
CAS:IPI-493 is a bioactive chemical.Formula:C28H39N3O8Purezza:>99.99%Colore e forma:SolidPeso molecolare:545.62Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formula:C14H11NO4Purezza:99.03% - 99.96%Colore e forma:SolidPeso molecolare:257.24Ref: TM-T10860
2mg47,00€5mg70,00€10mg107,00€25mg216,00€50mg350,00€100mg542,00€200mg778,00€500mg1.169,00€1mL*10mM (DMSO)70,00€GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formula:C17H18N4O2SPurezza:99.49%Colore e forma:SoildPeso molecolare:342.42CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formula:C22H20ClN5O3SPurezza:99.59%Colore e forma:SolidPeso molecolare:469.94HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formula:C22H24N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:444.5MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Formula:C54H66N4O10Colore e forma:SolidPeso molecolare:931.12HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Formula:C37H45N7O5S3Colore e forma:SolidPeso molecolare:763.99Grp94 Inhibitor-3
Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.Formula:C24H20ClNO4Colore e forma:SolidPeso molecolare:421.87TRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Formula:C45H39F7N2O4P2Purezza:98%Colore e forma:SolidPeso molecolare:866.74MPC-0767
CAS:<p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>Formula:C26H36BrN7O9S2Colore e forma:SolidPeso molecolare:734.64Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purezza:98%Colore e forma:Off-White To Fawn SolidPeso molecolare:710.8717-DMAP-GA
CAS:17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.Formula:C33H50N4O8Colore e forma:SolidPeso molecolare:630.783Arimoclomol citrate
CAS:Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.Formula:C20H28ClN3O10Colore e forma:SolidPeso molecolare:505.91Hsp70-derived octapeptide
CAS:TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.Formula:C36H58N8O16Purezza:98%Colore e forma:SolidPeso molecolare:858.89NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormula:C28H32N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:476.63PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Formula:C43H50N6O7Purezza:98%Colore e forma:SolidPeso molecolare:762.89TRAP1-IN-2
CAS:<p>TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.</p>Formula:C46H42F6N2O5P2Purezza:98%Colore e forma:SolidPeso molecolare:878.77Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Formula:C52H65N3O8PPurezza:98%Colore e forma:SolidPeso molecolare:891.078NDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Formula:C31H35F3N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:604.68Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Purezza:98%Colore e forma:Odour Solid3-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formula:C13H11N5O2Purezza:99.88%Colore e forma:SolidPeso molecolare:269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formula:C13H9BrClN5O2Purezza:99.37%Colore e forma:SolidPeso molecolare:382.6Ref: TM-T27193
1mg185,00€5mg409,00€10mg605,00€25mg938,00€50mg1.293,00€100mg1.738,00€500mg3.496,00€1mL*10mM (DMSO)406,00€Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purezza:98%Colore e forma:SolidPeso molecolare:668.81Hsp90-IN-36
Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.Formula:C20H13F4N3O4Colore e forma:SolidPeso molecolare:435.328dPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Colore e forma:Odour SolidA17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Formula:C76H105N19O20SColore e forma:SolidPeso molecolare:1636.83p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Formula:C44H81N15O11SPurezza:98%Colore e forma:SolidPeso molecolare:1028.27HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Colore e forma:SolidPeso molecolare:1062.27PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Formula:C32H29ClN8O5Colore e forma:SolidPeso molecolare:641.08HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formula:C29H48O10Purezza:98%Colore e forma:SolidPeso molecolare:556.69Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Colore e forma:SolidPeso molecolare:481.43PAR4 antagonist 7
