HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 176 prodotti per "HSP".
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Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurezza:98.98%Colore e forma:White SolidPeso molecolare:442.58VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Formula:C25H23Cl2N7O4Purezza:97.03% - 99.55%Colore e forma:SolidPeso molecolare:556.4Ref: TM-T7010
2mg44,00€5mg65,00€1mL*10mM (DMSO)80,00€10mg88,00€25mg155,00€50mg268,00€100mg442,00€200mg620,00€DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formula:C25H29N5O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:495.59Ref: TM-T9202
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg119,00€25mg250,00€50mg369,00€100mg525,00€200mg710,00€NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purezza:98.03% - 99.32%Colore e forma:White SolidPeso molecolare:379.39ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purezza:97.32% - 99.36%Colore e forma:Red SolidPeso molecolare:272.26Ref: TM-T3594
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)80,00€10mg109,00€25mg168,00€50mg259,00€100mg405,00€500mg888,00€Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purezza:99.86%Colore e forma:Yellow SolidPeso molecolare:337.37Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formula:C20H20N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:364.4Ref: TM-T2309
5mg63,00€1mL*10mM (DMSO)71,00€10mg93,00€25mg126,00€50mg158,00€100mg236,00€200mg401,00€500mg665,00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Formula:C24H21Cl2N3OS3Purezza:99.13%Colore e forma:Yellow SolidPeso molecolare:534.53Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formula:C24H30O9Purezza:98.82% - 99.22%Colore e forma:SolidPeso molecolare:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formula:C22H28N2O2Purezza:97.02% - 98.83%Colore e forma:White SolidPeso molecolare:352.47HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Formula:C26H30Cl4N4O2Colore e forma:SolidPeso molecolare:572.35KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Formula:C30H42N2O9Purezza:98.68% - 99.52%Colore e forma:SolidPeso molecolare:574.66Ref: TM-T6558
1mg52,00€2mg77,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg177,00€25mg299,00€50mg447,00€100mg627,00€MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Formula:C12H8FN3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:293.27Ref: TM-T8741
500µg46,00€1mg66,00€1mL*10mM (DMSO)136,00€5mg144,00€10mg205,00€25mg349,00€50mg500,00€100mg700,00€200mg954,00€Shepherdin 79-87 acetate
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.Formula:C43H68N12O14SPurezza:98.08%Colore e forma:SolidPeso molecolare:1009.14Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formula:C25H26N8OPurezza:99.22% - 99.49%Colore e forma:White SolidPeso molecolare:454.53Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formula:C23H28O11Purezza:96.9% - 97.43%Colore e forma:White Fine PowderPeso molecolare:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21ClN4OColore e forma:SolidPeso molecolare:296.8Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Formula:C31H43N3O8Purezza:98.24% - 99.83%Colore e forma:Purple SolidPeso molecolare:585.69Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purezza:99.64% - 99.68%Colore e forma:SolidPeso molecolare:482.57Ref: TM-T21883
1mg371,00€5mg1.108,00€1mL*10mM (DMSO)1.215,00€10mg1.513,00€25mg2.242,00€50mg3.025,00€100mg4.078,00€p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).Formula:C46H85N15O13SPurezza:96.33%Colore e forma:White SolidPeso molecolare:1088.32VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formula:C19H18ClN3O4Purezza:99.24% - >99.99%Colore e forma:White SolidPeso molecolare:387.82Ref: TM-T2268
1mg57,00€2mg80,00€1mL*10mM (DMSO)90,00€5mg105,00€10mg164,00€25mg268,00€50mg447,00€100mg610,00€KBU2046
CAS:KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.Formula:C15H11FO2Purezza:99.89%Colore e forma:White SolidPeso molecolare:242.24Ref: TM-T15646
2mg33,00€5mg50,00€1mL*10mM (DMSO)50,00€10mg71,00€25mg133,00€50mg200,00€100mg304,00€200mg425,00€YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purezza:97.25%Colore e forma:White SolidPeso molecolare:398.84Ref: TM-T8901
1mg46,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg250,00€50mg369,00€100mg525,00€200mg710,00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purezza:98.89%Colore e forma:SolidPeso molecolare:409.52Ref: TM-T4125
