HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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Novobiocin Sodium
CAS:<p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>Formula:C31H35N2NaO11Purezza:99% - 99.28%Colore e forma:SolidPeso molecolare:634.61Ethoxyquin
CAS:<p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>Formula:C14H19NOPurezza:97.15% - 98.73%Colore e forma:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecolare:217.31CC-99677
CAS:<p>CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.</p>Formula:C22H20ClN5O3SPurezza:99.59%Colore e forma:SolidPeso molecolare:469.94Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formula:C18H24ClN3O7Purezza:99.44% - 99.98%Colore e forma:SolidPeso molecolare:429.85GRP78-IN-3
CAS:<p>GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.</p>Formula:C17H18N4O2SPurezza:99.11%Colore e forma:SoildPeso molecolare:342.42IPI-493
CAS:IPI-493 is a bioactive chemical.Formula:C28H39N3O8Purezza:>99.99%Colore e forma:SolidPeso molecolare:545.62Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formula:C46H62N4O11Purezza:98.87% - 99.7%Colore e forma:Red-Violet Crystalline PowderPeso molecolare:847Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Formula:C14H11NO4Purezza:99.03% - 99.96%Colore e forma:SolidPeso molecolare:257.24PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Formula:C43H50N6O7Purezza:98%Colore e forma:SolidPeso molecolare:762.89HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Colore e forma:SolidPeso molecolare:1062.27p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Formula:C44H81N15O11SPurezza:98%Colore e forma:SolidPeso molecolare:1028.27NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormula:C28H32N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:476.63NDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Formula:C31H35F3N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:604.68HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formula:C29H48O10Purezza:98%Colore e forma:SolidPeso molecolare:556.69PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Formula:C32H29ClN8O5Colore e forma:SolidPeso molecolare:641.08Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Colore e forma:SolidPeso molecolare:481.43MPC-0767
CAS:<p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>Formula:C26H36BrN7O9S2Colore e forma:SolidPeso molecolare:734.64dPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Colore e forma:Odour SolidNPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formula:C32H32FN5O4Purezza:99.29%Colore e forma:SolidPeso molecolare:569.63A17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Formula:C76H105N19O20SColore e forma:SolidPeso molecolare:1636.83Neoantimycin
CAS:Neoantimycin: S. orinoci antibiotic, mild antifungal, like antimycin, from different Streptomyces, biosynthesis known, active variants found.Formula:C36H46N2O12Colore e forma:SolidPeso molecolare:698.766HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Formula:C52H60N6O12SPurezza:97.09%Colore e forma:SolidPeso molecolare:993.133-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Formula:C13H11N5O2Purezza:99.88%Colore e forma:SolidPeso molecolare:269.26Arimoclomol citrate
CAS:Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.Formula:C20H28ClN3O10Colore e forma:SolidPeso molecolare:505.916BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Formula:C45H47Br2N2O3PColore e forma:SolidPeso molecolare:854.65Gamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Formula:C52H65N3O8PPurezza:98%Colore e forma:SolidPeso molecolare:891.078DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formula:C13H9BrClN5O2Purezza:99.37%Colore e forma:SolidPeso molecolare:382.6Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Purezza:98%Colore e forma:Odour SolidHsp70-derived octapeptide
CAS:TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.Formula:C36H58N8O16Purezza:98%Colore e forma:SolidPeso molecolare:858.89TRAP1-IN-2
CAS:<p>TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.</p>Formula:C46H42F6N2O5P2Purezza:98%Colore e forma:SolidPeso molecolare:878.77TRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Formula:C45H39F7N2O4P2Purezza:98%Colore e forma:SolidPeso molecolare:866.74Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purezza:98%Colore e forma:SolidPeso molecolare:668.81Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purezza:98%Colore e forma:Off-White To Fawn SolidPeso molecolare:710.87Grp94 Inhibitor-3
<p>Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.</p>Formula:C24H20ClNO4Colore e forma:SolidPeso molecolare:421.8717-DMAP-GA
CAS:17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.Formula:C33H50N4O8Colore e forma:SolidPeso molecolare:630.783Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formula:C41H64N12O12SPurezza:98%Colore e forma:SolidPeso molecolare:949.09JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Formula:C20H22ClN3OS3Colore e forma:SolidPeso molecolare:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Formula:C16H18O5Colore e forma:SolidPeso molecolare:290.315HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purezza:98%Colore e forma:Odour SolidHA15-Biotin
CAS:<p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>Formula:C37H45N7O5S3Colore e forma:SolidPeso molecolare:763.99NMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Formula:C22H22N4O7Purezza:99.84%Colore e forma:SolidPeso molecolare:454.43HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formula:C27H33N5O5Colore e forma:SolidPeso molecolare:507.58Hsp90-IN-36
<p>Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.</p>Formula:C20H13F4N3O4Colore e forma:SolidPeso molecolare:435.328Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Colore e forma:SolidPeso molecolare:730.34008PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Formula:C18H22ClIN6O2SPurezza:98.95%Colore e forma:SoildPeso molecolare:548.83MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Formula:C54H66N4O10Colore e forma:SolidPeso molecolare:931.12HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formula:C22H24N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:444.5PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurezza:98.31% - 99.937%Colore e forma:SolidPeso molecolare:512.37Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurezza:98.98%Colore e forma:SolidPeso molecolare:442.58CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Formula:C27H23N3O4Colore e forma:SolidPeso molecolare:453.49