PAR4 antagonist7 (Compound 20f) is a selective PAR4 antagonist (IC50: 1.72 nM), effective in inhibiting platelet aggregation induced by PAR4 agonists. It exhibits good metabolic stability and has not shown any tendency to cause bleeding in mice.Formula:C28H20FN5O4SPeso molecolare:541.55HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Formula:C52H60N6O12SPurezza:97.09%Colore e forma:SolidPeso molecolare:993.13Ref: TM-T18018
1mg90,00€5mg215,00€10mg344,00€25mg612,00€50mg848,00€100mg1.159,00€1mL*10mM (DMSO)378,00€Neoantimycin
CAS:Neoantimycin: S. orinoci antibiotic, mild antifungal, like antimycin, from different Streptomyces, biosynthesis known, active variants found.Formula:C36H46N2O12Colore e forma:SolidPeso molecolare:698.7666BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Formula:C45H47Br2N2O3PColore e forma:SolidPeso molecolare:854.65Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formula:C41H64N12O12SPurezza:98%Colore e forma:SolidPeso molecolare:949.09JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Formula:C20H22ClN3OS3Colore e forma:SolidPeso molecolare:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formula:C16H18O5Colore e forma:SolidPeso molecolare:290.315HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidNMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formula:C22H22N4O7Purezza:99.84%Colore e forma:SolidPeso molecolare:454.43Ref: TM-T6609
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg310,00€100mg442,00€200mg622,00€1mL*10mM (DMSO)70,00€HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formula:C27H33N5O5Colore e forma:SolidPeso molecolare:507.58Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Colore e forma:SolidPeso molecolare:730.34008NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formula:C32H32FN5O4Purezza:99.29%Colore e forma:SolidPeso molecolare:569.63Ref: TM-T9804
1mg96,00€5mg240,00€10mg375,00€25mg627,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)300,00€Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurezza:98.98%Colore e forma:SolidPeso molecolare:442.58PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurezza:98.31% - 99.937%Colore e forma:SolidPeso molecolare:512.37Palmitic acid-1-13C
CAS:Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.Formula:C16H32O2Colore e forma:SolidPeso molecolare:257.422CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Formula:C27H23N3O4Colore e forma:SolidPeso molecolare:453.49Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formula:C16H32O2Purezza:99.17% - 99.67%Colore e forma:White Crystalline Scales SolidPeso molecolare:256.42Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Formula:C31H43N3O8Purezza:98.24% - 99.83%Colore e forma:Dark Purple SolidPeso molecolare:585.69PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Formula:C25H30F3N5O4Purezza:99.04%Colore e forma:SolidPeso molecolare:521.53Ref: TM-T6341
1mg39,00€2mg49,00€5mg84,00€10mg119,00€25mg187,00€50mg354,00€100mg527,00€1mL*10mM (DMSO)96,00€L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formula:C8H15N3O4Purezza:99.71% - 99.97%Colore e forma:SolidPeso molecolare:217.22Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurezza:99.33% - 99.79%Colore e forma:SolidPeso molecolare:181.21Apoptozole
CAS:Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Formula:C33H25F6N3O3Purezza:99.75%Colore e forma:SolidPeso molecolare:625.56Ref: TM-T3293
2mg35,00€5mg50,00€10mg84,00€25mg137,00€50mg235,00€100mg349,00€200mg515,00€1mL*10mM (DMSO)66,00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Formula:C29H40N2O9Purezza:97.59% - 99.27%Colore e forma:Yellow To Orange PowderPeso molecolare:560.64TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formula:C25H32ClN5O4Purezza:97.55%Colore e forma:SolidPeso molecolare:502.01Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purezza:93.77%Colore e forma:SolidPeso molecolare:337.37BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurezza:98% - 99.82%Colore e forma:SolidPeso molecolare:318.76Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Formula:C17H24O11Purezza:99.85%Colore e forma:SolidPeso molecolare:404.37Ref: TM-TQ0280
1mg78,00€5mg170,00€10mg274,00€25mg465,00€50mg663,00€100mg919,00€200mg1.216,00€1mL*10mM (DMSO)202,00€HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purezza:99.77% - 99.86%Colore e forma:SolidPeso molecolare:466.58Ref: TM-T6855