1mg52,00€2mg94,00€1mL*10mM (DMSO)123,00€5mg132,00€10mg195,00€25mg439,00€50mg642,00€100mg888,00€Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFormula:C28H34O5Purezza:99.52%Colore e forma:White SolidPeso molecolare:450.57Ref: TM-TN6729
1mg124,00€5mg271,00€1mL*10mM (DMSO)334,00€10mg489,00€25mg735,00€50mg1.018,00€100mg1.378,00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Formula:C29H40N2O9Purezza:97.59% - 99.27%Colore e forma:Yellow To Orange PowderPeso molecolare:560.64L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formula:C8H15N3O4Purezza:99.71% - 99.97%Colore e forma:White SolidPeso molecolare:217.22MK2-IN-1
CAS:MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.Formula:C27H25ClN4O2Colore e forma:SolidPeso molecolare:472.97DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purezza:98.86% - 99.29%Colore e forma:SolidPeso molecolare:309.68Ref: TM-T8858
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg200,00€50mg319,00€100mg512,00€500mg1.071,00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Formula:C18H19N5SPurezza:99.13%Colore e forma:SolidPeso molecolare:337.44TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Formula:C25H31N5O4Purezza:98.79%Colore e forma:SolidPeso molecolare:465.54Ref: TM-T3527
1mg34,00€5mg75,00€1mL*10mM (DMSO)77,00€10mg105,00€25mg200,00€50mg281,00€100mg409,00€200mg590,00€TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formula:C25H32ClN5O4Purezza:97.55%Colore e forma:Yellow SolidPeso molecolare:502.01BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurezza:98% - 99.82%Colore e forma:SolidPeso molecolare:318.76MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formula:C21H22ClN3OS2Purezza:98.2%Colore e forma:SolidPeso molecolare:432Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurezza:99.33% - 99.79%Colore e forma:SolidPeso molecolare:181.21XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formula:C29H37N5O3Purezza:99.18%Colore e forma:SolidPeso molecolare:503.64HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Formula:C24H28N6O2SPurezza:99.91%Colore e forma:White SolidPeso molecolare:464.58Ref: TM-T3487
1mg90,00€5mg215,00€1mL*10mM (DMSO)219,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purezza:97.32%Colore e forma:SolidPeso molecolare:509.43KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purezza:98.90%Colore e forma:SolidPeso molecolare:245.23Ref: TM-T2444
2mg38,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg77,00€25mg149,00€50mg220,00€100mg331,00€200mg530,00€Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formula:C16H32O2Purezza:99.17% - 99.67%Colore e forma:White SolidPeso molecolare:256.42HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormula:C13H12O4SPurezza:99.51%Colore e forma:SolidPeso molecolare:264.3Ref: TM-T7265
1mg123,00€2mg175,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg713,00€50mg1.009,00€100mg1.341,00€VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurezza:97.31% - 99.85%Colore e forma:SolidPeso molecolare:480.41KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formula:C13H12N6O2Purezza:97.25% - 99.91%Colore e forma:SolidPeso molecolare:284.27Ref: TM-T3652
5mg49,00€1mL*10mM (DMSO)50,00€10mg73,00€25mg150,00€50mg249,00€100mg484,00€200mg680,00€500mg1.035,00€VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purezza:99.36% - 99.99%Colore e forma:SolidPeso molecolare:387.82Ref: TM-T3454
2mg43,00€1mL*10mM (DMSO)50,00€5mg60,00€10mg96,00€25mg156,00€50mg245,00€100mg335,00€200mg475,00€HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Formula:C26H27ClN4O2Purezza:97.15%Colore e forma:SolidPeso molecolare:462.972-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purezza:98%Colore e forma:SolidPeso molecolare:182.26Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Formula:C26H31N3O5Purezza:98% - 99.25%Colore e forma:SolidPeso molecolare:465.54Ref: TM-T1989
5mg54,00€1mL*10mM (DMSO)59,00€10mg77,00€25mg138,00€50mg210,00€100mg344,00€200mg512,00€500mg825,00€Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formula:C24H31N3O3Purezza:99.01% - 99.66%Colore e forma:SolidPeso molecolare:409.52HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purezza:99.77% - 99.86%Colore e forma:SolidPeso molecolare:466.58Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purezza:95.32% - 99.67%Colore e forma:SolidPeso molecolare:505.56Ref: TM-TQ0131
500µg155,00€1mg187,00€5mg410,00€1mL*10mM (DMSO)449,00€10mg710,00€25mg1.381,00€50mg2.352,00€