1mg35,00€2mg48,00€5mg72,00€10mg96,00€25mg187,00€50mg283,00€100mg439,00€1mL*10mM (DMSO)74,00€VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formula:C19H18ClN3O4Purezza:98.95% - >99.99%Colore e forma:SolidPeso molecolare:387.82Ref: TM-T2268
1mg60,00€2mg85,00€5mg111,00€10mg167,00€25mg283,00€50mg472,00€100mg643,00€1mL*10mM (DMSO)96,00€KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purezza:98.90%Colore e forma:SolidPeso molecolare:245.23Ref: TM-T2444
2mg40,00€5mg57,00€10mg81,00€25mg158,00€50mg233,00€100mg349,00€200mg560,00€1mL*10mM (DMSO)63,00€DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purezza:98.86% - 99.29%Colore e forma:SolidPeso molecolare:309.68Ref: TM-T8858
1mg35,00€5mg70,00€10mg104,00€25mg210,00€50mg338,00€100mg540,00€500mg1.130,00€1mL*10mM (DMSO)78,00€Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFormula:C28H34O5Purezza:99.52%Colore e forma:SolidPeso molecolare:450.57Ref: TM-TN6729
1mg131,00€5mg286,00€10mg515,00€25mg777,00€50mg1.074,00€100mg1.454,00€1mL*10mM (DMSO)354,00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purezza:98.89%Colore e forma:SolidPeso molecolare:409.52Ref: TM-T4125
1mg55,00€2mg88,00€5mg139,00€10mg207,00€25mg462,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)130,00€YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purezza:97.25%Colore e forma:SolidPeso molecolare:398.84Ref: TM-T8901
1mg48,00€5mg96,00€10mg135,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)96,00€KBU2046
CAS:KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.Formula:C15H11FO2Purezza:99.89%Colore e forma:SolidPeso molecolare:242.24Ref: TM-T15646
2mg34,00€5mg52,00€10mg74,00€25mg140,00€50mg212,00€100mg321,00€200mg449,00€1mL*10mM (DMSO)52,00€KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Formula:C30H42N2O9Purezza:98.68% - 99.52%Colore e forma:SolidPeso molecolare:574.66Ref: TM-T6558
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg662,00€1mL*10mM (DMSO)205,00€MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purezza:97.32%Colore e forma:SolidPeso molecolare:509.43XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formula:C29H37N5O3Purezza:99.18%Colore e forma:SolidPeso molecolare:503.64HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Formula:C26H30Cl4N4O2Colore e forma:SolidPeso molecolare:572.35MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Formula:C12H8FN3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:293.27Ref: TM-T8741
1mg70,00€5mg153,00€10mg216,00€25mg369,00€50mg528,00€100mg740,00€200mg1.008,00€500µg48,00€1mL*10mM (DMSO)143,00€MK2-IN-1
CAS:MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.Formula:C27H25ClN4O2Colore e forma:SolidPeso molecolare:472.97HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormula:C13H12O4SPurezza:99.51%Colore e forma:SolidPeso molecolare:264.3Ref: TM-T7265
1mg130,00€2mg185,00€5mg311,00€10mg472,00€25mg753,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)455,00€2-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purezza:98%Colore e forma:SolidPeso molecolare:182.26Luminespib
CAS:<p>Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C26H31N3O5Purezza:98% - 99.25%Colore e forma:SolidPeso molecolare:465.54Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formula:C24H31N3O3Purezza:99.01% - 99.66%Colore e forma:SolidPeso molecolare:409.52Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purezza:95.32% - 99.67%Colore e forma:SolidPeso molecolare:505.56Ref: TM-TQ0131
1mg197,00€5mg434,00€10mg748,00€25mg1.459,00€50mg2.483,00€500µg163,00€1mL*10mM (DMSO)474,00€Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formula:C32H48N4O8·HClPurezza:99.94%Colore e forma:SolidPeso molecolare:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurezza:99% - 99.46%Colore e forma:SolidPeso molecolare:617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Formula:C23H38OPurezza:99.1% - 99.96%Colore e forma:SolidPeso molecolare:330.55DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formula:C25H29N5O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:495.59Ref: TM-T9202
1mg37,00€5mg80,00€10mg126,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)88,00€NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purezza:98.03% - 99.32%Colore e forma:SolidPeso molecolare:379.39Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formula:C24H30O9Purezza:98.82% - 99.22%Colore e forma:SolidPeso molecolare:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formula:C22H28N2O2Purezza:97.02%Colore e forma:SolidPeso molecolare:352.47Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formula:C23H28O11Purezza:96.9% - 97.43%Colore e forma:White Fine PowderPeso molecolare:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21ClN4OColore e forma:SolidPeso molecolare:296.8Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purezza:99.64% - 99.68%Colore e forma:SolidPeso molecolare:482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formula:C20H20N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:364.4Ref: TM-T2309
5mg66,00€10mg87,00€25mg133,00€50mg166,00€100mg250,00€200mg424,00€500mg702,00€1mL*10mM (DMSO)74,00€TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Formula:C25H31N5O4Purezza:98.79%Colore e forma:SolidPeso molecolare:465.54KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formula:C13H12N6O2Purezza:97.25% - 99.91%Colore e forma:SolidPeso molecolare:284.27Ref: TM-T3652
5mg51,00€10mg77,00€25mg159,00€50mg263,00€100mg510,00€200mg717,00€500mg1.093,00€1mL*10mM (DMSO)52,00€Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formula:C25H26N8OPurezza:99.22% - 99.49%Colore e forma:SolidPeso molecolare:454.53VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purezza:99.36% - 99.99%Colore e forma:SolidPeso molecolare:387.82Ref: TM-T3454
2mg46,00€5mg64,00€10mg92,00€25mg164,00€50mg259,00€100mg354,00€200mg500,00€1mL*10mM (DMSO)52,00€VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurezza:97.31% - 99.85%Colore e forma:SolidPeso molecolare:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purezza:97.03% - 99.55%Colore e forma:SolidPeso molecolare:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Formula:C18H19N5SPurezza:99.13%Colore e forma:SolidPeso molecolare:337.44HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Formula:C24H28N6O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:464.58HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Formula:C26H27ClN4O2Purezza:97.15%Colore e forma:SolidPeso molecolare:462.97VER-50589
CAS:VER-50589 is a potent HSP90 inhibitor.Formula:C19H17ClN2O5Purezza:99.96% - >99.99%Colore e forma:SolidPeso molecolare:388.8Ref: TM-T2258
1mg42,00€5mg97,00€10mg159,00€25mg264,00€50mg404,00€100mg588,00€200mg832,00€1mL*10mM (DMSO)97,00€MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formula:C21H22ClN3OS2Purezza:98.2%Colore e forma:SolidPeso molecolare:432ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purezza:97.32% - 99.36%Colore e forma:SolidPeso molecolare:272.26Ref: TM-T3594
1mg40,00€2mg52,00€5mg85,00€10mg115,00€25mg172,00€50mg274,00€100mg427,00€500mg938,00€1mL*10mM (DMSO)85,00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Formula:C24H21Cl2N3OS3Purezza:99.13%Colore e forma:SolidPeso molecolare:534.53Ref: TM-T5350
1mg62,00€2mg88,00€5mg130,00€10mg188,00€25mg350,00€50mg557,00€100mg782,00€200mg1.035,00€Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Formula:C32H48N4O8Purezza:99.88%Colore e forma:SolidPeso molecolare:616.75Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFormula:C36H56O9Purezza:96.16% - 98.99%Colore e forma:SolidPeso molecolare:632.8217-AEP-GA
CAS:17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.Formula:C34H50N4O8Purezza:97.77% - 99.56%Colore e forma:SolidPeso molecolare:642.78JG-48
CAS:JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.Formula:C20H16F3N3OS2Colore e forma:SolidPeso molecolare:435.49Hsp90-IN-17
CAS:Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.Formula:C21H20N4O7Colore e forma:SolidPeso molecolare:440.41CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Formula:C19H18ClN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:415.9CH5164840
CAS:CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.Formula:C19H23N5O2SColore e forma:SolidPeso molecolare:385.48HSP90-IN-14
CAS:HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.Formula:C14H8Cl2N4O4SColore e forma:SolidPeso molecolare:399.21CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Formula:C32H32N4O5Purezza:98.82% - 99.89%Colore e forma:SolidPeso molecolare:552.62Ref: TM-T14905
1mg37,00€5mg111,00€10mg210,00€25mg437,00€50mg698,00€100mg1.111,00€1mL*10mM (DMSO)137,00€SEW84
CAS:SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.Formula:C19H14F4N4OSColore e forma:SolidPeso molecolare:422.4PU3
CAS:PU3 is an inhibitor of Hsp90.Formula:C19H25N5O3Purezza:98%Colore e forma:SolidPeso molecolare:371.436BrCaQ
CAS:6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.Formula:C18H15BrN2O3Colore e forma:SolidPeso molecolare:387.23Malonganenone A
CAS:Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.Formula:C26H38N4O2Colore e forma:SolidPeso molecolare:438.61Displurigen
CAS:Displurigen is an inhibitor of ATPase activity of HSP70.Formula:C15H10O4SPurezza:98%Colore e forma:SolidPeso molecolare:286.3Icapamespib HCl
CAS:Icapamespib (PU-HZ151) is an HSP90 inhibitor; EC50 of 5 nM, logD of 2.37; targets epichaperomes, effective in cells, mice, and humans.Formula:C19H25Cl2IN6O2SColore e forma:SolidPeso molecolare:599.31CH5015765
CAS:CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.Formula:C16H13ClN4OSColore e forma:SolidPeso molecolare:344.82YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Formula:C27H27N3O4S3Colore e forma:SolidPeso molecolare:553.72Grp94-IN-2
CAS:Grp94-IN-2 is a inhibitor of Grp94.Formula:C22H23ClN2O5Colore e forma:SolidPeso molecolare:430.88BF844
CAS:BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.Formula:C21H19ClN4OColore e forma:SolidPeso molecolare:378.85HSP90-IN-12
CAS:VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.Formula:C25H36O4Colore e forma:SolidPeso molecolare:400.55Hsp90-IN-15
CAS:Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.Formula:C23H27F3N4Colore e forma:SolidPeso molecolare:416.48MPC-3100
CAS:MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].Formula:C22H25BrN6O4SColore e forma:SolidPeso molecolare:549.44Retaspimycin Hydrochloride
CAS:Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).Formula:C31H46ClN3O8Purezza:98%Colore e forma:SolidPeso molecolare:624.17HSP90-IN-22
CAS:HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFormula:C25H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:434.53Retaspimycin
CAS:Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).Formula:C31H45N3O8Purezza:98%Colore e forma:SolidPeso molecolare:587.7KUNB31
CAS:KUNB31 is a potent and selective inhibitor of Hsp90β.Formula:C19H18N2O3Colore e forma:SolidPeso molecolare:322.36HSP90-IN-20
CAS:HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.Formula:C26H32N4O4Colore e forma:SolidPeso molecolare:464.56BIIB028
CAS:BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.Formula:C19H21ClN5O5PColore e forma:SolidPeso molecolare:465.83Heat Shock Protein Inhibitor II
CAS:Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.Formula:C12H11NO3Colore e forma:SolidPeso molecolare:217.22YM-1
CAS:YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.Formula:C20H20ClN3OS2Colore e forma:SolidPeso molecolare:417.98SW02
CAS:SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Formula:C19H23BrN2O5Colore e forma:SolidPeso molecolare:439.3PU24FCl
CAS:PU24FCl is a specific inhibitor of tumor Hsp90.Formula:C20H21ClFN5O3Colore e forma:SolidPeso molecolare:433.86BMS-358233
CAS:BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.Formula:C25H25ClN6O2SColore e forma:SolidPeso molecolare:509.02Vibsanin A
CAS:Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.Formula:C25H38O4Colore e forma:SolidPeso molecolare:402.57Hsp90-Cdc37-IN-1
CAS:Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.Formula:C43H57FN2O6SPurezza:98%Colore e forma:SolidPeso molecolare:748.99AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Formula:C11H18N5O12P3Purezza:98%Colore e forma:SolidPeso molecolare:505.21EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Formula:C21H24ClN5O2Colore e forma:SolidPeso molecolare:413.9Bimoclomol
CAS:Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.Formula:C14H20ClN3O2Colore e forma:SolidPeso molecolare:297.78Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formula:C14H20ClN3O3Purezza:99.15%Colore e forma:SolidPeso molecolare:313.78Ref: TM-T13553
1mg90,00€2mgPrezzo su richiesta5mg59,00€10mg87,00€25mg145,00€50mg208,00€100mg309,00€1mL*10mM (DMSO)69,00€Iroxanadine
CAS:Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation inFormula:C14H20N4OPurezza:98.04% - 99.04%Colore e forma:SolidPeso molecolare:260.33JG-231
CAS:<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Formula:C22H18BrCl2N3OS4Purezza:99.79%Colore e forma:SolidPeso molecolare:619.47SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Formula:C22H26FN3O3Purezza:99.85%Colore e forma:SolidPeso molecolare:399.46Ref: TM-T28824
1mg89,00€5mg188,00€10mg316,00€25mg512,00€50mg702,00€100mg940,00€500mgPrezzo su richiesta1mL*10mM (DMSO)207,00€AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Formula:C11H16N5Na2O12P3Purezza:99.32% - 99.32%Colore e forma:SolidPeso molecolare:549.17HSP90-IN-29
CAS:HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].Formula:C19H20ClN3O4Colore e forma:SolidPeso molecolare:389.83BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formula:C21H24N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:428.51MAO A/HSP90-IN-2
CAS:MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.Formula:C25H31ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:458.98KU-177
CAS:KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Formula:C27H23NO8Purezza:96.92% - 98.54%Colore e forma:SolidPeso molecolare:489.47HSP90-IN-27
CAS:HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Formula:C18H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:343.44Colletofragarone A2
CAS:Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formula:C22H26O6Colore e forma:SolidPeso molecolare:386.44MAO A/HSP90-IN-1
CAS:MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.Formula:C24H29ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:444.95Iroxanadine sulfate
CAS:Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H22N4O5SColore e forma:SolidPeso molecolare:358.41GRP78-IN-2
CAS:GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.Formula:C29H29NO6Colore e forma:SolidPeso molecolare:487.54Flavokawain 1i
CAS:Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.Formula:C21H18O4Colore e forma:SolidPeso molecolare:334.37HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Formula:C29H38O7Purezza:98%Colore e forma:SolidPeso molecolare:498.61HSP70/SIRT2-IN-2
CAS:<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formula:C17H13N3S3Purezza:98%Colore e forma:SolidPeso molecolare:355.5YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Formula:C19H17N3OS2Purezza:98%Colore e forma:SolidPeso molecolare:367.49DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formula:C22H17N3O2SColore e forma:SolidPeso molecolare:387.45HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Colore e forma:SolidPeso molecolare:511.54ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Peso molecolare:431.52KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formula:C20H25NO8Purezza:98%Colore e forma:SolidPeso molecolare:407.41EV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formula:C21H19N3OColore e forma:SolidPeso molecolare:329.40Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formula:C24H30FNO6Colore e forma:SolidPeso molecolare:447.5Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formula:C22H21ClO8Colore e forma:SolidPeso molecolare:448.85Onalespib lactate
CAS:Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Formula:C27H37N3O6Colore e forma:SolidPeso molecolare:499.6HSP90α-IN-1
CAS:HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formula:C19H16N4O2Colore e forma:SolidPeso molecolare:332.356C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formula:C29H28O8Colore e forma:SolidPeso molecolare:504.53HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Colore e forma:SolidPeso molecolare:528.68Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColore e forma:SolidPeso molecolare:416.38Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21BrN4OColore e forma:SolidPeso molecolare:341.25Macbecin I
CAS:Hsp90 inhibitorFormula:C30H42N2O8Purezza:98%Colore e forma:SolidPeso molecolare:558.66Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formula:C23H31N3O4SColore e forma:SolidPeso molecolare:445.58DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formula:C22H23N3O2SColore e forma:SolidPeso molecolare:393.50KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Colore e forma:SolidPeso molecolare:414.85Hsp90-IN-37
CAS:Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formula:C12H15N3O2Colore e forma:SolidPeso molecolare:233.266
